About   Help   FAQ
Ppard Gene Detail
Summary
  • Symbol
    Ppard
  • Name
    peroxisome proliferator activator receptor delta
  • Synonyms
    Nr1c2, NUC1, Peroxisome proliferator-activated receptor beta, Pparb, Pparb/d, PPAR-delta, PPARdelta/beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:101884
    NCBI Gene: 19015
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:28232754-28301469 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      68716 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 14.64 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    PPARD, peroxisome proliferator activated receptor delta
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PPARD, peroxisome proliferator activated receptor delta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB
  • Links
    NCBI Gene ID: 5467
    neXtProt AC: NX_Q03181
    UniProt: Q03181

  • Chr Location
    6p21.31; chr6:35342558-35428191 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Ppard mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    110 phenotypes from 13 alleles in 12 genetic backgrounds
    5 phenotypes from multigenic genotypes
    2 images
    111 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a number of different targeted mutations show variable prenatal lethality and a range of phenotypes such as placental, brain, skin, hair follicle, adipose and lipid homeostasis abnormalities, growth retardation, reduced fertility, andincreased incidence of tumors/induced tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023384 VEGA Gene Model | MGI Sequence Detail 68716 C57BL/6J ±  kb
    transcript OTTMUST00000056745 VEGA | MGI Sequence Detail 3218 Not Applicable  
    polypeptide OTTMUSP00000027308 VEGA | MGI Sequence Detail 440 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      360 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000013057 peroxisome proliferator-activated receptor delta
    • InterPro Domains
      IPR001723 Nuclear hormone receptor
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR003074 Peroxisome proliferator-activated receptor
      IPR003075 Peroxisome proliferator-activated receptor, beta
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 45
      Primer pair 4
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-18710
    References
    more
    • Summaries
      All 231
      Developmental Gene Expression 26
      Diseases 2
      Gene Ontology 22
      Phenotypes 111
    • Earliest
      J:15412 Chen F, et al., Identification of two mPPAR related receptors and evidence for the existence of five subfamily members. Biochem Biophys Res Commun. 1993 Oct 29;196(2):671-7
    • Latest
      J:261041 Tan EHP, et al., ROS release by PPARbeta/delta-null fibroblasts reduces tumor load through epithelial antioxidant response. Oncogene. 2018 Apr;37(15):2067-2078

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory