Ppard
Gene Detail

Symbol

Name
ID

Ppard
peroxisome proliferator activator receptor delta
MGI:101884

Synonyms

Nr1c2, NUC1, Peroxisome proliferator-activated receptor beta, Pparb, Pparb/d, PPAR-delta, PPARdelta/beta

Feature Type

protein coding gene

Genetic Map

Chromosome 17
14.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr17:28232754-28301469 bp, + strand From VEGA annotation of GRCm38   68716 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:4544  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: peroxisome proliferator activated receptor (PPAR)
Gene Tree: Ppard

Human
homologs

Human Homolog		PPARD, peroxisome proliferator-activated receptor delta
NCBI Gene ID		5467
neXtProt AC		NX_Q03181
Human Synonyms		FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB
Human Chr (Location)		6p21.2; chr6:35342558-35428191 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(80) : Gene trapped(66) Targeted(12) Transgenic(2)
 

Mice homozygous for a number of different targeted mutations show variable prenatal lethality and a range of phenotypes such as placental, brain, skin, hair follicle, adipose and lipid homeostasis abnormalities, growth retardation, reduced fertility, and increased incidence of tumors/induced tumors.

 
Phenotype Images(2)

Interactions

Ppard interacts with 231 markers (Mir9-1, Mir9-2, Mir9-3, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (74 annotations)

Process	adipose tissue development, anagen, ...
Component	nucleus
Function	DNA binding, drug binding, ...

External Resources: FuncBase

Expression

Literature Summary: (24 records)

Data Summary: Results (348)    Tissues (240)    Images (90)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	165
In situ reporter (knock in)	112
Northern blot	16
RT-PCR	55

cDNA source data(43)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(49) cDNA(43) Primer pair(4) Other(2)
Microarray probesets(5)

Other database
links

VEGA Gene Model	OTTMUSG00000023384 (Evidence)
Ensembl Gene Model	ENSMUSG00000002250 (Evidence)
Entrez Gene	19015 (Evidence)
UniGene	328914
DFCI	TC1582608
DoTS	DT.101352353, DT.40145035, DT.40156477, DT.101248218
Consensus CDS Project	CCDS28575.1
International Mouse Knockout Project Status	Ppard

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023384	VEGA Gene Model | MGI Sequence Detail	68716	C57BL/6J
transcript	OTTMUST00000056745	VEGA | MGI Sequence Detail	3218	Not Applicable
polypeptide	OTTMUSP00000027308	VEGA | MGI Sequence Detail	440	Not Applicable

All sequences(57) RefSeq(10) UniProt(4)

Polymorphisms

RFLP(3) : SNPs within 2kb(372 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR003074	Peroxisome proliferator-activated receptor
InterPro	IPR003075	Peroxisome proliferator-activated receptor, beta
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000013057	peroxisome proliferator-activated receptor delta

References

(Earliest) J:15412 Chen F, et al., Identification of two mPPAR related receptors and evidence for the existence of five subfamily members. Biochem Biophys Res Commun. 1993 Oct 29;196(2):671-7
(Latest) J:217209 Cottle DL, et al., Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis. Hum Mol Genet. 2015 Jan 15;24(2):436-49
All references(175)

Other
accession IDs

MGD-MRK-18710