Sequence Detail

ID/Version

O70325 Q91XR9 Q8K4U8 Q9JK35 O35560 (UniProt | EBI)

Last sequence update: 2008-02-26
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Phospholipid hydroperoxide glutathione peroxidase GPX4 {ECO:0000303|PubMed:12745070, ECO:0000303|PubMed:9370288}; Short=PHGPx {ECO:0000303|PubMed:12745070, ECO:0000303|PubMed:9370288}; EC=1.11.1.12 {ECO:0000269|PubMed:2929046

Provider

SWISS-PROT

Sequence

Polypeptide 197 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gpx4	glutathione peroxidase 4	38	141	4	205

Sequence references in MGI

J:43287 Nam S, et al., Cloning and sequencing of the mouse cDNA encoding a phospholipid hydroperoxide glutathione peroxidase. Gene. 1997 Oct 1;198(1-2):245-9
J:53501 Borchert A, et al., Cloning of the mouse phospholipid hydroperoxide glutathione peroxidase gene. FEBS Lett. 1999 Mar 12;446(2-3):223-7
J:55082 Knopp EA, et al., Murine phospholipid hydroperoxide glutathione peroxidase: cDNA sequence, tissue expression, and mapping. Mamm Genome. 1999 Jun;10(6):601-5
J:69361 Pfeifer H, et al., Identification of a specific sperm nuclei selenoenzyme necessary for protamine thiol cross-linking during sperm maturation. FASEB J. 2001 May;15(7):1236-8
J:82053 Yant LJ, et al., The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. Free Radic Biol Med. 2003 Feb 15;34(4):496-502
J:83472 Imai H, et al., Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene. Biochem Biophys Res Commun. 2003 May 30;305(2):278-86
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:139668 Seiler A, et al., Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab. 2008 Sep;8(3):237-48
J:156326 Imai H, et al., Depletion of selenoprotein GPx4 in spermatocytes causes male infertility in mice. J Biol Chem. 2009 Nov 20;284(47):32522-32
J:158033 Wirth EK, et al., Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration. FASEB J. 2010 Mar;24(3):844-52
J:182776 Ueta T, et al., Glutathione peroxidase 4 is required for maturation of photoreceptor cells. J Biol Chem. 2012 Mar 2;287(10):7675-82
J:186906 Schneider M, et al., Mitochondrial glutathione peroxidase 4 disruption causes male infertility. FASEB J. 2009 Sep;23(9):3233-42
J:217747 Friedmann Angeli JP, et al., Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014 Dec;16(12):1180-91
J:222639 Matsushita M, et al., T cell lipid peroxidation induces ferroptosis and prevents immunity to infection. J Exp Med. 2015 Apr 6;212(4):555-68
J:225651 Ingold I, et al., Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility. J Biol Chem. 2015 Jun 5;290(23):14668-78
J:255340 Ingold I, et al., Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis. Cell. 2018 Jan 25;172(3):409-422.e21
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:302022 Wirth EK, et al., Cerebellar hypoplasia in mice lacking selenoprotein biosynthesis in neurons. Biol Trace Elem Res. 2014 May;158(2):203-10