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Pctp
Gene Detail
 Symbol
Name
ID
Pctp
phosphatidylcholine transfer protein
MGI:107375
Synonyms PC-TP, StarD2
Feature Type protein coding gene
Genetic Map
Chromosome 11
54.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:89982665-90002894 bp, - strand
From VEGA annotation of GRCm38

  20230 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32054  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Pctp

Human
homologs
Human Homolog PCTP, phosphatidylcholine transfer protein
NCBI Gene ID 58488
neXtProt AC  NX_Q9UKL6
Human Synonyms  PC-TP, STARD2
Human Chr (Location)  17q21-q24; chr17:55750979-55843156 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Spontaneous(1) Targeted(5)
Genomic Mutations involving Pctp (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display impaired biliary lipid secretion in response to a lithogenic diet, and show altered adaptive responses of macrophages to cholesterol loading. Mice heterozygous for a spontaneous allele show lack of phosphatidylcholine transfer protein activity.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Pctp interacts with 222 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cholesterol metabolic process, lipid transport, ...
Component cytoplasm
Function lipid binding, phosphatidylcholine binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (38)    Tissues (32)   
Theiler Stages: 16, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNase protection 38
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(20) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000001285 (Evidence)
Ensembl Gene ModelENSMUSG00000020553 (Evidence)
Entrez Gene18559 (Evidence)
UniGene5062
DFCITC1583646, TC1598565, TC1652512
DoTSDT.101312202, DT.110530892, DT.60118093, DT.97398745
NIA Mouse Gene IndexU033260
Consensus CDS ProjectCCDS25238.1
International Mouse Knockout Project StatusPctp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001285 VEGA Gene Model | MGI Sequence Detail 20230 C57BL/6J ±  kb
transcript OTTMUST00000002557 VEGA | MGI Sequence Detail 2723 Not Applicable 
polypeptide OTTMUSP00000001265 VEGA | MGI Sequence Detail 214 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(308 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002913 START domain
InterPro IPR023393 START-like domain
Protein Ontology PR:000012444 phosphatidylcholine transfer protein
References (Earliest) J:33157 Geijtenbeek TB, et al., cDNA cloning and tissue-specific expression of the phosphatidylcholine transfer protein gene. Biochem J. 1996 May 15;316(Pt 1):49-55
(Latest) J:175528 Berndt A, et al., Identification of fat4 and tsc22d1 as novel candidate genes for spontaneous pulmonary adenomas. Cancer Res. 2011 Sep 1;71(17):5779-91
All references(43)
Other
accession IDs
MGD-MRK-35842

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory