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Mtf1
Gene Detail
 Symbol
Name
ID
Mtf1
metal response element binding transcription factor 1
MGI:101786
Synonyms metalloregulatory transcription factor, metal response element-binding transcription factor 1, MTF-1, Thyls
Feature Type protein coding gene
Genetic Map
Chromosome 4
57.91 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr4:124802104-124849379 bp, + strand
From VEGA annotation of GRCm38

  47276 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4347  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mtf1

Human
homologs
Human Homolog MTF1, metal-regulatory transcription factor 1
NCBI Gene ID 4520
neXtProt AC  NX_Q14872
Human Synonyms  MTF-1, ZRF
Human Chr (Location)  1p33; chr1:37809567-37859620 (-)  GRCh38
Alleles
and
phenotypes
All alleles(32) : Gene trapped(25) QTL(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation show impaired hepatocyte development followed by embryonic liver degeneration, generalized edema, and death at ~14 days of gestation. Mutant embryonic fibroblasts show increased susceptibility to the cytotoxiceffects of cadmium and hydrogen peroxide.
 
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process positive regulation of transcription, DNA-templated, positive regulation of transcription from RNA polymerase II promoter, ...
Component nucleus
Function core promoter binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (63)    Tissues (59)    Images (5)
Theiler Stages: 2, 3, 4, 5, 17, 19, 21, 23, 28
Assay TypeResults
RNA in situ 45
RT-PCR 15
RNase protection 3
cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(18) Genomic(1) cDNA(15) Primer pair(1) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000009170 (Evidence)
Ensembl Gene ModelENSMUSG00000028890 (Evidence)
Entrez Gene17764 (Evidence)
NIA Mouse Gene IndexU004790
Consensus CDS ProjectCCDS18627.1
International Mouse Knockout Project StatusMtf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009170 VEGA Gene Model | MGI Sequence Detail 47276 C57BL/6J ±  kb
transcript OTTMUST00000020735 VEGA | MGI Sequence Detail 7554 Not Applicable 
polypeptide OTTMUSP00000009511 VEGA | MGI Sequence Detail 675 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(8) UniProt(8)
Polymorphisms SNPs within 2kb(298 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000010717 metal regulatory transcription factor 1
References (Earliest) J:4714 Radtke F, et al., Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter. EMBO J. 1993 Apr;12(4):1355-62
(Latest) J:197394 Chowanadisai W, et al., Neurulation and neurite extension require the zinc transporter ZIP12 (slc39a12). Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9903-8
All references(64)
Other
accession IDs
MGD-MRK-18594, MGI:2151619

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory