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Rab7
Gene Detail
Symbol

Name
ID
Rab7
RAB7, member RAS oncogene family
MGI:105068
Feature Type
protein coding gene
Genetic Map
Chromosome 6
39.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:87999106-88045270 bp, - strand
From VEGA annotation of GRCm38

  46165 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3408  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab7

Human
homologs
Human Homolog RAB7A, RAB7A, member RAS oncogene family
NCBI Gene ID 7879
neXtProt AC  NX_P51149
Human Synonyms  PRO2706, RAB7
Human Chr (Location)  3q21.3; chr3:128726136-128814798 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human RAB7A
Mutations,
alleles, and
phenotypes
All mutations/alleles(207) : Gene trapped(203) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted alleles exhibit abnormal endocytosis within the visceral endoderm, failure of elongation along the primitive streak and incomplete gastrulation.
 
Interactions
Rab7 interacts with 278 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (59 annotations)
Process bone resorption, early endosome to late endosome transport, ...
Component alveolar lamellar body, cell, ...
Function GDP binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (2)    Tissues (2)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(1) cDNA(18) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000024646 (Evidence)
Ensembl Gene ModelENSMUSG00000079477 (Evidence)
Entrez Gene19349 (Evidence)
DFCITC1724018, TC1573839
DoTSDT.101250852, DT.102559211, DT.101369141, DT.110485073, DT.102559213, DT.94250497, DT.496256, DT.99867815
NIA Mouse Gene IndexU030890, U027590
Consensus CDS ProjectCCDS39552.1
International Mouse Knockout Project StatusRab7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024646 VEGA Gene Model | MGI Sequence Detail 46165 C57BL/6J ±  kb
transcript OTTMUST00000060592 VEGA | MGI Sequence Detail 1859 Not Applicable 
polypeptide OTTMUSP00000029564 VEGA | MGI Sequence Detail 207 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(10) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(147 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003579 Small GTPase superfamily, Rab type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013639 ras-related protein Rab-7a
References
(Earliest) J:30249 Carroll JM, et al., Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis. Cell. 1995 Dec 15;83(6):957-68
(Latest) J:209071 Qin Y, et al., The tumor susceptibility gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal function. Hum Mol Genet. 2014 May 1;23(9):2428-39
All references(69)
Other
accession IDs
MGD-MRK-32107

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory