All Phenotypes Agtr1b<tm1Cof> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Agtr1b^tm1Cof
targeted mutation 1, Thomas M Coffman
MGI:2157020

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Agtr1a^tm1Unc/Agtr1a^tm1Unc Agtr1b^tm1Cof/Agtr1b^tm1Cof Hprt1^{tm1(Ggt1-Agtr1)Cof}/Y	involves: 129P2/OlaHsd	MGI:3051600
cx2	Agtr1a^tm1Unc/Agtr1a^tm1Unc Agtr1b^tm1Cof/Agtr1b^tm1Cof Agtr2^tm1Tin/Agtr2^tm1Tin	involves: 129P2/OlaHsd * C57BL/6	MGI:4454284
cx3	Agtr1a^tm1Unc/Agtr1a^tm1Unc Agtr1b^tm1Cof/Agtr1b^tm1Cof Agtr2^tm1Tin/Y	involves: 129P2/OlaHsd * C57BL/6	MGI:4454285
cx4	Agtr1a^tm1Unc/Agtr1a^tm1Unc Agtr1b^tm1Cof/Agtr1b^tm1Cof	involves: 129P2/OlaHsd * C57BL/6	MGI:4454286
cx5	Agtr1b^tm1Cof/Agtr1b^tm1Cof Agtr2^tm1Tin/Y	involves: 129P2/OlaHsd * C57BL/6	MGI:4454287
cx6	Agtr1b^tm1Cof/Agtr1b^tm1Cof Agtr2^tm1Tin/Agtr2^tm1Tin	involves: 129P2/OlaHsd * C57BL/6	MGI:4454288

Allelic Composition	Agtr1a^tm1Unc/Agtr1a^tm1Unc Agtr1b^tm1Cof/Agtr1b^tm1Cof Hprt1^{tm1(Ggt1-Agtr1)Cof}/Y
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1a^tm1Unc mutation (1 available); any Agtr1a mutation (40 available)
Agtr1b^tm1Cof mutation (0 available); any Agtr1b mutation (18 available)
Hprt1^{tm1(Ggt1-Agtr1)Cof} mutation (0 available); any Hprt1 mutation (1274 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased renin activity ( J:91837 )

• renin levels reduced by 70% from levels found in mice homozygous for both Agtr1^tm1Unc and Agtr1b^tm1Cof

• renin levels essentially normal

renal/urinary system

kidney cyst ( J:91837 )

• greatly reduced number and size of glomerular and cortical cysts relative to the condition in mice homozygous for both Agtr1^tm1Unc and Agtr1b^tm1Cof

• architecture of the renal cortex is preserved

growth/size/body

kidney cyst ( J:91837 )

• greatly reduced number and size of glomerular and cortical cysts relative to the condition in mice homozygous for both Agtr1^tm1Unc and Agtr1b^tm1Cof

• architecture of the renal cortex is preserved

Allelic Composition	Agtr1a^tm1Unc/Agtr1a^tm1Unc Agtr1b^tm1Cof/Agtr1b^tm1Cof Agtr2^tm1Tin/Agtr2^tm1Tin
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1a^tm1Unc mutation (1 available); any Agtr1a mutation (40 available)
Agtr1b^tm1Cof mutation (0 available); any Agtr1b mutation (18 available)
Agtr2^tm1Tin mutation (0 available); any Agtr2 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:137944 )

• fewer than expected mice are present at weaning

cardiovascular system

decreased heart weight ( J:137944 )

abnormal heart rate ( J:137944 )

• compared with wild-type mice and Agtr1a^tm1Unc homozygotes

decreased heart rate ( J:137944 )

• compared with wild-type mice and Agtr1a^tm1Unc homozygotes

abnormal systemic arterial blood pressure ( J:137944 )

• Ang II-treated mice exhibit an almost completely blunted increase in mean arterial blood pressure (MAP) and heart rate with a shortened time to peak MAP and an increased time to normalization of MAP compared with similarly treated wild-type mice

• PE-treated mice exhibit a smaller increase in MAP compared with similarly treated wild-type mice

decreased mean systemic arterial blood pressure ( J:137944 )

• compared with wild-type mice and Agtr1a^tm1Unc homozygotes

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:137944 )

• angiotensin II (Ang II)-treated mice exhibit an almost completely blunted increase in mean arterial blood pressure (MAP) and heart rate with a shortened time to peak MAP and an increased time to normalization of MAP compared with similarly treated wild-type mice

• endothelin 1 (Et-1)-treated mice exhibit a positive chronotropic effect unlike wild-type mice

abnormal physiological response to xenobiotic ( J:137944 )

• phenylephrine (PE)-treated mice exhibit a smaller increase in MAP and fail to exhibit any chronotropic response compared with similarly treated wild-type mice

renal/urinary system

hydronephrosis ( J:137944 )

• in some mice

decreased kidney weight ( J:137944 )

• compared with wild type mice and Agtr1a^tm1Unc Agtr1b^tm1Cof double homozygotes

growth/size/body

decreased body weight ( J:137944 )

• compared with wild-type mice that is not as severe as in Agtr1a^tm1Unc Agtr1b^tm1Cof double homozygotes

Allelic Composition	Agtr1a^tm1Unc/Agtr1a^tm1Unc Agtr1b^tm1Cof/Agtr1b^tm1Cof Agtr2^tm1Tin/Y
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1a^tm1Unc mutation (1 available); any Agtr1a mutation (40 available)
Agtr1b^tm1Cof mutation (0 available); any Agtr1b mutation (18 available)
Agtr2^tm1Tin mutation (0 available); any Agtr2 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:137944 )

• fewer than expected mice are present at weaning

cardiovascular system

decreased heart weight ( J:137944 )

abnormal heart rate ( J:137944 )

• compared with wild-type mice and Agtr1a^tm1Unc homozygotes

decreased heart rate ( J:137944 )

• compared with wild-type mice and Agtr1a^tm1Unc homozygotes

abnormal systemic arterial blood pressure ( J:137944 )

• PE-treated mice exhibit a smaller increase in MAP compared with similarly treated wild-type mice

decreased mean systemic arterial blood pressure ( J:137944 )

• compared with wild-type mice and Agtr1a^tm1Unc homozygotes

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:137944 )

• endothelin 1 (Et-1)-treated mice exhibit a positive chronotropic effect unlike wild-type mice

abnormal physiological response to xenobiotic ( J:137944 )

• phenylephrine (PE)-treated mice exhibit a smaller increase in MAP and fail to exhibit any chronotropic response compared with similarly treated wild-type mice

renal/urinary system

hydronephrosis ( J:137944 )

• in some mice

decreased kidney weight ( J:137944 )

• compared with wild type mice and Agtr1a^tm1Unc Agtr1b^tm1Cof double homozygotes

growth/size/body

decreased body weight ( J:137944 )

• compared with wild-type mice that is not as severe as in Agtr1a^tm1Unc Agtr1b^tm1Cof double homozygotes

Allelic Composition	Agtr1a^tm1Unc/Agtr1a^tm1Unc Agtr1b^tm1Cof/Agtr1b^tm1Cof
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:137944 )

• fewer than expected mice are present at weaning

cardiovascular system

abnormal kidney vasculature morphology ( J:137944 )

• mice exhibit media hyperplasia of small and medium vessels unlike wild-type mice

decreased heart weight ( J:137944 )

• compared with wild-type mice and Agtr1a^tm1Unc homozygotes

decreased heart rate ( J:137944 )

abnormal systemic arterial blood pressure ( J:137944 )

• Ang II-treated mice exhibit an almost completely blunted increase in mean arterial blood pressure (MAP) and heart rate with an increased time to normalization of MAP compared with similarly treated wild-type mice

• PE-treated mice exhibit a smaller increase in MAP compared with similarly treated wild-type mice

decreased mean systemic arterial blood pressure ( J:137944 )

homeostasis/metabolism

abnormal circulating protein level ( J:137944 )

• serum levels of Ang II are increased compared to in wild-type mice and Agtr1b^tm1Cof homozygotes

abnormal response/metabolism to endogenous compounds ( J:137944 )

• angiotensin II (Ang II)-treated mice exhibit an almost completely blunted increase in mean arterial blood pressure (MAP) and heart rate with an increased time to normalization of MAP compared with similarly treated wild-type mice

abnormal physiological response to xenobiotic ( J:137944 )

• phenylephrine (PE)-treated mice exhibit a smaller increase in MAP compared with similarly treated wild-type mice

• however, PE-treated mice exhibit a negative chronotropic response as in wild-type mice

renal/urinary system

abnormal kidney vasculature morphology ( J:137944 )

• mice exhibit media hyperplasia of small and medium vessels unlike wild-type mice

kidney cyst ( J:137944 )

• mice exhibit cystic dilated cavities unlike wild-type mice

kidney inflammation ( J:137944 )

• mice exhibit prominent renal mononuclear infiltrations with partially blastic appearance and a high rate of partial mitosis unlike wild-type mice

increased glomerular capsule space ( J:137944 )

• severely dilated Bowman's space

renal glomerulus atrophy ( J:137944 )

• multifocal and focally extensive glomeruli atrophy

decreased kidney weight ( J:137944 )

dilated renal tubule ( J:137944 )

• partially dilated tubular lumina unlike in wild-type mice

growth/size/body

decreased body weight ( J:137944 )

kidney cyst ( J:137944 )

• mice exhibit cystic dilated cavities unlike wild-type mice

immune system

kidney inflammation ( J:137944 )

• mice exhibit prominent renal mononuclear infiltrations with partially blastic appearance and a high rate of partial mitosis unlike wild-type mice

Allelic Composition	Agtr1b^tm1Cof/Agtr1b^tm1Cof Agtr2^tm1Tin/Y
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1b^tm1Cof mutation (0 available); any Agtr1b mutation (18 available)
Agtr2^tm1Tin mutation (0 available); any Agtr2 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal renal glomerulus morphology ( J:137944 )

• mice exhibit hyperemic capillary loops unlike wild-type mice

• however, glomeruli are well perfused with distinct basal membranes

decreased kidney weight ( J:137944 )

cardiovascular system

increased mean systemic arterial blood pressure ( J:137944 )

growth/size/body

decreased body weight ( J:137944 )

Allelic Composition	Agtr1b^tm1Cof/Agtr1b^tm1Cof Agtr2^tm1Tin/Agtr2^tm1Tin
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal renal glomerulus morphology ( J:137944 )

• mice exhibit hyperemic capillary loops unlike wild-type mice

• however, glomeruli are well perfused with distinct basal membranes

decreased kidney weight ( J:137944 )

cardiovascular system

increased mean systemic arterial blood pressure ( J:137944 )

growth/size/body

decreased body weight ( J:137944 )

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