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Ppard Gene Detail
Summary
  • Symbol
    Ppard
  • Name
    peroxisome proliferator activator receptor delta
  • Synonyms
    Nr1c2, NUC1, Peroxisome proliferator-activated receptor beta, Pparb, Pparb/d, PPAR-delta, PPARdelta/beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:101884
    NCBI Gene: 19015
Location & Maps
more
  • Sequence Map
    Chr17:28232754-28301469 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      68716 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 14.64 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    PPARD, peroxisome proliferator activated receptor delta
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PPARD, peroxisome proliferator activated receptor delta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB
  • Links
    NCBI Gene ID: 5467
    neXtProt AC: NX_Q03181

  • Chr Location
    6p21.2; chr6:35342558-35428191 (+)  GRCh38.p2
Human Diseases
more
  • Diseases
    1 with Ppard mouse models

Human Disease Mouse Models
       Diabetes Mellitus, Noninsulin-Dependent; NIDDM   OMIM: 125853 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    91 phenotypes from 12 alleles in 10 genetic backgrounds
    5 phenotypes from multigenic genotypes
    2 images
    105 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    82
  • Gene trapped
    66
  • Targeted
    12
  • Transgenic
    4
  • Incidental Mutations
    CvDC
Mice homozygous for a number of different targeted mutations show variable prenatal lethality and a range of phenotypes such as placental, brain, skin, hair follicle, adipose and lipid homeostasis abnormalities, growth retardation, reduced fertility, andincreased incidence of tumors/induced tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    79
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    348
  • Tissues
    240
  • cDNA Data
    43
  • Literature Summary
    24
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023384 VEGA Gene Model | MGI Sequence Detail 68716 C57BL/6J ±  kb
transcript OTTMUST00000056745 VEGA | MGI Sequence Detail 3218 Not Applicable  
polypeptide OTTMUSP00000027308 VEGA | MGI Sequence Detail 440 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    360 from dbSNP Build 142
  • RFLP
    3
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000013057 peroxisome proliferator-activated receptor delta
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR003074 Peroxisome proliferator-activated receptor
    IPR003075 Peroxisome proliferator-activated receptor, beta
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
less
  • All nucleic 49
    cDNA 43
    Primer pair 4
    Other 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-18710
References
more
  • Summaries
    All 186
    Developmental Gene Expression 24
    Diseases 1
    Gene Ontology 21
    Phenotypes 105
  • Earliest
    J:15412 Chen F, et al., Identification of two mPPAR related receptors and evidence for the existence of five subfamily members. Biochem Biophys Res Commun. 1993 Oct 29;196(2):671-7
  • Latest
    J:229664 Beyaz S, et al., High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. 2016 Mar 3;531(7592):53-8
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory