About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6405698
Allelic
Composition
Myo7atm1b(EUCOMM)Wtsi/Myo7atm1b(EUCOMM)Wtsi
Genetic
Background
B6J.Cg-Myo7atm1b(EUCOMM)Wtsi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo7atm1b(EUCOMM)Wtsi mutation (0 available); any Myo7a mutation (77 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• mice show near complete loss of both inner and outer hair cells in the middle and basal cochlear regions
• mice show reduced stria vascularis thickness or atrophy in the basal cochlea
• degeneration of cochlear structure
• however, vestibular hair cells are preserved in 5 month old mice
• males and females exhibit profound hearing loss across all frequencies

vision/eye
• eyes do not dilate as quickly as controls
• scotopic and photopic amplitudes are only modestly reduced after 1 month of age and are reduced by about 20% by 6 months
• however, no gross structural changes are seen in the retina, with normal outer nuclear layer thickness
• scotopic a-wave amplitude is modestly reduced after 2 months of age
• scotopic and photopic b-wave amplitudes are modestly reduced after 2 months of age

behavior/neurological
• eyes do not dilate as quickly as controls

nervous system
• mice show near complete loss of both inner and outer hair cells in the middle and basal cochlear regions
• mice show near complete loss of spiral ganglion neurons

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Usher syndrome type 1 DOID:0110826 OMIM:276900
J:283233


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
01/24/2023
MGI 6.22
The Jackson Laboratory