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Ppara
Gene Detail
Symbol

Name
ID
Ppara
peroxisome proliferator activated receptor alpha
MGI:104740
Synonyms
4933429D07Rik, Nr1c1, Ppar, PPARalpha, PPAR-alpha
Feature Type
protein coding gene
Genetic Map
Chromosome 15
40.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr15:85734983-85802819 bp, + strand
From VEGA annotation of GRCm38

  67837 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21047  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: PPARA
Protein SuperFamily: peroxisome proliferator activated receptor (PPAR)
Gene Tree: Ppara

Human
homologs
PPARA, peroxisome proliferator-activated receptor alpha
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5465
neXtProt AC: NX_Q07869

Human Synonyms: hPPAR, NR1C1, PPAR, PPARalpha

Human Chr (Location): 22q13.31; chr22:46150547-46243756 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PPARA

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Radiation induced(1) Targeted(4) Transgenic(3)
Genomic Mutations involving Ppara (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit loss of diurnal variation in hepatic fatty acid and cholesterol synthesis, increased hepatic lipid and gonadal adipose stores, impaired skin wound healing, and altered metabolic responses to starvation.
 
Phenotype Images(4)
Interactions
Ppara interacts with 234 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (81 annotations)
Process behavioral response to nicotine, circadian regulation of gene expression, ...
Component nucleus
Function DNA binding, drug binding, ...
External Resources: FuncBase
Expression
Literature Summary: (37 records)
Data Summary: Results (203)    Tissues (174)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 142
Northern blot 23
Western blot 1
RT-PCR 37
cDNA source data(42)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ppara ; ZFIN pparaa, pparab    NEW 
Molecular
reagents
All nucleic(55) Genomic(4) cDNA(43) Primer pair(6) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000023590 (Evidence)
Ensembl Gene Model ENSMUSG00000022383 (Evidence)
Entrez Gene 19013 (Evidence)
UniGene 212789
DFCI TC1582677, TC1602185, TC1698066
DoTS DT.101359164, DT.40164726, DT.487243, DT.60100211, DT.97400920, DT.99842163
Consensus CDS Project CCDS27721.1
International Mouse Phenotyping Consortium Status Ppara
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023590 VEGA Gene Model | MGI Sequence Detail 67837 C57BL/6J ±  kb
transcript OTTMUST00000057581 VEGA | MGI Sequence Detail 3413 Not Applicable 
polypeptide OTTMUSP00000027777 VEGA | MGI Sequence Detail 468 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(24) UniProt(2)
Polymorphisms
RFLP(3) : SNPs within 2kb(891 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001723 Nuclear hormone receptor
InterPro IPR000536 Nuclear hormone receptor, ligand-binding domain
InterPro IPR003074 Peroxisome proliferator-activated receptor
InterPro IPR003076 Peroxisome proliferator-activated receptor, alpha
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000013056 peroxisome proliferator-activated receptor alpha
References
(Earliest) J:10775 Issemann I, et al., Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators [see comments]. Nature. 1990 Oct 18;347(6294):645-50
(Latest) J:220678 Gao Q, et al., PPARalpha-Deficient ob/ob Obese Mice Become More Obese and Manifest Severe Hepatic Steatosis Due to Decreased Fatty Acid Oxidation. Am J Pathol. 2015 May;185(5):1396-408
All references(435)
Other
accession IDs
MGD-MRK-13588, MGD-MRK-28031, MGI:2145949, MGI:2146246, MGI:3026969

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory