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Gpx4
Gene Detail
Symbol

Name
ID
Gpx4
glutathione peroxidase 4
MGI:104767
Synonyms
1700027O09Rik, mtPHGPx, PHGPx, phospholipid hydroperoxide glutathione peroxidase, snGPx, sperm nuclei glutathione peroxidase
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:80047166-80056439 bp, + strand
From VEGA annotation of GRCm38

  9274 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134384  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GPX4
Protein SuperFamily: glutathione peroxidase
Gene Tree: Gpx4

Human
homologs
GPX4, glutathione peroxidase 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2879
neXtProt AC: NX_P36969

Human Synonyms: GPx-4, GSHPx-4, MCSP, PHGPx, snGPx, snPHGPx

Human Chr (Location): 19p13.3; chr19:1103926-1106789 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(221) : Gene trapped(210) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Gastrulation is impaired and homozygous mutant embryos consequently die during early embryonic development.
 
Interactions
Gpx4 interacts with 19 markers (Mir29b-1, Mir29b-2, Mir34b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process chromatin organization, glutathione metabolic process, ...
Component cytoplasm, cytosol, ...
Function glutathione binding, glutathione peroxidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (363)    Tissues (233)    Images (41)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 275
RT-PCR 88
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) Genomic(1) cDNA(22) Primer pair(7)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000019111 (Evidence)
Ensembl Gene Model ENSMUSG00000075706 (Evidence)
Entrez Gene 625249 (Evidence)
DFCI TC1574002, TC1589224
DoTS DT.101258442, DT.101311532, DT.101370183, DT.103586422, DT.103586423, DT.110629530, DT.496759, DT.94278628, DT.99871330
NIA Mouse Gene Index U011490, U361881
EC 1.11.1.12
Consensus CDS Project CCDS24007.1, CCDS35973.1
International Mouse Phenotyping Consortium Status Gpx4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019111 VEGA Gene Model | MGI Sequence Detail 9274 C57BL/6J ±  kb
transcript OTTMUST00000045763 VEGA | MGI Sequence Detail 995 Not Applicable 
polypeptide OTTMUSP00000020606 VEGA | MGI Sequence Detail 253 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(5) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(34 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000889 Glutathione peroxidase
InterPro IPR029759 Glutathione peroxidase active site
InterPro IPR029760 Glutathione peroxidase conserved site
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000008213 phospholipid hydroperoxide glutathione peroxidase
References
(Earliest) J:19723 Nishiguchi S, et al., A survey of genes expressed in undifferentiated mouse embryonal carcinoma F9 cells: characterization of low-abundance mRNAs. J Biochem. 1994 Jul;116(1):128-39
(Latest) J:222639 Matsushita M, et al., T cell lipid peroxidation induces ferroptosis and prevents immunity to infection. J Exp Med. 2015 Apr 6;212(4):555-68
All references(79)
Other
accession IDs
MGD-MRK-28058

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory