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Gpx4
Gene Detail
 Symbol
Name
ID
Gpx4
glutathione peroxidase 4
MGI:104767
Synonyms 1700027O09Rik, mtPHGPx, PHGPx, phospholipid hydroperoxide glutathione peroxidase, snGPx, sperm nuclei glutathione peroxidase
Feature Type protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:80047166-80056439 bp, + strand
From VEGA annotation of GRCm38

  9274 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134384  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: glutathione peroxidase
Gene Tree: Gpx4

Human
homologs
Human Homolog GPX4, glutathione peroxidase 4
NCBI Gene ID 2879
neXtProt AC  NX_P36969
Human Synonyms  GPx-4, GSHPx-4, MCSP, PHGPx, snGPx, snPHGPx
Human Chr (Location)  19p13.3; chr19:1103937-1106788 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(221) : Gene trapped(210) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Gastrulation is impaired and homozygous mutant embryos consequently die during early embryonic development.
 
Interactions
Gpx4 interacts with 19 markers (Mir29b-1, Mir29b-2, Mir34b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process chromatin organization, glutathione metabolic process, ...
Component cytoplasm, cytosol, ...
Function glutathione binding, glutathione peroxidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (363)    Tissues (233)    Images (41)
Theiler Stages: 9, 11, 13, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 275
RT-PCR 88
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) Genomic(1) cDNA(22) Primer pair(7)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000019111 (Evidence)
Ensembl Gene ModelENSMUSG00000075706 (Evidence)
Entrez Gene625249 (Evidence)
DFCITC1574002, TC1589224
DoTSDT.101258442, DT.101311532, DT.101370183, DT.103586422, DT.103586423, DT.110629530, DT.496759, DT.94278628, DT.99871330
NIA Mouse Gene IndexU011490, U361881
EC1.11.1.12
Consensus CDS ProjectCCDS24007.1, CCDS35973.1
International Mouse Knockout Project StatusGpx4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019111 VEGA Gene Model | MGI Sequence Detail 9274 C57BL/6J ±  kb
transcript OTTMUST00000045763 VEGA | MGI Sequence Detail 995 Not Applicable 
polypeptide OTTMUSP00000020606 VEGA | MGI Sequence Detail 253 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(5) UniProt(7)
Polymorphisms RFLP(1) : SNPs within 2kb(34 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000889 Glutathione peroxidase
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000008213 phospholipid hydroperoxide glutathione peroxidase
References (Earliest) J:19723 Nishiguchi S, et al., A survey of genes expressed in undifferentiated mouse embryonal carcinoma F9 cells: characterization of low-abundance mRNAs. J Biochem. 1994 Jul;116(1):128-39
(Latest) J:198008 Sengupta A, et al., Targeted Disruption of Glutathione Peroxidase 4 in Mouse Skin Epithelial Cells Impairs Postnatal Hair Follicle Morphogenesis that Is Partially Rescued through Inhibition of COX-2. J Invest Dermatol. 2013 Jul;133(7):1731-41
All references(76)
Other
accession IDs
MGD-MRK-28058

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory