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Nova2
Gene Detail
 Symbol
Name
ID
Nova2
neuro-oncological ventral antigen 2
MGI:104296
Synonyms LOC384569
Feature Type protein coding gene
Genetic Map
Chromosome 7
9.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:18925888-18962057 bp, + strand
From VEGA annotation of GRCm38

  36170 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134398  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle

Gene Tree: Nova2

Human
homologs
Human Homolog NOVA2, neuro-oncological ventral antigen 2
NCBI Gene ID 4858
neXtProt AC  NX_Q9UNW9
Human Synonyms  ANOVA, NOVA3
Human Chr (Location)  19q13.3; chr19:45933734-45973399 (-)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Gene trapped(1) Targeted(3)
 
Homozygous mutation of this gene results in postnatal lethality, abolished long term potentiation of the small inhibitory postsynaptic current but not the excitatory postsynaptic current, and no pairing-induced potentiation of small inhibitory postsynatpic currents.
 
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process regulation of RNA metabolic process
Function poly(A) RNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (248)    Tissues (80)    Images (41)
Theiler Stages: 19, 21, 22, 23, 25, 28
Assay TypeResults
Immunohistochemistry 14
RNA in situ 221
Northern blot 5
Western blot 6
RT-PCR 2
cDNA source data(37)
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(38) cDNA(37) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000036901 (Evidence)
Ensembl Gene ModelENSMUSG00000030411 (Evidence)
Entrez Gene384569 (Evidence)
UniGene262724
DFCITC1601264, TC1605157, TC1662248
DoTSDT.101159879, DT.101173471, DT.40144670
NIA Mouse Gene IndexU056751, U150803
Consensus CDS ProjectCCDS20882.2
International Mouse Knockout Project StatusNova2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036901 VEGA Gene Model | MGI Sequence Detail 36170 C57BL/6J ±  kb
transcript OTTMUST00000094799 VEGA | MGI Sequence Detail 5110 Not Applicable 
polypeptide OTTMUSP00000052832 VEGA | MGI Sequence Detail 556 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(241 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004087 K Homology domain
InterPro IPR004088 K Homology domain, type 1
Protein Ontology PR:000011340 RNA-binding protein Nova-2
References (Earliest) J:50542 Yang YY, et al., The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementia. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13254-9
(Latest) J:198011 Eom T, et al., NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure. Elife. 2013;2:e00178
All references(34)
Other
accession IDs
MGD-MRK-25623, MGI:2686270

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory