102 phenotypes from 9 alleles in 16 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ccr2em1(IMPC)H/Ccr2em1(IMPC)H C57BL/6N-Ccr2em1(IMPC)H/H	abnormal gait	J:211773
	abnormal heart left ventricle morphology	J:211773
	decreased lymphocyte cell number	J:211773
	decreased monocyte cell number	J:211773
	decreased neutrophil cell number	J:211773
	enlarged heart	J:211773
	increased cardiac muscle contractility	J:211773
	increased eosinophil cell number	J:211773
Ccr2tm1.1(CCR2)Rodb/Ccr2tm1.1(CCR2)Rodb involves: C57BL/6	abnormal glucose homeostasis	J:203000
	abnormal macrophage morphology	J:203000
	abnormal podocyte morphology	J:203000
	abnormal renal glomerulus morphology	J:203000
	abnormal urine protein level	J:203000
	normal immune system phenotype	J:203000
	increased physiological sensitivity to xenobiotic	J:203000
Ccr2tm1.1Dnc/Ccr2tm1.1Dnc Not Specified	abnormal dendritic cell chemotaxis	J:223508
	decreased CD11b-high dendritic cell number	J:223508
	increased CD11b-high dendritic cell number	J:223508
	increased dendritic cell number	J:223508
Ccr2tm1.1Mpa/Ccr2tm1.1Mpa involves: BALB/cJ * C57BL/6	abnormal wound healing	J:189044
	decreased macrophage cell number	J:189044
	decreased monocyte cell number	J:189044
Ccr2tm1Blck/Ccr2tm1Blck B6.129P2-Ccr2tm1Blck	abnormal cellular extravasation	J:104744
	abnormal leukocyte adhesion	J:104744
	abnormal response to cardiac infarction	J:104744
Ccr2tm1Brv/Ccr2tm1Brv involves: 129S1/Sv * ICR	abnormal spleen morphology	J:111517
	enlarged liver	J:111517
	enlarged spleen	J:111517
	impaired macrophage chemotaxis	J:111517
	increased eosinophil cell number	J:111517
	increased susceptibility to bacterial infection	J:111517
	liver inflammation	J:111517
	multifocal hepatic necrosis	J:111517
Ccr2tm1Ifc/Ccr2+ involves: 129S4/SvJae * C57BL/6	impaired macrophage chemotaxis	J:121703
Ccr2tm1Ifc/Ccr2tm1Ifc B6.129S4-Ccr2tm1Ifc	decreased susceptibility to induced colitis	J:161138
	normal immune system phenotype	J:154558
	impaired leukocyte tethering or rolling	J:154558
Ccr2tm1Ifc/Ccr2tm1Ifc B6.129S4-Ccr2tm1Ifc/J	abnormal bone mineral density	J:149360
	abnormal bone trabecula morphology	J:149360
	abnormal leukocyte migration	J:106738
	abnormal leukocyte physiology	J:122119
	abnormal microglial cell physiology	J:106738
	abnormal osteoclast cell number	J:149360
	abnormal osteoclast differentiation	J:149360
	abnormal osteoclast physiology	J:149360
	abnormal trabecular bone morphology	J:149360
	decreased acute inflammation	J:106738
	decreased interferon-gamma secretion	J:106738
	decreased osteoclast cell number	J:149360
	decreased susceptibility to bone fracture	J:149360
	decreased tumor growth/size	J:122119
	increased susceptibility to Coronaviridae infection	J:106738
	increased susceptibility to Coronaviridae infection induced morbidity/mortality	J:106738
	increased trabecular bone thickness	J:149360
	increased trabecular bone volume	J:149360
Ccr2tm1Ifc/Ccr2tm1Ifc involves: 129S4/SvJae	abnormal monocyte morphology	J:121281
Ccr2tm1Ifc/Ccr2tm1Ifc involves: 129S4/SvJae * C57BL/6	abnormal cholesterol homeostasis	J:81363
	abnormal immune serum protein physiology	J:118971
	abnormal Langerhans cell physiology	J:112594
	abnormal lipid homeostasis	J:81363
	abnormal macrophage chemotaxis	J:44345
	abnormal microglial cell physiology	J:121703
	decreased airway responsiveness	J:118971
	decreased common myeloid progenitor cell number	J:44345
	decreased inflammatory response	J:44345
	decreased interferon-gamma secretion	J:44345, J:75838
	decreased interleukin-2 secretion	J:44345
	decreased interleukin-6 secretion	J:75838
	decreased splenocyte proliferation	J:75838
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:75838
	decreased susceptibility to type I hypersensitivity reaction	J:118971
	decreased T cell proliferation	J:75838
	hepatic necrosis	J:61542
	impaired macrophage chemotaxis	J:44345, J:81363, J:121703
	increased circulating alanine transaminase level	J:61542
	increased hepatocyte apoptosis	J:61542
	increased interferon-gamma secretion	J:61542
	increased physiological sensitivity to xenobiotic	J:61542
	increased tumor necrosis factor secretion	J:61542
	liver hemorrhage	J:61542
Ccr2tm1Ifc/Ccr2tm1Ifc involves: 129S4/SvJae * C57BL/6J	abnormal vascular wound healing	J:110790
Ccr2tm1Mae/Ccr2tm1Mae B6.129P2-Ccr2tm1Mae	abnormal Bruch membrane morphology	J:147328
	abnormal choriocapillaris morphology	J:147328
	abnormal conditioned taste aversion behavior	J:102583
	abnormal optic choroid morphology	J:147328
	abnormal retina pigment epithelium morphology	J:147328
	alcohol aversion	J:102583
	bronchiolitis	J:162707
	choroidal neovascularization	J:147328
	decreased alcohol consumption	J:102583
	decreased macrophage cell number	J:147328
	increased alcohol consumption	J:102583
	increased fluid intake	J:102583
	increased IgG level	J:147328
	increased susceptibility to age-related retinal degeneration	J:147328
	increased susceptibility to Coronaviridae infection	J:162707
	lipofuscinosis	J:147328
	retina deposits	J:147328
	retina outer nuclear layer degeneration	J:147328
	retina photoreceptor degeneration	J:147328
Ccr2tm1Mae/Ccr2tm1Mae involves: 129P2/OlaHsd	abnormal chemokine secretion	J:151874
	abnormal leukocyte migration	J:171379
	decreased circulating alanine transaminase level	J:311042
	decreased susceptibility to injury	J:311042
	impaired macrophage chemotaxis	J:151874, J:191510
Ccr2tm1Mae/Ccr2tm1Mae involves: 129P2/OlaHsd * BALB/c	abnormal leukocyte physiology	J:162714
	decreased circulating creatinine level	J:162714
	decreased neutrophil cell number	J:162714
	decreased susceptibility to kidney reperfusion injury	J:162714
	impaired macrophage chemotaxis	J:162714
Ccr2tm1Mae/Ccr2tm1Mae involves: 129P2/OlaHsd * C57BL/6J	abnormal cytokine secretion	J:110814
	decreased CD4-positive, alpha-beta T cell number	J:110814
	decreased inflammatory response	J:110814
	diarrhea	J:110814
	increased B cell number	J:110814
	increased CD8-positive, alpha-beta T cell number	J:110814
	increased susceptibility to induced colitis	J:110814
	weight loss	J:110814
Ccr2tm1Mpa/Ccr2tm1Mpa Lyz2tm1(cre)Ifo/Lyz2+ involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal wound healing	J:189044
	decreased macrophage cell number	J:189044