Phenotypes associated with this allele

• Allele Symbol: Keap1^tm1Mym
• Allele Name: targeted mutation 1, Masayuki Yamamoto
• Allele ID: MGI:2681416
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Keap1^tm1Mym/Keap1^tm1Mym	involves: 129P2/OlaHsd * C57BL/6J	MGI:2681441
cn2	Keap1^tm1Mym/Keap1^tm2Mym Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129P2/OlaHsd * C57BL/6 * DBA	MGI:3620636
cx3	Keap1^tm1Mym/Keap1^tm1Mym Nfe2l2^tm1Mym/Nfe2l2^tm1Mym	Not Specified	MGI:2681444

Genotype
MGI:2681441

hm1

• Allelic Composition: Keap1^tm1Mym/Keap1^tm1Mym
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:86392 )

• none survived past 21 days of age

• death putatively due to gastric obstruction and excessive hyperkeratosis

digestive/alimentary system

abnormal esophageal epithelium morphology ( J:86392 )

• multiple cornified layers of the inner wall

abnormal stomach glandular epithelium morphology ( J:86392 )

• while relatively intact, inflammation and detachment was observed at advanced stages

abnormal stomach non-glandular epithelium morphology ( J:86392 )

• ulceration and infiltration of inflammatory cells in the detached area of the mucosa

increased stomach mucosa thickness ( J:86392 )

• thickened cornified layer evident around 9 days of age

• at more advanced stages, the thickened layer detached and formed a multilayered keratinous mass in the gastric lumen

small stomach ( J:86392 )

growth/size/body

decreased body size ( J:86392 )

decreased body weight ( J:86392 )

postnatal growth retardation ( J:86392 )

• severe growth retardation beginning around 4 days of age, in spite of normal suckling ability

integument

hyperkeratosis ( J:86392 )

scaly skin ( J:86392 )

Genotype
MGI:3620636

cn2

• Allelic Composition: Keap1^tm1Mym/Keap1^tm2Mym; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:103791 )

• unlike most wild-type mice, mutant mice survive following intraperitoneal administration of 600-mg or 700-mg acetaminophen/kg body weight

homeostasis/metabolism

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:103791 )

• unlike most wild-type mice, mutant mice survive following intraperitoneal administration of 600-mg or 700-mg acetaminophen/kg body weight

decreased physiological sensitivity to xenobiotic ( J:103791 )

• much milder hepatic injury in livers of mutant mice following acetaminophen exposure

Genotype
MGI:2681444

cx3

• Allelic Composition: Keap1^tm1Mym/Keap1^tm1Mym; Nfe2l2^tm1Mym/Nfe2l2^tm1Mym
• Genetic Background: Not Specified

digestive/alimentary system

digestive/alimentary phenotype ( J:86392 )

N • no observed hyperkeratotic phenotype of the esophagi and mice lived beyond 3 weeks of age

integument

integument phenotype ( J:86392 )

N • scaly skin was not observed