Mtf1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mtf1
metal response element binding transcription factor 1
MGI:101786

25 phenotypes from 6 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mtf1^Thyls-BALB/c/Mtf1^Thyls-BALB/c involves: BALB/c * MSM	increased incidence of tumors by ionizing radiation induction	J:71358
Mtf1^Thyls-BALB/c/Mtf1^Thyls-BALB/c involves: BALB/c * MSM	increased T cell derived lymphoma incidence	J:71358
Mtf1^Thyls-BALB/c/Mtf1^Thyls-MSM involves: BALB/c * MSM	increased incidence of tumors by ionizing radiation induction	J:71358, J:85264
Mtf1^Thyls-BALB/c/Mtf1^Thyls-MSM involves: BALB/c * MSM	increased T cell derived lymphoma incidence	J:71358, J:85264
Mtf1^{tm1b(KOMP)Wtsi}/Mtf1⁺ C57BL/6N-Mtf1^{tm1b(KOMP)Wtsi}/J	abnormal retina morphology	J:211773
	decreased circulating glucose level	J:211773
	increased circulating aspartate transaminase level	J:211773
	increased circulating potassium level	J:211773
Mtf1^{tm1b(KOMP)Wtsi}/Mtf1^{tm1b(KOMP)Wtsi} C57BL/6N-Mtf1^{tm1b(KOMP)Wtsi}/J	abnormal craniofacial morphology	J:211773
	abnormal embryo size	J:211773
	abnormal forebrain morphology	J:211773
	anophthalmia	J:211773
	embryonic growth retardation	J:211773
	microphthalmia	J:211773
	prenatal lethality prior to heart atrial septation	J:211773
	preweaning lethality, complete penetrance	J:211773
Mtf1^tm1Wsc/Mtf1^tm1Wsc involves: 129 * C57BL/6	hepatic necrosis	J:48216
	increased cellular sensitivity to alkylating agents	J:48216
	lethality throughout fetal growth and development, complete penetrance	J:48216
Mtf1^tm1Wsc/Mtf1^tm1Wsc Not Specified	dilated liver sinusoidal space	J:91119
	hepatic necrosis	J:91119
	lethality throughout fetal growth and development, complete penetrance	J:91119
Mtf1^tm1Wsc/Mtf1^tm1Wsc Tg(Mx1-cre)1Cgn/0 Tg(UBC-Mtf1)1Wsc/0 involves: 129/Sv * C57BL/6 * CBA	abnormal xenobiotic pharmacokinetics	J:91119
	decreased leukocyte cell number	J:91119
	decreased lymphocyte cell number	J:91119
	increased physiological sensitivity to xenobiotic	J:91119
	increased susceptibility to xenobiotic induced morbidity/mortality	J:91119
Mtf1^tm1Wsc/Mtf1^tm1Wsc Tg(UBC-Mtf1)1Wsc/0 Not Specified	no abnormal phenotype detected	J:91119
Mtf1^tm2Wsc/Mtf1^tm2Wsc Tg(Mx1-cre)1Cgn/0 involves: 129 * C57BL/6 * CBA	abnormal liver physiology	J:102512

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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