About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5312616
Allelic
Composition
Myo7ash1-11J/Myo7ash1-11J
Genetic
Background
129.B6-Myo7ash1-11J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo7ash1-11J mutation (1 available); any Myo7a mutation (77 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mutants exposed to moderate intensity light show an accumulation of superoxide in rods at a level 3.5 times greater than in wild-type mice
• mutants exhibit rod photoreceptor degeneration in response to moderate intensity light exposure that is not seen in wild-type mice
• mutants reared under a moderate light/dark cycle, but not dim/dark cycle conditions, develop severe retinal degeneration in less than 6 months

vision/eye
• mutants exposed to moderate intensity light show an accumulation of superoxide in rods at a level 3.5 times greater than in wild-type mice
• mutants exhibit rod photoreceptor degeneration in response to moderate intensity light exposure that is not seen in wild-type mice
• mutants reared under a moderate light/dark cycle, but not dim/dark cycle conditions, develop severe retinal degeneration in less than 6 months

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Usher syndrome type 1 DOID:0110826 OMIM:276900
J:181430


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
01/24/2023
MGI 6.22
The Jackson Laboratory