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Clk1
Gene Detail
Symbol

Name
ID
Clk1
CDC-like kinase 1
MGI:107403
Synonyms
Clk1, STY
Feature Type
protein coding gene
Genetic Map
Chromosome 1
29.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:58410189-58424066 bp, - strand
From VEGA annotation of GRCm38

  13878 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:101535  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: CLK1
Protein SuperFamily: dual specificity protein kinase CLK
Gene Tree: Clk1

Human
homologs
CLK1, CDC-like kinase 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1195
neXtProt AC: NX_P49759

Human Synonyms: CLK, CLK/STY, STY

Human Chr (Location): 2q33; chr2:200853009-200864744 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(25) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Clk1 interacts with 68 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, ...
Component cytoplasm, nucleus
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (19)    Tissues (16)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 13
Northern blot 6
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase clk1    NEW 
Molecular
reagents
All nucleic(15) cDNA(14) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021803 (Evidence)
Ensembl Gene Model ENSMUSG00000026034 (Evidence)
Entrez Gene 12747 (Evidence)
DFCI TC1572432, TC1586932, TC1594151, TC1601608, TC1734530
NIA Mouse Gene Index U021353
EC 2.7.12.1
Consensus CDS Project CCDS35577.1, CCDS35578.1
International Mouse Phenotyping Consortium Status Clk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021803 VEGA Gene Model | MGI Sequence Detail 13878 C57BL/6J ±  kb
transcript OTTMUST00000051743 VEGA | MGI Sequence Detail 1796 Not Applicable 
polypeptide OTTMUSP00000024414 VEGA | MGI Sequence Detail 483 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(5) UniProt(2)
Polymorphisms
SNPs within 2kb(74 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005584 dual specificity protein kinase CLK1
References
(Earliest) J:31535 Merton H, VII. Studies on Reproduction in the Albino mouse. I. The period of gestation and the time of parturition. Proc R Soc Edinb [Biol]. 1938;58:80-96
(Latest) J:215230 Aubol BE, et al., N-terminus of the protein kinase CLK1 induces SR protein hyperphosphorylation. Biochem J. 2014 Aug 15;462(1):143-52
All references(41)
Other
accession IDs
MGD-MRK-35871

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory