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Ppara Gene Detail
Summary
  • Symbol
    Ppara
  • Name
    peroxisome proliferator activated receptor alpha
  • Synonyms
    4933429D07Rik, Nr1c1, Ppar, PPAR-alpha, PPARalpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:104740
    NCBI Gene: 19013
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:85619184-85687020 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 40.42 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1902 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104740
 protein coding gene Chr15:85619112-85691052 (+)
129S1/SvImJ ENSMUSG00200035590
 protein coding gene Chr15:82745737-82817608 (+)
A/J ENSMUSG00195018919
 protein coding gene Chr15:82672848-82744216 (+)
AKR/J ENSMUSG00220027206
 protein coding gene Chr15:82725874-82797430 (+)
BALB/cJ ENSMUSG00180014734
 protein coding gene Chr15:82548915-82620802 (+)
C3H/HeJ ENSMUSG00175027687
 protein coding gene Chr15:82860245-82931798 (+)
C57BL/6NJ ENSMUSG00215013392
 protein coding gene Chr15:82638881-82710405 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020129
 protein coding gene Chr15:79722279-79790076 (+)
CAST/EiJ ENSTCUG00005029272
 protein coding gene Chr15:82138868-82212449 (+)
CBA/J ENSMUSG00210012990
 protein coding gene Chr15:82635132-82706688 (+)
DBA/2J ENSMUSG00185021477
 protein coding gene Chr15:82661031-82732586 (+)
FVB/NJ ENSMUSG00205033999
 protein coding gene Chr15:82421261-82492832 (+)
JF1/MsJ ENSUMUG00000025697
 protein coding gene Chr15:82178396-82250423 (+)
LP/J ENSMUSG00230043135
 protein coding gene Chr15:85985906-86057765 (+)
NOD/ShiLtJ ENSMUSG00190021874
 protein coding gene Chr15:82658623-82730175 (+)
NZO/HlLtJ ENSMUSG00225049557
 protein coding gene Chr15:86324417-86396286 (+)
PWK/PhJ ENSLUMG00010029216
 protein coding gene Chr15:82385277-82457090 (+)
SPRET/EiJ ENSMSPG00010013855
 protein coding gene Chr15:84044010-84111673 (+)
WSB/EiJ ENSIUOG00005010951
 protein coding gene Chr15:82725708-82796766 (+)



Homology
more
  • Human Ortholog
    PPARA, peroxisome proliferator activated receptor alpha
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPARA, peroxisome proliferator activated receptor alpha
  • Synonyms
    hPPAR, NR1C1, PPAR, PPAR-alpha, PPARalpha
  • Links
    NCBI Gene ID: 5465
    UniProt: Q07869

  • Chr Location
    22q13.31; chr22:46149924-46243756 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Ppara mouse models; 5 with human PPARA associations

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    66 phenotypes from 7 alleles in 11 genetic backgrounds
    7 phenotypes from multigenic genotypes
    2 images
    488 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit loss of diurnal variation in hepatic fatty acid and cholesterol synthesis, increased hepatic lipid and gonadal adipose stores, impaired skin wound healing, and altered metabolic responses to starvation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    185
  • GO References
    40
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    967
  • Tissues
    211
  • cDNA Data
    43
  • Literature Summary
    72
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022383 Ensembl Gene Model | MGI Sequence Detail 67837 C57BL/6J ±  kb
    transcript ENSMUST00000109423 Ensembl | MGI Sequence Detail 2519 Not Applicable  
    polypeptide ENSMUSP00000105050 Ensembl | MGI Sequence Detail 468 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000013056 peroxisome proliferator-activated receptor alpha
      (term hierarchy)
    • InterPro Domains
      IPR001723 Nuclear hormone receptor
      IPR050234 Nuclear hormone receptor family NR1 subfamily
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR003074 Peroxisome proliferator-activated receptor
      IPR003076 Peroxisome proliferator-activated receptor alpha
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    Molecular
    Reagents
    less
    • All nucleic 67
      Genomic 4
      cDNA 44
      Primer pair 16
      Other 3
      Antibodies 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13588, MGD-MRK-28031, MGI:2145949, MGI:2146246, MGI:3026969
    References
    more
    • Summaries
      All 847
      Developmental Gene Expression 72
      Diseases 3
      Gene Ontology 40
      Phenotypes 488
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:391697 Aomura D, et al., Proximal Tubule-Specific Genetic Deficiency of PPARalpha Worsens Systemic Lipid and Glucose Metabolism During Fasting. FASEB J. 2026 Jan 15;40(1):e71333
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory