Ccr2^tm1.1Dnc
Targeted Allele Detail

Summary

• Symbol: Ccr2^tm1.1Dnc
• Name: C-C motif chemokine receptor 2; targeted mutation 1.1, Donald Cook
• MGI ID: MGI:5660875
• Gene: Ccr2 Location: Chr9:123901987-123913594 bp, + strand Genetic Position: Chr9, 75.05 cM, cytoband F
• Alliance: Ccr2^tm1.1Dnc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223508
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting construct containing DsRed (red fluorescent protein) sequence followed by a loxP-flanked neomycin resistance cassette was used to disrupt the coding region of the gene. RFP fluorescence is not detectable in targeted cells. Cre-mediated recombination removed the upstream floxed neo cassette. (J:223508)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccr2 Mutation: 40 strains or lines available

References

• Original: J:223508 Nakano H, et al., Migratory properties of pulmonary dendritic cells are determined by their developmental lineage. Mucosal Immunol. 2013 Jul;6(4):678-91
• All: 1 reference(s)