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Gpx4 Gene Detail
Summary
  • Symbol
    Gpx4
  • Name
    glutathione peroxidase 4
  • Synonyms
    1700027O09Rik, mtPHGPx, PHGPx, phospholipid hydroperoxide glutathione peroxidase, snGPx, sperm nuclei glutathione peroxidase
  • Feature Type
    protein coding gene
  • IDs
    MGI:104767
    NCBI Gene: 625249
  • Gene Overview
    MyGene.info: GPX4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:80047166-80056439 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9274 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    GPX4, glutathione peroxidase 4
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GPX4, glutathione peroxidase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GPx-4, GSHPx-4, MCSP, PHGPx, SMDS, snGPx, snPHGPx
  • Links
    NCBI Gene ID: 2879
    neXtProt AC: NX_P36969
    UniProt: P36969

  • Chr Location
    19p13.3; chr19:1103926-1106789 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    44 phenotypes from 9 alleles in 9 genetic backgrounds
    2 images
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gastrulation is impaired and homozygous mutant embryos consequently die during early embryonic development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000019111 VEGA Gene Model | MGI Sequence Detail 9274 C57BL/6J ±  kb
    transcript OTTMUST00000045763 VEGA | MGI Sequence Detail 995 Not Applicable  
    polypeptide OTTMUSP00000020606 VEGA | MGI Sequence Detail 253 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      32 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 1
      cDNA 24
      Primer pair 12

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-28058
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 14
      Gene Ontology 14
      Phenotypes 42
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:255340 Ingold I, et al., Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis. Cell. 2018 Jan 25;172(3):409-422.e21

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory