Agtr1a^tm1Unc
Targeted Allele Detail

Summary

• Symbol: Agtr1a^tm1Unc
• Name: angiotensin II receptor, type 1a; targeted mutation 1, University of North Carolina
• MGI ID: MGI:1857147
• Synonyms: Agt1ar^-, Agtr1A-, Agtr1^tm1Unc, At1A-, AT1A-KO, AT1aR^-, AT1AR KO, AT1-R-
• Gene: Agtr1a Location: Chr13:30520424-30566850 bp, + strand Genetic Position: Chr13, 13.19 cM
• Alliance: Agtr1a^tm1Unc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:24354
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 0.5kb genomic fragment containing part of the coding sequences of the gene was replaced with a neomycin selection cassette. Binding studies in kidney indicated that no functional protein was detectable in homozygous mice. (J:24354)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Agtr1a Mutation: 40 strains or lines available

Notes

Kidneys of these null receptor mice are normal except for some expansion of renin-producing cells (J:45507).

References

• Original: J:24354 Ito M, et al., Regulation of blood pressure by the type 1A angiotensin II receptor gene. Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3521-5
• All: 137 reference(s)