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Tg(Myh6-Ppara)404-3Dpk
Transgene Detail
Summary
Symbol: Tg(Myh6-Ppara)404-3Dpk
Name: transgene insertion 404-3, Daniel P Kelly
MGI ID: MGI:3641575
Synonyms: MHC-PPAR, MHC-PPARalpha
Transgene: Tg(Myh6-Ppara)404-3Dpk  Location: unknown  
Alliance: Tg(Myh6-Ppara)404-3Dpk page
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA/J)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-Ppara)404-3Dpk expresses 1 gene
 
Mutation detailsThis transgene consists of a 1.5-kb, NH2-terminal FLAG epitope-tagged Ppara cDNA downstream of the cardiac alpha myosin heavy chain promoter. This line exhibits Ppara protein levels about 135-fold more abundant in cardiac ventricles than in nontransgenics. (J:110580)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:110580 Finck BN, et al., The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus. J Clin Invest. 2002 Jan;109(1):121-30
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory