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Rab7
Gene Detail
 Symbol
Name
ID
Rab7
RAB7, member RAS oncogene family
MGI:105068
Feature Type protein coding gene
Genetic Map
Chromosome 6
39.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:87999106-88045270 bp, - strand
From VEGA annotation of GRCm38

  46165 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3408  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab7

Human
homologs
Human Homolog RAB7A, RAB7A, member RAS oncogene family
NCBI Gene ID 7879
neXtProt AC  NX_P51149
Human Synonyms  PRO2706, RAB7
Human Chr (Location)  3q21.3; chr3:128726136-128814798 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human RAB7A
Alleles
and
phenotypes
All alleles(207) : Gene trapped(203) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted alleles exhibit abnormal endocytosis within the visceral endoderm, failure of elongation along the primitive streak and incomplete gastrulation.
 
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process bone resorption, early endosome to late endosome transport, ...
Component alveolar lamellar body, cell, ...
Function GDP binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (2)    Tissues (2)    Images (1)
Theiler Stages: 19
Assay TypeResults
RNA in situ 2
cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(20) Genomic(1) cDNA(18) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000024646 (Evidence)
Ensembl Gene ModelENSMUSG00000079477 (Evidence)
Entrez Gene19349 (Evidence)
DFCITC1573839, TC1724018
DoTSDT.496256, DT.101250852, DT.101369141, DT.102559211, DT.102559213, DT.110485073, DT.94250497, DT.99867815
NIA Mouse Gene IndexU027590, U030890
Consensus CDS ProjectCCDS39552.1
International Mouse Knockout Project StatusRab7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024646 VEGA Gene Model | MGI Sequence Detail 46165 C57BL/6J ±  kb
transcript OTTMUST00000060593 VEGA | MGI Sequence Detail 1657 Not Applicable 
polypeptide OTTMUSP00000029565 VEGA | MGI Sequence Detail 207 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(10) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(147 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003579 Small GTPase superfamily, Rab type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013639 ras-related protein Rab-7a
References (Earliest) J:30249 Carroll JM, et al., Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis. Cell. 1995 Dec 15;83(6):957-68
(Latest) J:206933 Farg MA, et al., C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking. Hum Mol Genet. 2014 Feb 27;
All references(65)
Other
accession IDs
MGD-MRK-32107

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory