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Myo7a Gene Detail
Summary
  • Symbol
    Myo7a
  • Name
    myosin VIIA
  • Synonyms
    Hdb, Myo7, myosin 7A, nmf371, polka, USH1B
  • Feature Type
    protein coding gene
  • IDs
    MGI:104510
    NCBI Gene: 17921
  • Alliance
    genome feature page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:97700267-97768731 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 53.57 cM
  • Mapping Data
    40 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2255 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104510
 protein coding gene Chr7:97700261-97768731 (-)
129S1/SvImJ ENSMUSG00200048536
 protein coding gene Chr7:84525116-84591807 (-)
A/J ENSMUSG00195036405
 protein coding gene Chr7:89030068-89096745 (-)
AKR/J ENSMUSG00220047197
 protein coding gene Chr7:82447361-82514052 (-)
BALB/cJ ENSMUSG00180027357
 protein coding gene Chr7:85703479-85770161 (-)
C3H/HeJ ENSMUSG00175023013
 protein coding gene Chr7:86351675-86418788 (-)
C57BL/6NJ ENSMUSG00215032292
 protein coding gene Chr7:85543145-85609859 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030011
 protein coding gene Chr7:100733371-100802193 (-)
CAST/EiJ ENSTCUG00005030113
 protein coding gene Chr7:88930430-88996758 (-)
CBA/J ENSMUSG00210025042
 protein coding gene Chr7:86199601-86266725 (-)
DBA/2J ENSMUSG00185032026
 protein coding gene Chr7:90526359-90593484 (-)
FVB/NJ ENSMUSG00205018283
 protein coding gene Chr7:86201825-86268519 (-)
JF1/MsJ ENSUMUG00000024392
 protein coding gene Chr7:95425157-95492257 (-)
LP/J ENSMUSG00230037198
 protein coding gene Chr7:96642128-96708801 (-)
NOD/ShiLtJ ENSMUSG00190017332
 protein coding gene Chr7:86476686-86543374 (-)
NZO/HlLtJ ENSMUSG00225048010
 protein coding gene Chr7:94828564-94895250 (-)
PWK/PhJ ENSLUMG00010046123
 protein coding gene Chr7:84647573-84714445 (-)
SPRET/EiJ ENSMSPG00010009901
 protein coding gene Chr7:85887939-85956719 (-)
WSB/EiJ ENSIUOG00005009597
 protein coding gene Chr7:86811392-86878202 (-)



Homology
more
  • Human Ortholog
    MYO7A, myosin VIIA
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYO7A, myosin VIIA
  • Synonyms
    DFNA11, DFNB2, MYOVIIA, MYU7A, NSRD2, USH1B
  • Links
    NCBI Gene ID: 4647
    UniProt: Q13402

  • Chr Location
    11q13.5; chr11:77128245-77215241 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Myo7a mouse models; 7 with human MYO7A associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 13 models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    14 with disease annotations
  • References
    12 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    86 phenotypes from 21 alleles in 23 genetic backgrounds
    11 phenotypes from multigenic genotypes
    12 images
    97 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A number of spontaneous and ENU-induced mutations cause head-shaking, circling and deafness, often associated with cochlear hair cell degeneration and stereocilia anomalies. Defects in retinal pigment epithelial cells, male infertility, and light-inducedphotoreceptor damage have also been observed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    153
  • GO References
    53
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2027
  • Tissues
    256
  • cDNA Data
    33
  • Literature Summary
    263
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030761 Ensembl Gene Model | MGI Sequence Detail 68465 C57BL/6J ±  kb
    transcript ENSMUST00000107128 Ensembl | MGI Sequence Detail 7506 Not Applicable  
    polypeptide ENSMUSP00000102745 Ensembl | MGI Sequence Detail 2215 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      Genomic 6
      cDNA 34
      Primer pair 7
      Other 2
      Antibodies 38

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14391, MGD-MRK-14393, MGD-MRK-25940, MGD-MRK-25941, MGI:1891335, MGI:3587416, MGI:3708140
    References
    more
    • Summaries
      All 464
      Developmental Gene Expression 263
      Diseases 12
      Gene Ontology 53
      Phenotypes 97
    • Earliest
      J:95 Gates WH, Linkage of the characters albinism and shaker in the house mouse. Anat Rec. 1929;41:104 (S28 Abstr.)
    • Latest
      J:390448 Li S, et al., Tonotopic specialization of MYO7A isoforms in auditory hair cells. Nat Commun. 2026 Jun 3;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory