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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Agtr2tm1Tin
targeted mutation 1, Tadashi Inagami
MGI:2178475
Summary 13 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Agtr2tm1Tin/Agtr2tm1Tin involves: 129P2/OlaHsd MGI:4453876
hm2
Agtr2tm1Tin/Agtr2tm1Tin involves: 129P2/OlaHsd * C57BL/6 MGI:4453872
cn3
Agtr2tm1Tin/Y
Efemp2tm1.1Hiya/Efemp2tm1.2Hiya
Tg(Tagln-cre)1Her/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL MGI:5585151
cx4
Agtr1atm1Unc/Agtr1atm1Unc
Agtr1btm1Cof/Agtr1btm1Cof
Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6 MGI:4454284
cx5
Agtr1atm1Unc/Agtr1atm1Unc
Agtr1btm1Cof/Agtr1btm1Cof
Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6 MGI:4454285
cx6
Agtr1btm1Cof/Agtr1btm1Cof
Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6 MGI:4454287
cx7
Agtr1btm1Cof/Agtr1btm1Cof
Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6 MGI:4454288
cx8
Agtr1atm1Unc/Agtr1atm1Unc
Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6 MGI:4454289
cx9
Agtr1atm1Unc/Agtr1atm1Unc
Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6 MGI:4454290
ot10
Agtr2tm1Tin/Y B6.129P2-Agtr2tm1Tin MGI:4453877
ot11
Agtr2tm1Tin/Y involves: 129P2/OlaHsd MGI:4453871
ot12
Agtr2tm1Tin/Y involves: 129P2/OlaHsd * C57BL/6 MGI:2655634
ot13
Agtr2tm1Tin/Y SWR.129P2-Agtr2tm1Tin MGI:4454268


Genotype
MGI:4453876
hm1
Allelic
Composition
Agtr2tm1Tin/Agtr2tm1Tin
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr2tm1Tin mutation (0 available); any Agtr2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• cortical blood flow is lower than in wild-type mice
• at high renal perfusion pressure, renal blood flow is lower than in similarly treated wild-type mice
• as renal perfusion pressure increases, mice fail to exhibit an increase in medullary blood flow unlike in similarly treated wild-type mice
• however, glomerular filtration rate is normal
• renal vascular resistance is higher than in wild-type mice
• at 113 or 118 mm Hg equivalent renal perfusion pressure, diuresis and natriuresis are 3 times lower than in wild-type mice
• as renal perfusion pressure increases, fractional sodium and water excretion curves are shifted rightward compared to in wild-type mice
• at 113 or 118 mm Hg equivalent renal perfusion pressure, natriuresis is 3 times lower than in wild-type mice

cardiovascular system
• cortical blood flow is lower than in wild-type mice
• at high renal perfusion pressure, renal blood flow is lower than in similarly treated wild-type mice
• as renal perfusion pressure increases, mice fail to exhibit an increase in medullary blood flow unlike in similarly treated wild-type mice
• however, glomerular filtration rate is normal
• renal vascular resistance is higher than in wild-type mice

homeostasis/metabolism
• at 113 or 118 mm Hg equivalent renal perfusion pressure, diuresis and natriuresis are 3 times lower than in wild-type mice
• as renal perfusion pressure increases, fractional sodium and water excretion curves are shifted rightward compared to in wild-type mice
• at 113 or 118 mm Hg equivalent renal perfusion pressure, natriuresis is 3 times lower than in wild-type mice




Genotype
MGI:4453872
hm2
Allelic
Composition
Agtr2tm1Tin/Agtr2tm1Tin
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr2tm1Tin mutation (0 available); any Agtr2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• 23 males and 5 females out of 112 males and 91 females exhibit congenital anomalies of the kidney and urinary tract unlike wild-type mice with greater frequency in male mice and frequent unilaterality
• 23% of affected mice exhibit ureteripelvic junction, 20% hydronephrotic kidney and hydroureter, 13% hypoplastic kidney, 29% multicystic dysplastic kidney, 10% megaureter, and 6% aplastic kidney unlike wild-type mice
• at E18.5, an affected mouse exhibited vesicoureteral junction stenosis or ureterovesical reflux unlike wild-type mice
• in some affected mice
• premature tubules and glomeruli surrounded by undifferentiated mesenchymal cells in some affected mice
• 20% of affected mice display hydronephrosis and hydroureter, associated with thinning of the renal parenchyma
• 13% of affected mice show renal hypoplasia
• 6% of affected mice show no trace of renal tissue despite the presence of the ureter
• some affected mice exhibit abnormal rotation or ascent of the kidneys compared with wild-type mice
• 29% of affected mice display multicystic dysplastic kidney
• at E16.5, some affected mice exhibit an increase in the number of undifferentiated mesenchymal cells surrounding the middle portion of the ureter and a lower frequency of apoptotic cells around the ureter compared with wild-type mice
• dilated and tortuous in some affected mice
• double ureter in an affected mouse at E17.5
• 20% of affected mice display hydronephrosis and hydroureter, associated with thinning of the renal parenchyma
• 10% of affected mice display a megaureter without hydronephrosis, apparent obstruction or atresia of the ureter
• some affected mice exhibit ureteropelvic junction atresia unlike wild-type mice
• 23% of affected mice exhibit ureteropelvic junction stenosis unlike wild-type mice
• ureterovesical junction stenosis is accompanied by both hydronephrosis and hydroureter
• the minimum pressure required to induce backflux of dye from the bladder to the ureter in affected mice is lower than in wild-type mice
• at E16.5, some affected mice exhibit a lower frequency of apoptotic cells around the ureter compared with wild-type mice
• undifferentiated mesenchymal cells from affected mice exhibit reduced Angiotensin 2-induced apoptosis compared with similarly treated wild-type cells
• VUR is accompanied by both hydronephrosis and hydroureter

nervous system
• adrenal epinepherine levels are increased compared to in wild-type mice
• adrenal norepinepherine levels are increased compared to in wild-type mice

homeostasis/metabolism
• adrenal epinepherine levels are increased compared to in wild-type mice
• adrenal norepinepherine levels are increased compared to in wild-type mice
• adrenal aldosterone content is reduced by 70% compared to that in wild-type mice
• however, plasma aldosterone levels are normal
• adrenal corticosterone levels are slightly reduced compared to in wild-type mice
• Et-1-treated mice exhibit a positive chronotropic effect unlike wild-type mice
• mice exposed to repeated treatments with cerulein to induce pancreatitis exhibit a greater decrease in pancreas weight, more severe alterations in pancreas morphology with replacement of acinar cell architecture with fibrous stromal tubular structures, and increased fibrosis compared to in similarly treated wild-type mice

cardiovascular system
• Et-1-treated mice exhibit a positive chronotropic effect unlike wild-type mice

endocrine/exocrine glands
• mice exposed to repeated treatments with cerulein to induce pancreatitis exhibit a more severe alterations in pancreas morphology than similarly treated wild-type mice with replacement of acinar cell architecture with fibrous stromal tubular structures
• mice exposed to repeated treatments with cerulein to induce pancreatitis exhibit replacement of acinar cell architecture with fibrous stromal tubular structures unlike similarly treated wild-type mice
• mice exposed to repeated treatments with cerulein to induce pancreatitis exhibit a greater decrease in pancreas weight than similarly treated wild-type mice
• following repetitive cerulein treatment

digestive/alimentary system
• mice exposed to repeated treatments with cerulein to induce pancreatitis exhibit replacement of acinar cell architecture with fibrous stromal tubular structures unlike similarly treated wild-type mice




Genotype
MGI:5585151
cn3
Allelic
Composition
Agtr2tm1Tin/Y
Efemp2tm1.1Hiya/Efemp2tm1.2Hiya
Tg(Tagln-cre)1Her/0
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr2tm1Tin mutation (0 available); any Agtr2 mutation (5 available)
Efemp2tm1.1Hiya mutation (0 available); any Efemp2 mutation (3 available)
Efemp2tm1.2Hiya mutation (0 available); any Efemp2 mutation (3 available)
Tg(Tagln-cre)1Her mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• hyperproliferation and disarray of aorta smooth muscle cells at 3 months of age
• the medium of the aortic wall is thicker than in single Agtr2 mutants, with hyperproliferation and disarray of smooth muscle cells at 3 months of age
• mice develop aneurysms
• treatment with losartan completely prevents aneurysms

muscle
• hyperproliferation and disarray of aorta smooth muscle cells at 3 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
aortic aneurysm DOID:3627 J:213282




Genotype
MGI:4454284
cx4
Allelic
Composition
Agtr1atm1Unc/Agtr1atm1Unc
Agtr1btm1Cof/Agtr1btm1Cof
Agtr2tm1Tin/Agtr2tm1Tin
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (15 available)
Agtr1btm1Cof mutation (0 available); any Agtr1b mutation (10 available)
Agtr2tm1Tin mutation (0 available); any Agtr2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice are present at weaning

cardiovascular system
• compared with wild-type mice and Agtr1atm1Unc homozygotes
• compared with wild-type mice and Agtr1atm1Unc homozygotes
• Ang II-treated mice exhibit an almost completely blunted increase in mean arterial blood pressure (MAP) and heart rate with a shortened time to peak MAP and an increased time to normalization of MAP compared with similarly treated wild-type mice
• PE-treated mice exhibit a smaller increase in MAP compared with similarly treated wild-type mice
• compared with wild-type mice and Agtr1atm1Unc homozygotes

homeostasis/metabolism
• angiotensin II (Ang II)-treated mice exhibit an almost completely blunted increase in mean arterial blood pressure (MAP) and heart rate with a shortened time to peak MAP and an increased time to normalization of MAP compared with similarly treated wild-type mice
• endothelin 1 (Et-1)-treated mice exhibit a positive chronotropic effect unlike wild-type mice
• phenylephrine (PE)-treated mice exhibit a smaller increase in MAP and fail to exhibit any chronotropic response compared with similarly treated wild-type mice

renal/urinary system
• in some mice
• compared with wild type mice and Agtr1atm1Unc Agtr1btm1Cof double homozygotes

growth/size/body
• compared with wild-type mice that is not as severe as in Agtr1atm1Unc Agtr1btm1Cof double homozygotes




Genotype
MGI:4454285
cx5
Allelic
Composition
Agtr1atm1Unc/Agtr1atm1Unc
Agtr1btm1Cof/Agtr1btm1Cof
Agtr2tm1Tin/Y
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (15 available)
Agtr1btm1Cof mutation (0 available); any Agtr1b mutation (10 available)
Agtr2tm1Tin mutation (0 available); any Agtr2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice are present at weaning

cardiovascular system
• compared with wild-type mice and Agtr1atm1Unc homozygotes
• compared with wild-type mice and Agtr1atm1Unc homozygotes
• Ang II-treated mice exhibit an almost completely blunted increase in mean arterial blood pressure (MAP) and heart rate with a shortened time to peak MAP and an increased time to normalization of MAP compared with similarly treated wild-type mice
• PE-treated mice exhibit a smaller increase in MAP compared with similarly treated wild-type mice
• compared with wild-type mice and Agtr1atm1Unc homozygotes

homeostasis/metabolism
• angiotensin II (Ang II)-treated mice exhibit an almost completely blunted increase in mean arterial blood pressure (MAP) and heart rate with a shortened time to peak MAP and an increased time to normalization of MAP compared with similarly treated wild-type mice
• endothelin 1 (Et-1)-treated mice exhibit a positive chronotropic effect unlike wild-type mice
• phenylephrine (PE)-treated mice exhibit a smaller increase in MAP and fail to exhibit any chronotropic response compared with similarly treated wild-type mice

renal/urinary system
• in some mice
• compared with wild type mice and Agtr1atm1Unc Agtr1btm1Cof double homozygotes

growth/size/body
• compared with wild-type mice that is not as severe as in Agtr1atm1Unc Agtr1btm1Cof double homozygotes




Genotype
MGI:4454287
cx6
Allelic
Composition
Agtr1btm1Cof/Agtr1btm1Cof
Agtr2tm1Tin/Y
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1btm1Cof mutation (0 available); any Agtr1b mutation (10 available)
Agtr2tm1Tin mutation (0 available); any Agtr2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• mice exhibit hyperemic capillary loops unlike wild-type mice
• however, glomeruli are well perfused with distinct basal membranes

cardiovascular system

growth/size/body




Genotype
MGI:4454288
cx7
Allelic
Composition
Agtr1btm1Cof/Agtr1btm1Cof
Agtr2tm1Tin/Agtr2tm1Tin
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1btm1Cof mutation (0 available); any Agtr1b mutation (10 available)
Agtr2tm1Tin mutation (0 available); any Agtr2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• mice exhibit hyperemic capillary loops unlike wild-type mice
• however, glomeruli are well perfused with distinct basal membranes

