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Ppara Gene Detail
Summary
  • Symbol
    Ppara
  • Name
    peroxisome proliferator activated receptor alpha
  • Synonyms
    4933429D07Rik, Nr1c1, Ppar, PPARalpha, PPAR-alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:104740
    NCBI Gene: 19013
Location & Maps
more
  • Sequence Map
    Chr15:85734983-85802819 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      67837 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 40.42 cM
  • Mapping Data
    17 experiments
Homology
more
  • Human Ortholog
    PPARA, peroxisome proliferator activated receptor alpha
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PPARA, peroxisome proliferator activated receptor alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hPPAR, NR1C1, PPAR, PPARalpha
  • Links
    NCBI Gene ID: 5465
    neXtProt AC: NX_Q07869

  • Chr Location
    22q13.31; chr22:46150547-46243756 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PPARA associations

Human Disease Mouse Models
       Peroxisome Proliferator-Activated Receptor-Alpha; PPARA   OMIM: 170998
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    55 phenotypes from 5 alleles in 8 genetic backgrounds
    4 phenotypes from multigenic genotypes
    2 images
    307 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    4
  • Transgenic
    4
  • Genomic Mutations
    3 involving Ppara
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit loss of diurnal variation in hepatic fatty acid and cholesterol synthesis, increased hepatic lipid and gonadal adipose stores, impaired skin wound healing, and altered metabolic responses to starvation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023590 VEGA Gene Model | MGI Sequence Detail 67837 C57BL/6J ±  kb
transcript OTTMUST00000057581 VEGA | MGI Sequence Detail 3413 Not Applicable  
polypeptide OTTMUSP00000027777 VEGA | MGI Sequence Detail 468 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    858 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000013056 peroxisome proliferator-activated receptor alpha
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR003074 Peroxisome proliferator-activated receptor
    IPR003076 Peroxisome proliferator-activated receptor, alpha
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
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  • All nucleic 55
    Genomic 4
    cDNA 43
    Primer pair 6
    Other 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-13588, MGD-MRK-28031, MGI:2145949, MGI:2146246, MGI:3026969
References
more
  • Summaries
    All 454
    Developmental Gene Expression 39
    Diseases 1
    Gene Ontology 26
    Phenotypes 307
  • Earliest
    J:10775 Issemann I, et al., Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators [see comments]. Nature. 1990 Oct 18;347(6294):645-50
  • Latest
    J:236457 Wang A, et al., Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation. Cell. 2016 Sep 8;166(6):1512-1525.e12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory