Clk1 MGI Mouse Gene Detail - MGI:107403

Symbol

Clk1
Name

CDC-like kinase 1
Synonyms

Clk1, STY

Feature Type

protein coding gene
IDs

MGI:107403
NCBI Gene: 12747
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:58451147-58463247 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 29.09 cM
Mapping Data

2 experiments

SNPs within 2kb

359 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107403	protein coding gene	Chr1:58449348-58463247 (-)
129S1/SvImJ	ENSMUSG00200018344	protein coding gene	Chr1:55952407-55964597 (-)
A/J	ENSMUSG00195026899	protein coding gene	Chr1:55485699-55497898 (-)
AKR/J	ENSMUSG00220035550	protein coding gene	Chr1:55575871-55588066 (-)
BALB/cJ	ENSMUSG00180013635	protein coding gene	Chr1:55733259-55745456 (-)
C3H/HeJ	ENSMUSG00175001002	protein coding gene	Chr1:55863208-55875403 (-)
C57BL/6NJ	ENSMUSG00215018090	protein coding gene	Chr1:55794981-55807176 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014163	protein coding gene	Chr1:52165588-52180246 (-)
CAST/EiJ	ENSTCUG00005012933	protein coding gene	Chr1:55639960-55652131 (-)
CBA/J	ENSMUSG00210033698	protein coding gene	Chr1:55543642-55555829 (-)
DBA/2J	ENSMUSG00185054691	protein coding gene	Chr1:56663347-56675534 (-)
FVB/NJ	ENSMUSG00205011999	protein coding gene	Chr1:55509036-55521232 (-)
JF1/MsJ	ENSUMUG00000028406	protein coding gene	Chr1:55630674-55643772 (-)
LP/J	ENSMUSG00230025195	protein coding gene	Chr1:56672965-56685154 (-)
NOD/ShiLtJ	ENSMUSG00190029531	protein coding gene	Chr1:55714653-55726840 (-)
NZO/HlLtJ	ENSMUSG00225008318	protein coding gene	Chr1:59871263-59883682 (-)
PWK/PhJ	ENSLUMG00010023445	protein coding gene	Chr1:55164908-55177797 (-)
SPRET/EiJ	ENSMSPG00010022300	protein coding gene	Chr1:57023669-57034569 (-)
WSB/EiJ	ENSIUOG00005018878	protein coding gene	Chr1:55339447-55351643 (-)

Human Ortholog

CLK1, CDC like kinase 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CLK1, CDC like kinase 1
Synonyms

CLK, CLK/STY, STY
Links

HGNC:2068

NCBI Gene ID: 1195

UniProt: P49759
Chr Location

2q33.1; chr2:200853009-200864697 (-) GRCh38

MGI Vertebrate Homology

Clk1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CLK1
Gene Tree

Clk1

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

23
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Clk1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

30
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

622
Tissues

19
cDNA Data

14
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase clk1

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All Sequences

58
RefSeq

4
UniProt

2
CCDS

CCDS35577.1, CCDS35578.1

Ensembl

ENSMUSG00000026034 (Evidence)
NCBI Gene

12747

			Length	Strain/Species	Flank
genomic	12747	NCBI Gene Model \| MGI Sequence Detail	12101	C57BL/6J	± kb
transcript	NR_027854	RefSeq \| MGI Sequence Detail	3088	ZRU/MplStud
polypeptide	P22518	UniProt \| EBI \| MGI Sequence Detail	483	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005584 dual specificity protein kinase CLK1

(term hierarchy)
EC

2.7.12.1
InterPro Domains

IPR051175 Dual specificity CLK kinases

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

P22518 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 20

cDNA 16

Primer pair 1

Other 3

Microarray probesets 3

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MGD-MRK-35871

Summaries

All 63

Developmental Gene Expression 5

Gene Ontology 13

Phenotypes 20
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:388027 Wang W, et al., CCDC174 deficiency impaired human fertility by affecting the alternative splicing of maternal mRNAs. EMBO Mol Med. 2026 Jun;18(6):2436-2454

TSS for Clk1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11780	Chr1:58463201-58463223 (-)	35 bp
Tssr11779	Chr1:58463166-58463187 (-)	70 bp
Tssr11778	Chr1:58462003-58462008 (-)	1,241 bp
Tssr11777	Chr1:58459474-58459490 (-)	3,765 bp
Tssr11776	Chr1:58459154-58459165 (-)	4,087 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24