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Ccr2
Gene Detail
Symbol

Name
ID
Ccr2
chemokine (C-C motif) receptor 2
MGI:106185
Synonyms
CC-CKR-2, CCR2A, CCR2B, CKR2, CKR2A, CKR2B, Cmkbr2
Feature Type
protein coding gene
Genetic Map
Chromosome 9
75.05 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr9:124101950-124113557 bp, + strand
From VEGA annotation of GRCm38

  11608 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:537  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 3 zebrafish

HCOP human homology predictions: CCR2
Protein SuperFamily: chemokine receptor
Gene Tree: Ccr2

Human
homologs
CCR2, chemokine (C-C motif) receptor 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 729230
neXtProt AC: NX_P41597

Human Synonyms: CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R

Human Chr (Location): 3p21.31; chr3:46353744-46360940 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit defects in leukocyte physiology that result in altered response to myocardial infarction and increased susceptibility to bacterial infection and colitis. Mice may also exhibit retinal degeneration and alcohol aversion depending on the knock-out allele.
 
Human Diseases Modeled in Mice Using Ccr2 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(1)
Interactions
Ccr2 interacts with 260 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (51)    Tissues (50)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 46
RNase protection 5
cDNA source data(29)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CCR2    NEW 
Molecular
reagents
All nucleic(35) Genomic(2) cDNA(30) Primer pair(1) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000035281 (Evidence)
Ensembl Gene Model ENSMUSG00000049103 (Evidence)
Entrez Gene 12772 (Evidence)
UniGene 6272
DFCI TC1722440, TC1583964
DoTS DT.530336
NIA Mouse Gene Index U011204
Consensus CDS Project CCDS23669.1
International Mouse Phenotyping Consortium Status Ccr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035281 VEGA Gene Model | MGI Sequence Detail 11608 C57BL/6J ±  kb
transcript OTTMUST00000089981 VEGA | MGI Sequence Detail 2265 Not Applicable 
polypeptide OTTMUSP00000049243 VEGA | MGI Sequence Detail 373 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(10) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(228 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002237 CC chemokine receptor 2
InterPro IPR000355 Chemokine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001199 C-C chemokine receptor type 2
References
(Earliest) J:28836 Kozak CA, et al., Mapping of the mouse macrophage inflammatory protein-1 alpha receptor gene Scya3r and two related mouse beta chemokine receptor-like genes to chromosome 9. Genomics. 1995 Sep 1;29(1):294-6
(Latest) J:220361 Evrard M, et al., Visualization of bone marrow monocyte mobilization using Cx3cr1gfp/+Flt3L-/- reporter mouse by multiphoton intravital microscopy. J Leukoc Biol. 2015 Mar;97(3):611-9
All references(372)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-33876

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory