Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd3tm1Pisc mutation
(0 available);
any
Ccnd3 mutation
(507 available)
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hematopoietic system
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• cytokine-driven expansion of DN-4 immature single-positive T lymphocytes is impaired
(J:88120)
• of pro- and pre-T cells
(J:192031)
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• at 5 weeks mice have severely hypoplastic thymuses
(J:88120)
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• fraction of double-negative cells in thymus is increased; however total number of double-negative thymocytes is unchanged compared to wild-type
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• 4-6 week-old mice have 7-fold fewer thymocytes than wild-type
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• fraction of double-positive cells in thymus is decreased; total number of double-positive thymocytes is reduced 12-fold
(J:88120)
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immune system
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• cytokine-driven expansion of DN-4 immature single-positive T lymphocytes is impaired
(J:88120)
• of pro- and pre-T cells
(J:192031)
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• at 5 weeks mice have severely hypoplastic thymuses
(J:88120)
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• fraction of double-negative cells in thymus is increased; however total number of double-negative thymocytes is unchanged compared to wild-type
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• 4-6 week-old mice have 7-fold fewer thymocytes than wild-type
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• fraction of double-positive cells in thymus is decreased; total number of double-positive thymocytes is reduced 12-fold
(J:88120)
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endocrine/exocrine glands
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• at 5 weeks mice have severely hypoplastic thymuses
(J:88120)
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cellular
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• cytokine-driven expansion of DN-4 immature single-positive T lymphocytes is impaired
(J:88120)
• of pro- and pre-T cells
(J:192031)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd3tm1Pisc mutation
(0 available);
any
Ccnd3 mutation
(507 available)
Rb1tm2Brn mutation
(3 available);
any
Rb1 mutation
(106 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
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immune system
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• of pre-T cells as in Ccnd3tm1Pisc homozygotes
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• not as severe as in pIpC-treated mice as in Ccnd3tm1Pisc homozygotes
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• as in Ccnd3tm1Pisc homozygotes
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hematopoietic system
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• of pre-T cells as in Ccnd3tm1Pisc homozygotes
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• not as severe as in pIpC-treated mice as in Ccnd3tm1Pisc homozygotes
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• as in Ccnd3tm1Pisc homozygotes
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endocrine/exocrine glands
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• not as severe as in pIpC-treated mice as in Ccnd3tm1Pisc homozygotes
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cellular
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• of pre-T cells as in Ccnd3tm1Pisc homozygotes
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immune system
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• mice exhibit normal numbers of thymocytes, double negative cells, double positive cells and pre-T cell proliferation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1tm1Dsn mutation
(0 available);
any
Ccnd1 mutation
(21 available)
Ccnd2tm1Wbg mutation
(0 available);
any
Ccnd2 mutation
(24 available)
Ccnd3tm1Pisc mutation
(0 available);
any
Ccnd3 mutation
(507 available)
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mortality/aging
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• by E15.5 embryos appear pale
• by E16.5 no viable embryos are observed
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cardiovascular system
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• thinned walls of embryonic heart ventricles, mainly in compact zone
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hematopoietic system
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• total number of fetal liver cells reduced at E14.5
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• common myeloid progenitors cells substantially reduced
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• common lymphoid progenitors cells reduced by 46 fold
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• E14.5 embryos exhibit 8-fold decrease in peripheral blood erythrocytes
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• impaired ability of hematopoietic stem cells to proliferate
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• hematopoietic stem cells reduced 5.7 fold in E14.5 liver
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homeostasis/metabolism
immune system
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• common lymphoid progenitors cells reduced by 46 fold
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd3tm1Pisc mutation
(0 available);
any
Ccnd3 mutation
(507 available)
Rag2tm1Fwa mutation
(48 available);
any
Rag2 mutation
(117 available)
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hematopoietic system
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• after injection with anti-CD3epsilon antibodies number of thymocytes increases 60-fold compared to Ccnd3-competent, Rag2 null animals
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immune system
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• after injection with anti-CD3epsilon antibodies number of thymocytes increases 60-fold compared to Ccnd3-competent, Rag2 null animals
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cellular
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• after injection with anti-CD3epsilon antibodies number of thymocytes increases 60-fold compared to Ccnd3-competent, Rag2 null animals
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd3tm1Pisc mutation
(0 available);
any
Ccnd3 mutation
(507 available)
Trp53tm1Tyj mutation
(12 available);
any
Trp53 mutation
(232 available)
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mortality/aging
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• animals die by about 26 weeks
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neoplasm
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• mice develop T cell malignancies with similar kinetics as Trp53-null mice
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endocrine/exocrine glands
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• mice develop T cell malignancies with similar kinetics as Trp53-null mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd3tm1Pisc mutation
(0 available);
any
Ccnd3 mutation
(507 available)
Cdkn1btm1Mlf mutation
(2 available);
any
Cdkn1b mutation
(25 available)
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immune system
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• of pre-T cells as in Ccnd3tm1Pisc homozygotes
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• not as severe as in Ccnd3tm1Pisc homozygotes
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• as in Ccnd3tm1Pisc homozygotes
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hematopoietic system
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• of pre-T cells as in Ccnd3tm1Pisc homozygotes
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• not as severe as in Ccnd3tm1Pisc homozygotes
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• as in Ccnd3tm1Pisc homozygotes
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• bone marrow progenitor cells transfected with a retrovirus encoding the constitutively active intracellular domain of Notch1 slightly delays development of T cell acute lymphoblastic leukemia in recipient irradiated wild-type mice from the
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endocrine/exocrine glands
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• not as severe as in Ccnd3tm1Pisc homozygotes
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cellular
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• of pre-T cells as in Ccnd3tm1Pisc homozygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd3tm1Pisc mutation
(0 available);
any
Ccnd3 mutation
(507 available)
Tg(Lck)4220Rmp mutation
(0 available)
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mortality/aging
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• mice develop T cell tumors and die starting at 13-15 weeks of age with 100% mortality observed by 22 weeks
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neoplasm
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• mice develop T cell malignancies starting at 13-15 weeks
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• tumor formation is delayed 6-8 weeks compared to Ccnd3-sufficient, Tg(Lck)4220Rmp-expressing animals
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endocrine/exocrine glands
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• mice develop T cell malignancies starting at 13-15 weeks
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1tm1Wbg mutation
(2 available);
any
Ccnd1 mutation
(21 available)
Ccnd3tm1Pisc mutation
(0 available);
any
Ccnd3 mutation
(507 available)
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mortality/aging
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• while mice were born near the expected frequency, most died within the first day demonstrating impaired suckling
• some mice survived the perinatal period
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behavior/neurological
growth/size/body
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• mice that survived the perinatal period did not thrive and were much smaller than wild-type littermates in spite of a calorie-rich diet
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respiratory system
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• suggestions of acute asphyxiation caused by meconium aspiration syndrome
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vision/eye
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd2tm1Wbg mutation
(0 available);
any
Ccnd2 mutation
(24 available)
Ccnd3tm1Pisc mutation
(0 available);
any
Ccnd3 mutation
(507 available)
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mortality/aging
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• fetuses died during late gestation with none surviving past E18.5
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hematopoietic system
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• ~4 fold decrease in the number of peripheral red blood cells relative to wild-type
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liver/biliary system
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• abnormal fetal liver morphogenesis
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Analysis Tools