cardiovascular system

growth/size/body




Genotype
MGI:4454289
cx8
Allelic
Composition
Agtr1atm1Unc/Agtr1atm1Unc
Agtr2tm1Tin/Y
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (15 available)
Agtr2tm1Tin mutation (0 available); any Agtr2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• Ang II-treated mice exhibit less of an increase in mean arterial blood pressure and heart rate compared with similarly treated wild-type mice
• Ang II-treated mice exhibit less of an increase in mean arterial blood pressure and heart rate compared with similarly treated wild-type mice

homeostasis/metabolism
• serum levels of Ang II are increased compared to in wild-type mice
• angeotensin II (Ang II)-treated mice exhibit less of an increase in mean arterial blood pressure and heart rate compared with similarly treated wild-type mice

renal/urinary system
• mice exhibit cystic dilated Bowman's space unlike wild-type mice
• mice exhibit multifocal glomeruli atrophy unlike wild-type mice




Genotype
MGI:4454290
cx9
Allelic
Composition
Agtr1atm1Unc/Agtr1atm1Unc
Agtr2tm1Tin/Agtr2tm1Tin
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (15 available)
Agtr2tm1Tin mutation (0 available); any Agtr2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• Ang II-treated mice exhibit less of an increase in mean arterial blood pressure and heart rate compared with similarly treated wild-type mice
• Ang II-treated mice exhibit less of an increase in mean arterial blood pressure and heart rate compared with similarly treated wild-type mice

homeostasis/metabolism
• serum levels of Ang II are increased compared to in wild-type mice
• angeotensin II (Ang II)-treated mice exhibit less of an increase in mean arterial blood pressure and heart rate compared with similarly treated wild-type mice

renal/urinary system
• mice exhibit cystic dilated Bowman's space unlike wild-type mice
• mice exhibit multifocal glomeruli atrophy unlike wild-type mice




Genotype
MGI:4453877
ot10
Allelic
Composition
Agtr2tm1Tin/Y
Genetic
Background
B6.129P2-Agtr2tm1Tin
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr2tm1Tin mutation (0 available); any Agtr2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• one week after myocardial infarction, more mice exhibit death due to cardiac rupture compared with similarly treated wild-type mice
• however, 6 week survival following myocardial infarction is normal

cardiovascular system
• following aorta banding, cardiomyocyte cross-sectional area does not increase as much as in similarly treated wild-type mice
• the intraventricular septum is thinner than in wild-type mice
• after myocardial infarction, the increase in left ventricular internal diameter at end diastole and end systole is less than similarly treated wild-type mice
• prior to and after myocardial infarction
• the left ventricular posterior wall is thinner than in wild-type mice
• following aorta banding, mice exhibit less left ventricular and interstitial fibrosis compared with similarly treated wild-type mice (J:63751)
• after myocardial infarction cardiac fibrosis are reduced compared to in similarly treated wild-type mice (J:146723)
• following aorta banding, mice fail to exhibit as much left ventricle hypertrophy, cardiomyocyte cross-sectional area increase, and left ventricular and interstitial fibrosis as in similarly treated wild-type mice
• however, left ventricular function following aorta banding is the same as in similarly treated wild-type mice
• one week after myocardial infarction, more mice exhibit death due to cardiac rupture compared with similarly treated wild-type mice
• after myocardial infarction, the increase in left ventricular internal diameter at end diastole and end systole is less than similarly treated wild-type mice
• after myocardial infarction, percent infarct area and cardiac fibrosis are reduced compared to in similarly treated wild-type mice
• however, 6 week survival following myocardial infarction is normal

homeostasis/metabolism
• following aorta banding, mice fail to exhibit as much left ventricle hypertrophy, cardiomyocyte cross-sectional area increase, and left ventricular and interstitial fibrosis as in similarly treated wild-type mice
• however, left ventricular function following aorta banding is the same as in similarly treated wild-type mice
• one week after myocardial infarction, more mice exhibit death due to cardiac rupture compared with similarly treated wild-type mice
• after myocardial infarction, the increase in left ventricular internal diameter at end diastole and end systole is less than similarly treated wild-type mice
• after myocardial infarction, percent infarct area and cardiac fibrosis are reduced compared to in similarly treated wild-type mice
• however, 6 week survival following myocardial infarction is normal

muscle
• following aorta banding, cardiomyocyte cross-sectional area does not increase as much as in similarly treated wild-type mice




Genotype
MGI:4453871
ot11
Allelic
Composition
Agtr2tm1Tin/Y
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr2tm1Tin mutation (0 available); any Agtr2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• unlike wild-type mice fed a high fat diet, similarly treated wild-type mice fail to exhibit hyperleptinemia
• when fed a high fat diet
• when fed standard chow or a high fat diet
• during the light phase when fed standard chow
• during the dark phase when fed a high fat diet
• unlike in wild-type mice, glucose oxidation and glucose conversion into lipids is not stimulated by Ang II with or without angiotensin II receptor, type 1a, antagonists
• when fed a high fat diet, glucose clearance is increased compared to in similarly treated wild-type mice
• unlike wild-type mice fed a high fat diet, mice fail to exhibit an increase in plasma insulin levels
• when fed standard chow or a high fat diet
• lipid oxidation is increased 30% compared to in wild-type mice
• when fed a high fat diet, mice exhibit increased lipid oxidation compared to in similarly treated wild-type mice
• when fed a high fat diet, mice fail to exhibit as much of an increase in muscle triglyceride content as in similarly treated wild-type mice
• at 113 or 118 mm Hg equivalent renal perfusion pressure, diuresis and natriuresis are 3 times lower than in wild-type mice
• as renal perfusion pressure increases, fractional sodium and water excretion curves are shifted rightward compared to in wild-type mice
• at 113 or 118 mm Hg equivalent renal perfusion pressure, natriuresis is 3 times lower than in wild-type mice
• unlike in wild-type mice, glucose oxidation and glucose conversion into lipids is not stimulated by Ang II with or without angiotensin II receptor, type 1a, antagonists
• L-NAME-treated mice exhibit a greater increase in blood pressure and reduced heart rate variability compared with similarly treated wild-type mice

nervous system
• the number of cells in the medial habenula is increased compared to in wild-type mice
• however, the size of the neuronal somata is normal
• the number of cells in the ventromedial, ventroposterior, and anterodorsal nuclei and zona incerta is increased compared to in wild-type mice
• however, the size of the neuronal somata is normal
• the number of cells in the basolateral complex, lateral complex, basolateral nucleus, medial nucleus, central nucleus, and basomedial nucleus of the amygdala is increased compared to in wild-type mice
• however, the size of the neuronal somata is normal
• the number of cells in the CA1 region is increased than in wild-type mice
• however, the size of the neuronal somata is normal
• the number of cells in the CA2 region is increased than in wild-type mice
• however, the size of the neuronal somata is normal
• the number of cells in the CA3 region is increased than in wild-type mice
• however, the size of the neuronal somata is normal
• the density and number of cells in the piriform cortex is increased than in wild-type mice
• however, the size of the neuronal somata is normal
• systolic blood pressure variability in the low frequency band is reduced compared to in wild-type mice
• baroreflex sensitivity calculated as the mean value of the transfer function between systolic blood pressure and RR intervals in the low frequency band or with the sequence technique for upslopes of systolic blood pressure is increased compared to in wild-type mice
• mice exhibit higher baroreflex sensitivity compared with wild-type mice
• however, hypertension-producing treatments do not affect baroreflex sensitivity

renal/urinary system
• cortical blood flow is lower than in wild-type mice
• at high renal perfusion pressure, renal blood flow is lower than in similarly treated wild-type mice
• as renal perfusion pressure increases, mice fail to exhibit an increase in medullary blood flow unlike in similarly treated wild-type mice
• however, glomerular filtration rate is normal
• renal vascular resistance is higher than in wild-type mice
• following unilateral ureter obstruction, tubulointerstitial apoptosis is decreased compared to in similarly treated wild-type mice
• at 113 or 118 mm Hg equivalent renal perfusion pressure, diuresis and natriuresis are 3 times lower than in wild-type mice
• as renal perfusion pressure increases, fractional sodium and water excretion curves are shifted rightward compared to in wild-type mice
• at 113 or 118 mm Hg equivalent renal perfusion pressure, natriuresis is 3 times lower than in wild-type mice
• following unilateral ureter obstruction, mice exhibit increased fibrosis, widening of interstitial space, increased in cellularity and loss of close contact between peritubular capillaries and tubules with increased intervening trichrome+ materials compared with similarly treated wild-type mice
• however, unobstructed kidneys are normal
• following unilateral ureter obstruction, interstitial collagen is increased compared to in similarly treated wild-type mice

cardiovascular system
• following transplantation of LL2 carcinoma cells, mice exhibit a decrease in angiogenesis compared with similarly treated wild-type mice
• following transplantation of LL2 carcinoma cells, mice treated with the ACE inhibitor enalapril exhibit a decrease in angiogenesis compared with wild-type mice transplantated with LL2 carcinoma cells
• cortical blood flow is lower than in wild-type mice
• at high renal perfusion pressure, renal blood flow is lower than in similarly treated wild-type mice
• as renal perfusion pressure increases, mice fail to exhibit an increase in medullary blood flow unlike in similarly treated wild-type mice
• however, glomerular filtration rate is normal
• renal vascular resistance is higher than in wild-type mice
• unlike wild-type mice fed a high fat diet, similarly treated wild-type mice fail to exhibit an increase in systolic blood pressure
• L-NAME-treated mice exhibit a greater increase in blood pressure compared with similarly treated wild-type mice
• mice on a DOCA-salt regime exhibit a greater increase in blood pressure compared with similarly treated wild-type mice
• in L-NAME and DOCA-salt treated mice

adipose tissue
• 2-fold lower in epididymal adipose tissue compared to in wild-type mice
• 2-fold lower in epididymal adipose tissue compared to in wild-type mice
• unlike wild-type mice fed a high fat diet, similarly treated wild-type mice fail to exhibit an increase in epididymal adipose tissue

behavior/neurological
• when fed a high fat diet

growth/size/body
• when fed a high fat diet
• when fed standard chow or a high fat diet

cellular
• following unilateral ureter obstruction, tubulointerstitial apoptosis is decreased compared to in similarly treated wild-type mice




Genotype
MGI:2655634
ot12
Allelic
Composition
Agtr2tm1Tin/Y
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr2tm1Tin mutation (0 available); any Agtr2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Enhanced bone mass in Agtr2tm1Tin/Y mice

nervous system
• adrenal epinepherine levels are increased compared to in wild-type mice
• adrenal norepinepherine levels are increased compared to in wild-type mice

renal/urinary system
• 23 males and 5 females out of 112 males and 91 females exhibit congenital anomalies of the kidney and urinary tract unlike wild-type mice with greater frequency in male mice and frequent unilaterality
• 23% of affected mice exhibit ureteropelvic junction stenosis, 20% hydronephrotic kidney and hydroureter, 13% hypoplastic kidney, 29% multicystic dysplastic kidney, 10% megaureter, and 6% aplastic kidney unlike wild-type mice
• some affected mice exhibit ureteropelvic junction atresia unlike wild-type mice
• at E18.5, an affected mouse exhibited vesicoureteral junction stenosis or ureterovesical reflux unlike wild-type mice
• in some affected mice
• premature tubules and glomeruli surrounded by undifferentiated mesenchymal cells in some affected mice
• 20% of affected mice display hydronephrosis and hydroureter, associated with thinning of the renal parenchyma
• 13% of affected mice show renal hypoplasia
• 6% of affected mice show no trace of renal tissue despite the presence of the ureter
• some affected mice exhibit abnormal rotation or ascent of the kidneys compared with wild-type mice
• 29% of affected mice display multicystic dysplastic kidney
• dilated and tortuous in some affected mice
• at E16.5, some affected mice exhibit an increase in the number of undifferentiated mesenchymal cells surrounding the middle portion of the ureter and a lower frequency of apoptotic cells around the ureter compared with wild-type mice
• double ureter in an affected mouse at E17.5
• 20% of affected mice display hydronephrosis and hydroureter, associated with thinning of the renal parenchyma
• 10% of affected mice display a megaureter without hydronephrosis, apparent obstruction or atresia of the ureter
• some affected mice exhibit ureteropelvic junction atresia unlike wild-type mice
• 23% of affected mice exhibit ureteropelvic junction stenosis unlike wild-type mice
• ureterovesical junction stenosis is accompanied by both hydronephrosis and hydroureter
• the minimum pressure required to induce backflux of dye from the bladder to the ureter in affected mice is lower than in wild-type mice
• at E16.5, some affected mice exhibit a lower frequency of apoptotic cells around the ureter compared with wild-type mice
• undifferentiated mesenchymal cells from affected mice exhibit reduced Angiotensin 2-induced apoptosis compared with similarly treated wild-type cells

homeostasis/metabolism
• hemizygous males show a significant decrease in body temperature relative to wild-type males (37.4 0.1 C vs 37.9 0.1 C, respectively)
• adrenal epinepherine levels are increased compared to in wild-type mice
• adrenal norepinepherine levels are increased compared to in wild-type mice
• adrenal aldosterone content is reduced by 70% compared to that in wild-type mice
• however, plasma aldosterone levels are normal
• adrenal corticosterone levels are slightly reduced compared to in wild-type mice
• Et-1-treated mice exhibit a positive chronotropic effect unlike wild-type mice
• mice exposed to repeated treatments with cerulein to induce pancreatitis exhibit a greater decrease in pancreas weight, more severe alterations in pancreas morphology with replacement of acinar cell architecture with fibrous stromal tubular structures, and increased fibrosis compared to in similarly treated wild-type mice

cardiovascular system
• Et-1-treated mice exhibit a positive chronotropic effect unlike wild-type mice
• hemizygous males are viable and fertile with no histological abnormalities in the brain, heart, lung, kidney and adrenal gland; however, they exhibit a significantly higher baseline blood pressure relative to wild-type mice
• in addition, hemizygous males show increased vasopressor responsiveness to exogenous angiotensin II after endogenous angiotensin II production has been inhibited by captopril
• losartan (an AT1 receptor-specific antagonist) reduces BP to the same extent as captopril treatment in both hemizygous and wild-type males
• male hemizygous have a generally higher heart rate than wild-type mice at baseline and after captopril, angiotensin II or losartan treatment but the difference is not statistically significant
• in contrast to Agtr2tm1Gsb/Y mice, these mice show increased baseline blood pressure
• hemizygous males exhibit a significantly higher baseline diastolic blood pressure (DBP) relative to wild-type mice; this difference in basal DBP persists after captopril treatment
• in addition, hemizygous males display a significantly higher increase in DBP than wild-type mice in response to various doses of exogenous angiotensin II (3, 10, and 30 ng/min/kg for 5 min each) after endogenous angiotensin II production has been inhibited by captopril
• the difference in basal DBP persists even after losartan treatment, indicating that this effect is AT1-independent
• hemizygous males exhibit a significantly higher baseline systolic blood pressure (SBP) relative to wild-type mice; captopril treatment reduces SBP down to comparable values in hemizygous and wild-type males
• in addition, hemizygous males display a significantly higher increase in SBP than wild-type mice in response to various doses of exogenous angiotensin II (3, 10, and 30 ng/min/kg for 5 min each) after endogenous angiotensin II production has been inhibited by captopril

behavior/neurological
• hemizygous males show normal awareness, posture, motor coordination, muscle tone and reflexes in a multiparametric check list
• however, when placed in one corner of an open field divided into identical squares, mutant males show significantly reduced ambulation, with no significant differences in starting latency or rearing activity
• based on a multiparameter checklist
• hemizygous males show a small reduction in the startle response relative to wild-type mice
• hemizygous males show increased hypoalgesia relative to wild-type mice

skeleton
• the ratio of bone volume to tissue volume is increased compared to in wild-type mice
• separation in the trabecular bone and trabecular space are decreased compared to in wild-type mice
• trabecular number is increased compared to in wild-type mice
• trabecular bone exhibits a crowded pattern unlike in wild-type mice

endocrine/exocrine glands
• mice exposed to repeated treatments with cerulein to induce pancreatitis exhibit a more severe alterations in pancreas morphology than similarly treated wild-type mice with replacement of acinar cell architecture with fibrous stromal tubular structures
• mice exposed to repeated treatments with cerulein to induce pancreatitis exhibit replacement of acinar cell architecture with fibrous stromal tubular structures unlike similarly treated wild-type mice
• mice exposed to repeated treatments with cerulein to induce pancreatitis exhibit a greater decrease in pancreas weight than similarly treated wild-type mice
• following repetitive cerulein treatment

digestive/alimentary system
• mice exposed to repeated treatments with cerulein to induce pancreatitis exhibit replacement of acinar cell architecture with fibrous stromal tubular structures unlike similarly treated wild-type mice

integument
• hemizygous males show increased hypoalgesia relative to wild-type mice




Genotype
MGI:4454268
ot13
Allelic
Composition
Agtr2tm1Tin/Y
Genetic
Background
SWR.129P2-Agtr2tm1Tin
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr2tm1Tin mutation (0 available); any Agtr2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• fewer 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-treated mice develop fewer and smaller lung tumors compared with similarly treated wild-type mice

homeostasis/metabolism
• fewer 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-treated mice develop fewer and smaller lung tumors compared with similarly treated wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory