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Ccr2
Gene Detail
 Symbol
Name
ID
Ccr2
chemokine (C-C motif) receptor 2
MGI:106185
Synonyms CC-CKR-2, CCR2A, CCR2B, CKR2, CKR2A, CKR2B, Cmkbr2
Feature Type protein coding gene
Genetic Map
Chromosome 9
75.05 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr9:124101950-124113557 bp, + strand
From VEGA annotation of GRCm38

  11608 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:537  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 3 zebrafish

Protein SuperFamily: chemokine receptor
Gene Tree: Ccr2

Human
homologs
Human Homolog CCR2, chemokine (C-C motif) receptor 2
NCBI Gene ID 729230
neXtProt AC  NX_P41597
Human Synonyms  CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R
Human Chr (Location)  3p21.31; chr3:46353744-46360922 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit defects in leukocyte physiology that result in altered response to myocardial infarction and increased susceptibility to bacterial infection and colitis. Mice may also exhibit retinal degeneration and alcohol aversion depending on the knock-out allele.
 
Human Diseases Modeled Using Mouse Ccr2 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)
Interactions
Ccr2 interacts with 260 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (57 annotations)
Process angiogenesis, apoptotic cell clearance, ...
Component external side of plasma membrane, integral component of membrane, ...
Function C-C chemokine receptor activity, chemokine (C-C motif) ligand 12 binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (51)    Tissues (50)    Images (2)
Theiler Stages: 13, 20, 23, 28
Assay TypeResults
RT-PCR 46
RNase protection 5
cDNA source data(29)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) Genomic(2) cDNA(30) Primer pair(1) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000035281 (Evidence)
Ensembl Gene ModelENSMUSG00000049103 (Evidence)
Entrez Gene12772 (Evidence)
UniGene6272
DFCITC1583964, TC1722440
DoTSDT.530336
NIA Mouse Gene IndexU011204
Consensus CDS ProjectCCDS23669.1
International Mouse Knockout Project StatusCcr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035281 VEGA Gene Model | MGI Sequence Detail 11608 C57BL/6J ±  kb
transcript OTTMUST00000089981 VEGA | MGI Sequence Detail 2265 Not Applicable 
polypeptide OTTMUSP00000049243 VEGA | MGI Sequence Detail 373 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(8) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(228 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002237 CC chemokine receptor 2
InterPro IPR000355 Chemokine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001199 C-C chemokine receptor type 2
References (Earliest) J:28836 Kozak CA, et al., Mapping of the mouse macrophage inflammatory protein-1 alpha receptor gene Scya3r and two related mouse beta chemokine receptor-like genes to chromosome 9. Genomics. 1995 Sep 1;29(1):294-6
(Latest) J:212544 Franklin RA, et al., The cellular and molecular origin of tumor-associated macrophages. Science. 2014 May 23;344(6186):921-5
All references(352)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-33876

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory