About   Help   FAQ
Nfe2l2
Gene Detail
 Symbol
Name
ID
Nfe2l2
nuclear factor, erythroid derived 2, like 2
MGI:108420
Synonyms Nrf2
Feature Type protein coding gene
Genetic Map
Chromosome 2
44.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:75675513-75704641 bp, - strand
From VEGA annotation of GRCm38

  29129 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2412  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Nfe2l2

Human
homologs
Human Homolog NFE2L2, nuclear factor, erythroid 2-like 2
NCBI Gene ID 4780
neXtProt AC  NX_Q16236
Human Synonyms  NRF2
Human Chr (Location)  2q31; chr2:177230303-177265131 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(134) : Gene trapped(122) Targeted(12)
Genomic Mutations involving Nfe2l2 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased sensitivity to oxidative stress in a variety of organs and cells including brain, liver, erythrocytes, and spleen, abnormal tooth enamel, and abnormal response to various injuries, chemical treatments, and induced inflammatory diseases.
 
Phenotype Images(1)
Interactions
Nfe2l2 interacts with 164 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process cellular response to hydrogen peroxide, cellular response to laminar fluid shear stress, ...
Component centrosome, chromatin, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (277)    Tissues (218)    Images (43)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 21, 22, 23, 25, 26, 27, 28
Assay TypeResults
RNA in situ 256
Northern blot 6
RT-PCR 15
cDNA source data(134)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(140) Genomic(2) cDNA(135) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000013248 (Evidence)
Ensembl Gene ModelENSMUSG00000015839 (Evidence)
Entrez Gene18024 (Evidence)
UniGene1025
DFCITC1574760, TC1599000
DoTSDT.494092, DT.55227324
NIA Mouse Gene IndexU022765
PDB1X2R, 2DYH, 3WN7
Consensus CDS ProjectCCDS16150.1
International Mouse Knockout Project StatusNfe2l2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013248 VEGA Gene Model | MGI Sequence Detail 29129 C57BL/6J ±  kb
transcript OTTMUST00000032007 VEGA | MGI Sequence Detail 2475 Not Applicable 
polypeptide OTTMUSP00000014243 VEGA | MGI Sequence Detail 597 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(229 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR004826 Basic leucine zipper domain, Maf-type
InterPro IPR008917 Eukaryotic transcription factor, Skn-1-like, DNA-binding
Protein Ontology PR:000011170 nuclear factor erythroid 2-related factor 2
References (Earliest) J:24214 Chui DH, et al., cDNA cloning of murine Nrf 2 gene, coding for a p45 NF-E2 related transcription factor. Biochem Biophys Res Commun. 1995 Apr 6;209(1):40-6
(Latest) J:210804 Haldar M, et al., Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages. Cell. 2014 Mar 13;156(6):1223-34
All references(318)
Other
accession IDs
MGD-MRK-37463, MGI:2138857

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/23/2014
MGI 5.19
The Jackson Laboratory