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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nfe2l2
nuclear factor, erythroid derived 2, like 2
MGI:108420
41 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ahrtm1Yfk/Ahrtm1Yfk
Nfe2l2tm1Mym/Nfe2l2tm1Mym
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J * ICR 		abnormal xenobiotic pharmacokinetics J:82937
decreased survivor rate J:82937
hepatic steatosis J:82937
postnatal lethality, incomplete penetrance J:82937
Apoetm1Unc/Apoetm1Unc
Nfe2l2tm1Mym/Nfe2l2tm1Mym
involves: 129P2/OlaHsd * C57BL/6J 		abnormal aorta morphology J:143903
abnormal macrophage physiology J:143903
decreased susceptibility to atherosclerosis J:143903
increased circulating glucose level J:143903
increased circulating triglyceride level J:143903
oxidative stress J:143903
Keap1tm1Mym/Keap1tm1Mym
Nfe2l2tm1Mym/Nfe2l2tm1Mym
Not Specified 		normal digestive/alimentary phenotype J:86392
normal integument phenotype J:86392
Lepob/Lepob
Nfe2l2tm1.1Jgpi/Nfe2l2tm1.1Jgpi
Tg(Fabp4-cre)1Rev/0
involves: C57BL/6 		abnormal white fat cell morphology J:208590
decreased white adipose tissue amount J:208590
normal homeostasis/metabolism phenotype J:208590
increased circulating glucose level J:208590
increased circulating triglyceride level J:208590
insulin resistance J:208590
Lepob/Lepob
Nfe2l2tm1Mym/Nfe2l2tm1Mym
B6.Cg-Nfe2l2tm1Mym Lepob 		abnormal adipose tissue development J:208590
abnormal urine color J:208590
abnormal white fat cell morphology J:208590
decreased body weight J:208590
decreased food intake J:208590
decreased liver triglyceride level J:208590
decreased susceptibility to weight gain J:208590
decreased white adipose tissue amount J:208590
hepatic steatosis J:208590
normal homeostasis/metabolism phenotype J:208590
hyperglycemia J:208590
increased circulating triglyceride level J:208590
insulin resistance J:208590
premature death J:208590
Nfe2tm1Sho/Nfe2tm1Sho
Nfe2l2tm1Ney/Nfe2l2tm1Ney
involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 		anemia J:47440
thrombocytopenia J:47440
Nfe2l1tm1Ywk/Nfe2l1tm1Ywk
Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
involves: 129X1/SvJ 		decreased embryo size J:86725
embryonic growth retardation J:86725
embryonic lethality during organogenesis, complete penetrance J:86725
increased apoptosis J:86725
increased cellular sensitivity to oxidative stress J:86725
increased fibroblast apoptosis J:86725
oxidative stress J:86725
Nfe2l2tm1Mym/Nfe2l2tm1Mym
n-TUtca2tm2Mym/n-TUtca2tm2.1Mym
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		increased apoptosis J:130723
increased cellular sensitivity to hydrogen peroxide J:130723
increased cellular sensitivity to oxidative stress J:130723
Nfe2l2tm1Mym/Nfe2l2tm1Mym
Tg(Alb1-cre)1Dlr/0
n-TUtca2tm2Mym/n-TUtca2tm2.1Mym
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N 		abnormal hepatocyte morphology J:130723
increased circulating alanine transaminase level J:130723
increased hepatocyte apoptosis J:130723
lethality at weaning, incomplete penetrance J:130723
liver degeneration J:130723
pale liver J:130723
premature death J:130723
Nfe2l2tm1Ney/Nfe2l2tm1Ney
Nfe2l3tm1Vbl/Nfe2l3tm1Vbl
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J 		no abnormal phenotype detected J:89893
Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
Slc3a1tm1Jat/Slc3a1tm1Jat
involves: 129 * 129X1/SvJ * C57BL/6 		cystolithiasis J:254803
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory