About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Insrtm1Dac
targeted mutation 1, Domenico Accili
MGI:1857204
Summary 22 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Insrtm1Dac/Insrtm1Dac involves: 129S4/SvJae * C57BL/6 MGI:2174959
ht2
Insrtm1Dac/Insr+ involves: 129 * C57BL/6J MGI:3802541
ht3
Insrtm1Dac/Insr+ involves: C3H/HeH * C57BL/6 MGI:3819944
cn4
Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Tg(Hsp70-1-cre)6Arge/?
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA MGI:4831153
cn5
Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Tg(Syn1-cre)671Jxm/?
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA MGI:4831155
cn6
Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Tg(Nes-cre)1Kln/?
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * SJL MGI:4831154
cn7
Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Tg(Camk2a-cre)#Szi/?
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J * CBA MGI:4831152
cn8
Insrtm1Khn/Insrtm1Dac
Tg(Ckmm-cre)5Khn/0
involves: 129S4/SvJae * C57BL/6J * FVB MGI:2389586
cx9
Gsk3btm1Jrw/Gsk3b+
Insrtm1Dac/Insr+
involves: 129 * C57BL/6J MGI:3802542
cx10
Igf1rtm1Arge/Igf1rtm1Arge
Insrtm1Dac/Insrtm1Dac
Insrrtm1Dac/Insrrtm1Dac
involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J MGI:3575085
cx11
Igf1rtm1Arge/Igf1rtm1Arge
Insrtm1Dac/Insr+
Insrrtm1Dac/Insrrtm1Dac
involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J MGI:3575092
cx12
Igf1rtm1Arge/Igf1rtm1Arge
Insrtm1Dac/Insrtm1Dac
involves: 129S/SvEv * 129S4/SvJae * C57BL/6J MGI:3575098
cx13
Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:4831156
cx14
Insrtm1Dac/Insr+
Irs2tm1Mfw/Irs2tm1Mfw
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:3653871
cx15
Insrtm1Dac/Insrtm1Dac
Insrrtm1Dac/Insrrtm1Dac
involves: 129S1/Sv * 129S4/SvJae * C57BL/6J MGI:2653026
cx16
Foxo1tm1Whb/Foxo1+
Insrtm1Dac/Insrtm1Dac
involves: 129S4/SvJae * C57BL/6 MGI:3653868
cx17
Foxo1tm1Whb/Foxo1+
Insrtm1Dac/Insr+
involves: 129S4/SvJae * C57BL/6 MGI:3653869
cx18
Foxo1tm2.1Dac/Foxo1tm2.1Dac
Insrtm1Dac/Insr+
involves: 129S4/SvJae * C57BL/6 MGI:5305588
cx19
Insrtm1Dac/Insrtm1Dac
Tg(TTR-INSR)L1Dac/0
involves: 129S4/SvJae * C57BL/6 * FVB MGI:4831149
cx20
Insrtm1Dac/Insrtm1Dac
Tg(TTR-INSR)L2Dac/0
involves: 129S4/SvJae * C57BL/6 * FVB MGI:4831150
cx21
Insrtm1Dac/Insrtm1Dac
Tg(TTR-INSR)L3Dac/0
involves: 129S4/SvJae * C57BL/6 * FVB MGI:4831151
cx22
Insrtm1Dac/Insr+
Sox4Igt4/Sox4+
involves: C3H/HeH * C57BL/6 MGI:3819939


Genotype
MGI:2174959
hm1
Allelic
Composition
Insrtm1Dac/Insrtm1Dac
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insrtm1Dac mutation (2 available); any Insr mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die within 72 hours of birth

homeostasis/metabolism
• about 10% with diabetes
• plasma glucose levels rose sharply after birth; measured between 24-37 mmol/l
• plasma insulin levels rose sharply after birth to levels approximately 7 times that of controls
• homozygous mice developed diabetic ketoacidosis, with ketone bodies in urine; urinary acetoacetate measured between 8-16 mmol/l

liver/biliary system
• steatosis; fatty degeneration of liver

renal/urinary system
• homozygous mice developed diabetic ketoacidosis, with ketone bodies in urine; urinary acetoacetate measured between 8-16 mmol/l

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Donohue Syndrome 246200 J:33408




Genotype
MGI:3802541
ht2
Allelic
Composition
Insrtm1Dac/Insr+
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insrtm1Dac mutation (2 available); any Insr mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• both fasting and fed insulin levels were higher than in wild-type mice

endocrine/exocrine glands
• increased beta cell mass




Genotype
MGI:3819944
ht3
Allelic
Composition
Insrtm1Dac/Insr+
Genetic
Background
involves: C3H/HeH * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insrtm1Dac mutation (2 available); any Insr mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• beta islet cells secrete about twice as much insulin as controls in the absence of extracellular glucose

homeostasis/metabolism
• beta islet cells secrete about twice as much insulin as controls in the absence of extracellular glucose
• circulating insulin levels are almost 3-fold higher and continue to remain higher than controls during a glucose challenge




Genotype
MGI:4831153
cn4
Allelic
Composition
Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Tg(Hsp70-1-cre)6Arge/?
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actbtm1(INSR)Dac mutation (0 available); any Actb mutation (22 available)
Insrtm1Dac mutation (2 available); any Insr mutation (45 available)
Tg(Hsp70-1-cre)6Arge mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die between 6 and 8 weeks

homeostasis/metabolism
• diabetic in one week
• extremely elevated




Genotype
MGI:4831155
cn5
Allelic
Composition
Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Tg(Syn1-cre)671Jxm/?
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actbtm1(INSR)Dac mutation (0 available); any Actb mutation (22 available)
Insrtm1Dac mutation (2 available); any Insr mutation (45 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die between 6 and 8 weeks

homeostasis/metabolism
• diabetic in one week
• extremely elevated




Genotype
MGI:4831154
cn6
Allelic
Composition
Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Tg(Nes-cre)1Kln/?
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actbtm1(INSR)Dac mutation (0 available); any Actb mutation (22 available)
Insrtm1Dac mutation (2 available); any Insr mutation (45 available)
Tg(Nes-cre)1Kln mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die between 6 and 8 weeks

homeostasis/metabolism
• diabetic in one week
• extremely elevated




Genotype
MGI:4831152
cn7
Allelic
Composition
Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Tg(Camk2a-cre)#Szi/?
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actbtm1(INSR)Dac mutation (0 available); any Actb mutation (22 available)
Insrtm1Dac mutation (2 available); any Insr mutation (45 available)
Tg(Camk2a-cre)#Szi mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die between 6 and 8 weeks

homeostasis/metabolism
• diabetic in one week
• extremely elevated




Genotype
MGI:2389586
cn8
Allelic
Composition
Insrtm1Khn/Insrtm1Dac
Tg(Ckmm-cre)5Khn/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insrtm1Dac mutation (2 available); any Insr mutation (45 available)
Insrtm1Khn mutation (1 available); any Insr mutation (45 available)
Tg(Ckmm-cre)5Khn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• in the fed state, incomplete penetrance




Genotype
MGI:3802542
cx9
Allelic
Composition
Gsk3btm1Jrw/Gsk3b+
Insrtm1Dac/Insr+
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsk3btm1Jrw mutation (0 available); any Gsk3b mutation (94 available)
Insrtm1Dac mutation (2 available); any Insr mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• decreased fasting glucose level relative to those in Insrtm1Dac heterozygous mice
• the rate of glucose disposal and glucose infusion were increased relative to those in Insrtm1Dac heterozygous mice
• hepatic glucose production is comparable to that in Insrtm1Dac heterozygous mice
• the serum insulin values were significantly decreased relative to those in Insrtm1Dac heterozygous mice in both the fasting and the fed state
• the values were significantly elevated relative to that in Gsk3btm1Jrw heterozygous mice
• compared to Insrtm1Dac heterozygous mice
• improved over Insrtm1Dac heterozygous mice, but still insulin resistant compared to wild-type

endocrine/exocrine glands
• reduced beta cell mass over Insrtm1Dac heterozygous mice




Genotype
MGI:3575085
cx10
Allelic
Composition
Igf1rtm1Arge/Igf1rtm1Arge
Insrtm1Dac/Insrtm1Dac
Insrrtm1Dac/Insrrtm1Dac
Genetic
Background
involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1Arge mutation (0 available); any Igf1r mutation (39 available)
Insrrtm1Dac mutation (0 available); any Insrr mutation (30 available)
Insrtm1Dac mutation (2 available); any Insr mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• XY mice at E17.5 showed gonad location and histology consistent with ovary development
• cause inferred as decrease in proliferation of Sry -expressing cells




Genotype
MGI:3575092
cx11
Allelic
Composition
Igf1rtm1Arge/Igf1rtm1Arge
Insrtm1Dac/Insr+
Insrrtm1Dac/Insrrtm1Dac
Genetic
Background
involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1Arge mutation (0 available); any Igf1r mutation (39 available)
Insrrtm1Dac mutation (0 available); any Insrr mutation (30 available)
Insrtm1Dac mutation (2 available); any Insr mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• XY mice may develop testes, ovotestes, and/or ovaries
• gonad type is suggested by degree of gonadal descent and histological analyses




Genotype
MGI:3575098
cx12
Allelic
Composition
Igf1rtm1Arge/Igf1rtm1Arge
Insrtm1Dac/Insrtm1Dac
Genetic
Background
involves: 129S/SvEv * 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1Arge mutation (0 available); any Igf1r mutation (39 available)
Insrtm1Dac mutation (2 available); any Insr mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• determined by partial descent of gonads and histological analyses showing ovarian and testicular tissue
• partial male-to-female sex reversal is observed




Genotype
MGI:4831156
cx13
Allelic
Composition
Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actbtm1(INSR)Dac mutation (0 available); any Actb mutation (22 available)
Insrtm1Dac mutation (2 available); any Insr mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die within a few days of birth

homeostasis/metabolism
• diabetic ketosis
• cause of early death




Genotype
MGI:3653871
cx14
Allelic
Composition
Insrtm1Dac/Insr+
Irs2tm1Mfw/Irs2tm1Mfw
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insrtm1Dac mutation (2 available); any Insr mutation (45 available)
Irs2tm1Mfw mutation (1 available); any Irs2 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

homeostasis/metabolism
• diabetic at 6 to 8 weeks of age

endocrine/exocrine glands
• undetectable at 8 weeks of age




Genotype
MGI:2653026
cx15
Allelic
Composition
Insrtm1Dac/Insrtm1Dac
Insrrtm1Dac/Insrrtm1Dac
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insrrtm1Dac mutation (0 available); any Insrr mutation (30 available)
Insrtm1Dac mutation (2 available); any Insr mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die within 5 days of birth

homeostasis/metabolism
• similar to Insr mutant mice; plasma glucose levels rose sharply after birth
• similar to Insr mutant mice; plasma insulin levels rose sharply after birth
• compound homozygous mice developed diabetic ketoacidosis, with ketone bodies in urine

renal/urinary system
• compound homozygous mice developed diabetic ketoacidosis, with ketone bodies in urine




Genotype
MGI:3653868
cx16
Allelic
Composition
Foxo1tm1Whb/Foxo1+
Insrtm1Dac/Insrtm1Dac
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1Whb mutation (0 available); any Foxo1 mutation (11 available)
Insrtm1Dac mutation (2 available); any Insr mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• due to diabetic ketoacidosis

homeostasis/metabolism
• 25% reduction in glucose levels relative to Insrtm1Dac homozygotes




Genotype
MGI:3653869
cx17
Allelic
Composition
Foxo1tm1Whb/Foxo1+
Insrtm1Dac/Insr+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1Whb mutation (0 available); any Foxo1 mutation (11 available)
Insrtm1Dac mutation (2 available); any Insr mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• normal insulin and glucose levels at both 2 and 6 months
• no diabetes




Genotype
MGI:5305588
cx18
Allelic
Composition
Foxo1tm2.1Dac/Foxo1tm2.1Dac
Insrtm1Dac/Insr+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm2.1Dac mutation (0 available); any Foxo1 mutation (11 available)
Insrtm1Dac mutation (2 available); any Insr mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• in fasted and re-fed mice
• slightly impaired hypoglycemic response in an insulin intolerance test




Genotype
MGI:4831149
cx19
Allelic
Composition
Insrtm1Dac/Insrtm1Dac
Tg(TTR-INSR)L1Dac/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insrtm1Dac mutation (2 available); any Insr mutation (45 available)
Tg(TTR-INSR)L1Dac mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• weigh 80% of control mice
• limited recovery from low birth weight

homeostasis/metabolism
• glucose levels remain normal in 90% of mice at 2 months of age
• 35% are diabetic at 6 months
• life spans remain normal
• 10% increase in resting energy expenditure

endocrine/exocrine glands
• moderately decreased
• islets are otherwise normal

reproductive system
N
• normal fertility




Genotype
MGI:4831150
cx20
Allelic
Composition
Insrtm1Dac/Insrtm1Dac
Tg(TTR-INSR)L2Dac/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insrtm1Dac mutation (2 available); any Insr mutation (45 available)
Tg(TTR-INSR)L2Dac mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die between 3 weeks and 8 months

growth/size/body
• remain growth retarded throughout life

adipose tissue
• lack white adipose tissue

liver/biliary system
• hepatomegaly
• fatty liver degeneration

homeostasis/metabolism
• diabetic at 2 months

endocrine/exocrine glands
• extensive loss of insulin positive cells at 4 months

reproductive system




Genotype
MGI:4831151
cx21
Allelic
Composition
Insrtm1Dac/Insrtm1Dac
Tg(TTR-INSR)L3Dac/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insrtm1Dac mutation (2 available); any Insr mutation (45 available)
Tg(TTR-INSR)L3Dac mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die between 3 weeks and 8 months

growth/size/body
• weight is 60% of controls
• remain growth retarded throughout life

adipose tissue
• lack white adipose tissue

liver/biliary system
• hepatomegaly
• fatty liver degeneration

homeostasis/metabolism
• diabetic at 2 months
• by four weeks

endocrine/exocrine glands
• extensive loss of insulin positive cells at 4 months

reproductive system




Genotype
MGI:3819939
cx22
Allelic
Composition
Insrtm1Dac/Insr+
Sox4Igt4/Sox4+
Genetic
Background
involves: C3H/HeH * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insrtm1Dac mutation (2 available); any Insr mutation (45 available)
Sox4Igt4 mutation (0 available); any Sox4 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• these mice have impaired glucose tolerance with glucose levels significantly higher than controls 60 and 120 minutes after glucose administration
• the glucose levels are higher than in mice carrying the mutant Sox4 allele on a background that is homozygote for the wild-type allele of Insr





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory