Agtr1b^tm1Cof
Targeted Allele Detail

Summary

• Symbol: Agtr1b^tm1Cof
• Name: angiotensin II receptor, type 1b; targeted mutation 1, Thomas M Coffman
• MGI ID: MGI:2157020
• Synonyms: AT1b^-, AT1B-KO
• Gene: Agtr1b Location: Chr3:20368637-20421341 bp, - strand Genetic Position: Chr3, 6.37 cM
• Alliance: Agtr1b^tm1Cof page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51667
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 0.4kB genomic fragment containing part of the coding sequence was replaced with a neomycin selection cassette. RT-PCR analysis confirmed that the transcript was not detectable in adrenal glands of homozygous mice. (J:51667)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agtr1b Mutation: 18 strains or lines available

References

• Original: J:51667 Oliverio MI, et al., Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15496-501
• All: 23 reference(s)