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Ciita
Gene Detail
 Symbol
Name
ID
Ciita
class II transactivator
MGI:108445
Synonyms C2ta, Gm9475
Feature Type protein coding gene
Genetic Map
Chromosome 16
5.65 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr16:10488178-10527564 bp, + strand
From Ensembl annotation of GRCm38

  39387 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:207  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ciita

Human
homologs
Human Homolog CIITA, class II, major histocompatibility complex, transactivator
NCBI Gene ID 4261
neXtProt AC  NX_P33076
Human Synonyms  C2TA, CIITAIV, MHC2TA, NLRA
Human Chr (Location)  16p13; chr16:10866228-10936274 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human CIITA
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous targeted mutants are immunologically abnormal with extremely little MHC class II expression, greatly reduced serum IgG, and impaired T-dependent antigen responses.
 
Human Diseases Modeled Using Mouse Ciita (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Ciita interacts with 215 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (83 annotations)
Process negative regulation of transcription, DNA-templated, negative regulation of transcription from RNA polymerase II promoter, ...
Component cell surface, nucleus, ...
Function 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity, 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (161)    Tissues (138)    Images (15)
Theiler Stages: 19, 22, 23, 28
Assay TypeResults
RNA in situ 161
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(2) cDNA(17) Primer pair(1) Other(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000022504 (Evidence)
Entrez Gene12265 (Evidence)
DFCITC1582497, TC1592539
DoTSDT.101259489, DT.101355004, DT.110712261, DT.110712262, DT.110712288, DT.87047441, DT.91323989, DT.91339813, DT.91400173
NIA Mouse Gene IndexU016793
EC2.3.1.-, 2.7.11.1
Consensus CDS ProjectCCDS27950.1
International Mouse Knockout Project StatusCiita
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022504 Ensembl Gene Model | MGI Sequence Detail 39387 C57BL/6J ±  kb
transcript ENSMUST00000023147 Ensembl | MGI Sequence Detail 5254 Not Applicable 
polypeptide ENSMUSP00000023147 Ensembl | MGI Sequence Detail 1078 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(19) UniProt(10)
Polymorphisms SNPs within 2kb(280 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025875 Leucine rich repeat 4
InterPro IPR008095 MHC class II transactivator
InterPro IPR007111 NACHT nucleoside triphosphatase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000001823 MHC class II transactivator
References (Earliest) J:65917 Elliott EA, et al., The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules. J Exp Med. 1994 Feb 1;179(2):681-94
(Latest) J:208149 Ling W, et al., Mesenchymal stem cells use IDO to regulate immunity in tumor microenvironment. Cancer Res. 2014 Mar 1;74(5):1576-87
All references(114)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-37489, MGI:3712178

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory