Keap1^tm1Mym
Targeted Allele Detail

Summary

• Symbol: Keap1^tm1Mym
• Name: kelch-like ECH-associated protein 1; targeted mutation 1, Masayuki Yamamoto
• MGI ID: MGI:2681416
• Synonyms: Keap1^-
• Gene: Keap1 Location: Chr9:21141026-21150628 bp, - strand Genetic Position: Chr9, 7.74 cM, cytoband A3
• Alliance: Keap1^tm1Mym page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86392
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Hypomorph, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encoding 8 through 204 was replaced with a cassette containing nls-lacZ and neo. Transcript was undetected by Northern blot analysis of homozygous mutant mouse embryonic fibroblasts. Product from the inserted lacZ sequence was detected by Western blot. The allele is hypomorphic (J:182931). (J:86392)

Expression

In Mice Carrying this Mutation:	4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Keap1 Mutation: 34 strains or lines available

References

• Original: J:86392 Wakabayashi N, et al., Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat Genet. 2003 Nov;35(3):238-45
• All: 40 reference(s)