Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables glutathione peroxidase activity and phospholipid-hydroperoxide glutathione peroxidase activity. Involved in negative regulation of ferroptosis and response to oxidative stress. Acts upstream of or within chromatin organization and spermatogenesis. Located in cytosol; mitochondrion; and nuclear envelope. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; colorectal cancer; and spondylometaphyseal dysplasia Sedaghatian type. Orthologous to human GPX4 (glutathione peroxidase 4).