Gpx1
Gene Detail

Symbol Name ID

Gpx1 glutathione peroxidase 1 MGI:104887

Synonyms

cellular GPx, CGPx, Gpx, GPx-1, GSHPx-1

Feature Type

protein coding gene

Genetic Map

Chromosome 9

59.24 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr9:108339080-108340338 bp, + strand From Ensembl annotation of GRCm38   1259 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20155  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: glutathione peroxidase
Gene Tree: Gpx1

Human homologs

Human Homolog		GPX1, glutathione peroxidase 1
NCBI Gene ID		2876
neXtProt AC		NX_P07203
Human Synonyms		GPXD, GSHPX1
Human Chr (Location)		3p21.3; chr3:49394609-49395791 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GPX1

Alleles and phenotypes

All alleles(45) : Targeted(6) Gene trapped(39)
 

Homozygotes for targeted null mutations show increased sensitivity to the oxidative stress agents paraquat and hydrogen peroxide and to ischemia/reperfusion and cold-induced brain injury. Mutants also show paradoxical bradykinin-induced vasoconstriction.

 

Gene Ontology (GO) classifications

All GO classifications: (73 annotations)

Process	angiogenesis involved in wound healing, apoptotic process, ...
Component	cytoplasm, mitochondrion, ...
Function	endopeptidase inhibitor activity, glutathione binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (194)    Tissues (144)    Images (14)
Theiler Stages: 4, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	94
Northern blot	86
Western blot	6
RT-PCR	8

cDNA source data(1115)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(1126) Genomic(6) cDNA(1116) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000063856 (Evidence)
Entrez Gene	14775 (Evidence)
UniGene	1090
DFCI	TC1573685, TC1642639
DoTS	DT.101361495, DT.101361808, DT.94253972, DT.94254080
NIA Mouse Gene Index	U011021
EC	1.11.1.9
Consensus CDS Project	CCDS23522.1
International Mouse Knockout Project Status	Gpx1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000063856	Ensembl Gene Model | MGI Sequence Detail	1259	C57BL/6J
transcript	ENSMUST00000082429	Ensembl | MGI Sequence Detail	1041	Not Applicable
polypeptide	ENSMUSP00000081010	Ensembl | MGI Sequence Detail	201	Not Applicable

All sequences(36) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(6 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000889	Glutathione peroxidase
InterPro	IPR012336	Thioredoxin-like fold
Protein Ontology	PR:000008210	glutathione peroxidase 1

References

(Earliest) J:8354 Chambers I, et al., The structure of the mouse glutathione peroxidase gene: the selenocysteine in the active site is encoded by the 'termination' codon, TGA. EMBO J. 1986 Jun;5(6):1221-7
(Latest) J:192636 Hill KE, et al., Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis. J Biol Chem. 2012 Nov 23;287(48):40414-24
All references(158)

Other accession IDs

MGD-MRK-10238, MGD-MRK-29040, MGI:2142986, MGI:2143185