Ppara^em1Tyrb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ppara^em1Tyrb
• Name: peroxisome proliferator activated receptor alpha; endonuclease-mediated mutation 1, Takeo Yoshikawa
• MGI ID: MGI:6810185
• Gene: Ppara Location: Chr15:85619184-85687020 bp, + strand Genetic Position: Chr15, 40.42 cM
• Alliance: Ppara^em1Tyrb page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 733-bp deletion spanning exon 3 and the flanking intronic regions. (J:313946)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ppara Mutation: 42 strains or lines available

References

• Original: J:313946 Wada Y, et al., Peroxisome proliferator-activated receptor alpha as a novel therapeutic target for schizophrenia. EBioMedicine. 2020 Dec;62:103130
• All: 1 reference(s)