Ciita
Gene Detail

Symbol Name ID

Ciita class II transactivator MGI:108445

Synonyms

C2ta, Gm9475

Feature Type

protein coding gene

Genetic Map

Chromosome 16

5.65 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr16:10488178-10527564 bp, + strand From Ensembl annotation of GRCm38   39387 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:207  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Ciita

Human homologs

Human Homolog		CIITA, class II, major histocompatibility complex, transactivator
NCBI Gene ID		4261
neXtProt AC		NX_P33076
Human Synonyms		C2TA, CIITAIV, MHC2TA, NLRA
Human Chr (Location)		16p13; chr16:10971055-11018840 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human CIITA

Alleles and phenotypes

All alleles(9) : Targeted(9)
 

Homozygous targeted mutants are immunologically abnormal with extremely little MHC class II expression, greatly reduced serum IgG, and impaired T-dependent antigen responses.

 
Human Diseases Modeled Using Mouse Ciita (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	negative regulation of transcription, DNA-dependent, negative regulation of transcription from RNA polymerase II promoter, ...
Component	cell surface, nucleus, ...
Function	activating transcription factor binding, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (161)    Tissues (138)    Images (15)
Theiler Stages: 19, 22, 23, 28

Assay Type	Results
RNA in situ	161

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) Genomic(2) cDNA(17) Primer pair(1) Other(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000022504 (Evidence)
Entrez Gene	12265 (Evidence)
DFCI	TC1582497, TC1592539
DoTS	DT.101259489, DT.101355004, DT.110712261, DT.110712262, DT.110712288, DT.87047441, DT.91323989, DT.91339813, DT.91400173
NIA Mouse Gene Index	U016793
Consensus CDS Project	CCDS27950.1
International Mouse Knockout Project Status	Ciita

Sequences

Length	Strain/Species
genomic	ENSMUSG00000022504	Ensembl Gene Model | MGI Sequence Detail	39387	C57BL/6J
transcript	ENSMUST00000023147	Ensembl | MGI Sequence Detail	5254	Not Applicable
polypeptide	ENSMUSP00000023147	Ensembl | MGI Sequence Detail	1078	Not Applicable

All sequences(50) RefSeq(7) UniProt(10)

Polymorphisms

SNPs(215 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR025875	Leucine rich repeat 4
InterPro	IPR008095	MHC class II transactivator
InterPro	IPR007111	NACHT nucleoside triphosphatase
Protein Ontology	PR:000001823	MHC class II transactivator

References

(Earliest) J:65917 Elliott EA, et al., The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules. J Exp Med. 1994 Feb 1;179(2):681-94
(Latest) J:192819 Pihlgren M, et al., TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell-independent isotype switch in mice. Blood. 2013 Jan 3;121(1):85-94
All references(107)

Other accession IDs

MGD-MRK-37489, MGI:3712178