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Ppard
Gene Detail
 Symbol
Name
ID
Ppard
peroxisome proliferator activator receptor delta
MGI:101884
Synonyms Nr1c2, NUC1, Peroxisome proliferator-activated receptor beta, Pparb, Pparb/d, PPAR-delta, PPARdelta/beta
Feature Type protein coding gene
Genetic Map
Chromosome 17
14.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr17:28232754-28301469 bp, + strand
From VEGA annotation of GRCm38

  68716 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4544  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: peroxisome proliferator activated receptor (PPAR)
Gene Tree: Ppard

Human
homologs
Human Homolog PPARD, peroxisome proliferator-activated receptor delta
NCBI Gene ID 5467
neXtProt AC  NX_Q03181
Human Synonyms  FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB
Human Chr (Location)  6p21.2; chr6:35342558-35428191 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(78) : Gene trapped(66) Targeted(12)
 
Mice homozygous for a number of different targeted mutations show variable prenatal lethality and a range of phenotypes such as placental, brain, skin, hair follicle, adipose and lipid homeostasis abnormalities, growth retardation, reduced fertility, and increased incidence of tumors/induced tumors.
 
Phenotype Images(2)
Interactions
Ppard interacts with 231 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (71 annotations)
Process adipose tissue development, anagen, ...
Component nucleus
Function DNA binding, drug binding, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (348)    Tissues (233)    Images (90)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 165
In situ reporter (knock in) 112
Northern blot 16
RT-PCR 55
cDNA source data(43)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(49) cDNA(43) Primer pair(4) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000023384 (Evidence)
Ensembl Gene ModelENSMUSG00000002250 (Evidence)
Entrez Gene19015 (Evidence)
UniGene328914
DFCITC1582608
DoTSDT.101248218, DT.101352353, DT.40145035, DT.40156477
Consensus CDS ProjectCCDS28575.1
International Mouse Knockout Project StatusPpard
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023384 VEGA Gene Model | MGI Sequence Detail 68716 C57BL/6J ±  kb
transcript OTTMUST00000056745 VEGA | MGI Sequence Detail 3218 Not Applicable 
polypeptide OTTMUSP00000027308 VEGA | MGI Sequence Detail 440 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(6) UniProt(4)
Polymorphisms RFLP(3) : SNPs within 2kb(372 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR003074 Peroxisome proliferator-activated receptor
InterPro IPR003075 Peroxisome proliferator-activated receptor, beta
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000013057 peroxisome proliferator-activated receptor delta
References (Earliest) J:15412 Chen F, et al., Identification of two mPPAR related receptors and evidence for the existence of five subfamily members. Biochem Biophys Res Commun. 1993 Oct 29;196(2):671-7
(Latest) J:211686 Borland MG, et al., Modulation of aryl hydrocarbon receptor (AHR)-dependent signaling by peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) in keratinocytes. Carcinogenesis. 2014 Jul;35(7):1602-12
All references(170)
Other
accession IDs
MGD-MRK-18710

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory