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Gpx1
Gene Detail
 Symbol
Name
ID
Gpx1
glutathione peroxidase 1
MGI:104887
Synonyms cellular GPx, CGPx, Gpx, GPx-1, GSHPx-1
Feature Type protein coding gene
Genetic Map
Chromosome 9
59.24 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr9:108339080-108340338 bp, + strand
From Ensembl annotation of GRCm38

  1259 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20155  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: glutathione peroxidase
Gene Tree: Gpx1

Human
homologs
Human Homolog GPX1, glutathione peroxidase 1
NCBI Gene ID 2876
neXtProt AC  NX_P07203
Human Synonyms  GPXD, GSHPX1
Human Chr (Location)  3p21.3; chr3:49357176-49358358 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GPX1
Mutations,
alleles, and
phenotypes
All mutations/alleles(46) : Gene trapped(39) Targeted(7)
 
Homozygotes for targeted null mutations show increased sensitivity to the oxidative stress agents paraquat and hydrogen peroxide and to ischemia/reperfusion and cold-induced brain injury. Mutants also show paradoxical bradykinin-induced vasoconstriction.
 
Interactions
Gpx1 interacts with 24 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (74 annotations)
Process angiogenesis involved in wound healing, apoptotic process, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function glutathione binding, glutathione peroxidase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (193)    Tissues (149)    Images (14)
Theiler Stages: 4, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 94
Northern blot 86
Western blot 6
RT-PCR 7
cDNA source data(1123)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(1134) Genomic(6) cDNA(1124) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000063856 (Evidence)
Entrez Gene14775 (Evidence)
UniGene1090
DFCITC1573685, TC1642639
DoTSDT.101361495, DT.101361808, DT.94253972, DT.94254080
NIA Mouse Gene IndexU011021
EC1.11.1.9
Consensus CDS ProjectCCDS23522.1
International Mouse Knockout Project StatusGpx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000063856 Ensembl Gene Model | MGI Sequence Detail 1259 C57BL/6J ±  kb
transcript ENSMUST00000082429 Ensembl | MGI Sequence Detail 1041 Not Applicable 
polypeptide ENSMUSP00000081010 Ensembl | MGI Sequence Detail 201 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(7 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000889 Glutathione peroxidase
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000008210 glutathione peroxidase 1
References (Earliest) J:8354 Chambers I, et al., The structure of the mouse glutathione peroxidase gene: the selenocysteine in the active site is encoded by the 'termination' codon, TGA. EMBO J. 1986 Jun;5(6):1221-7
(Latest) J:211847 Esworthy RS, et al., Nox1 causes ileocolitis in mice deficient in glutathione peroxidase-1 and -2. Free Radic Biol Med. 2014 Mar;68:315-25
All references(166)
Other
accession IDs
MGD-MRK-10238, MGD-MRK-29040, MGI:2142986, MGI:2143185

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory