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Ppara Gene Detail
Summary
  • Symbol
    Ppara
  • Name
    peroxisome proliferator activated receptor alpha
  • Synonyms
    4933429D07Rik, Nr1c1, Ppar, PPARalpha, PPAR-alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:104740
    NCBI Gene: 19013
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:85734983-85802819 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 40.42 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    858 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104740
protein coding gene Chr15:85734628-85806851 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022194
protein coding gene Chr15:86636695-86713025 (+)
A/J MGP_AJ_G0022153
protein coding gene Chr15:83401204-83471275 (+)
AKR/J MGP_AKRJ_G0022128
protein coding gene Chr15:85868740-85939217 (+)
BALB/cJ MGP_BALBcJ_G0022159
protein coding gene Chr15:83527881-83596759 (+)
C3H/HeJ MGP_C3HHeJ_G0021929
protein coding gene Chr15:85803114-85877166 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022604
protein coding gene Chr15:89883354-89956391 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020129
protein coding gene Chr15:79722279-79790076 (+)
CAST/EiJ MGP_CASTEiJ_G0021451
protein coding gene Chr15:86612845-86685721 (+)
CBA/J MGP_CBAJ_G0021896
protein coding gene Chr15:92866726-92957426 (+)
DBA/2J MGP_DBA2J_G0022023
protein coding gene Chr15:82864052-82932983 (+)
FVB/NJ MGP_FVBNJ_G0022002
protein coding gene Chr15:81937803-82011480 (+)
LP/J MGP_LPJ_G0022094
protein coding gene Chr15:86805307-86877284 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022022
protein coding gene Chr15:97542057-97618120 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022619
protein coding gene Chr15:85860871-85938116 (+)
PWK/PhJ MGP_PWKPhJ_G0021192
protein coding gene Chr15:82878721-82948710 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021026
protein coding gene Chr15:85570279-85649428 (+)
WSB/EiJ MGP_WSBEiJ_G0021500
protein coding gene Chr15:86366089-86434981 (+)



Homology
more
  • Human Ortholog
    PPARA, peroxisome proliferator activated receptor alpha
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PPARA, peroxisome proliferator activated receptor alpha
    Orthology source: HGNC, HomoloGene
  • Synonyms
    hPPAR, NR1C1, PPAR, PPARalpha
  • Links
    NCBI Gene ID: 5465
    neXtProt AC: NX_Q07869
    UniProt: Q07869

  • Chr Location
    22q13.31; chr22:46150534-46243756 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Ppara mouse models

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    56 phenotypes from 5 alleles in 8 genetic backgrounds
    4 phenotypes from multigenic genotypes
    2 images
    335 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit loss of diurnal variation in hepatic fatty acid and cholesterol synthesis, increased hepatic lipid and gonadal adipose stores, impaired skin wound healing, and altered metabolic responses to starvation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022383 Ensembl Gene Model | MGI Sequence Detail 67837 C57BL/6J ±  kb
    transcript ENSMUST00000109423 Ensembl | MGI Sequence Detail 2519 Not Applicable  
    polypeptide ENSMUSP00000105050 Ensembl | MGI Sequence Detail 468 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000013056 peroxisome proliferator-activated receptor alpha
    • InterPro Domains
      IPR001723 Nuclear hormone receptor
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR003074 Peroxisome proliferator-activated receptor
      IPR003076 Peroxisome proliferator-activated receptor alpha
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    Molecular
    Reagents
    less
    • All nucleic 58
      Genomic 4
      cDNA 44
      Primer pair 7
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13588, MGD-MRK-28031, MGI:2145949, MGI:2146246, MGI:3026969
    References
    more
    • Summaries
      All 577
      Developmental Gene Expression 44
      Diseases 2
      Gene Ontology 28
      Phenotypes 335
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:265893 Regnier M, et al., Insights into the role of hepatocyte PPARalpha activity in response to fasting. Mol Cell Endocrinol. 2018 Aug 15;471:75-88

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory