All Phenotypes Insr<tm1Dac> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Insr^tm1Dac
targeted mutation 1, Domenico Accili
MGI:1857204

Summary

24 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Insr^tm1Dac/Insr^tm1Dac	involves: 129S4/SvJae * C57BL/6	MGI:2174959
ht2	Insr^tm1Dac/Insr⁺	B6.129S4-Insr^tm1Dac/J	MGI:6160735
ht3	Insr^tm1Dac/Insr⁺	involves: 129 * C57BL/6J	MGI:3802541
ht4	Insr^tm1Dac/Insr⁺	involves: C3H/HeH * C57BL/6	MGI:3819944
cn5	Actb^tm1(INSR)Dac/Actb^tm1(INSR)Dac Insr^tm1Dac/Insr^tm1Dac Tg(Syn1-cre)671Jxm/?	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA	MGI:4831155
cn6	Actb^tm1(INSR)Dac/Actb^tm1(INSR)Dac Insr^tm1Dac/Insr^tm1Dac Tg(Hsp70-1-cre)6Arge/?	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA	MGI:4831153
cn7	Actb^tm1(INSR)Dac/Actb^tm1(INSR)Dac Insr^tm1Dac/Insr^tm1Dac Tg(Camk2a-cre)#Szi/?	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J * CBA	MGI:4831152
cn8	Actb^tm1(INSR)Dac/Actb^tm1(INSR)Dac Insr^tm1Dac/Insr^tm1Dac Tg(Nes-cre)1Kln/?	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * SJL	MGI:4831154
cn9	Insr^tm1Khn/Insr^tm1Dac Tg(Ckmm-cre)5Khn/0	involves: 129S4/SvJae * C57BL/6J * FVB	MGI:2389586
cx10	Gsk3b^tm1Jrw/Gsk3b⁺ Insr^tm1Dac/Insr⁺	involves: 129 * C57BL/6J	MGI:3802542
cx11	Actb^tm1(INSR)Dac/Actb^tm1(INSR)Dac Insr^tm1Dac/Insr^tm1Dac	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:4831156
cx12	Insr^tm1Dac/Insr⁺ Irs2^tm1Mfw/Irs2^tm1Mfw	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:3653871
cx13	Insr^tm1Dac/Insr^tm1Dac Insrr^tm1Dac/Insrr^tm1Dac	involves: 129S1/Sv * 129S4/SvJae * C57BL/6J	MGI:2653026
cx14	Insr^tm1Dac/Insr⁺ Ppp2r2a^igt10/Ppp2r2a⁺	involves: 129S4/SvJae * C3H/HeH * C57BL/6J	MGI:6160731
cx15	Foxo1^tm1Whb/Foxo1⁺ Insr^tm1Dac/Insr⁺	involves: 129S4/SvJae * C57BL/6	MGI:3653869
cx16	Foxo1^tm2.1Dac/Foxo1^tm2.1Dac Insr^tm1Dac/Insr⁺	involves: 129S4/SvJae * C57BL/6	MGI:5305588
cx17	Foxo1^tm1Whb/Foxo1⁺ Insr^tm1Dac/Insr^tm1Dac	involves: 129S4/SvJae * C57BL/6	MGI:3653868
cx18	Insr^tm1Dac/Insr^tm1Dac Tg(TTR-INSR)L3Dac/0	involves: 129S4/SvJae * C57BL/6 * FVB	MGI:4831151
cx19	Insr^tm1Dac/Insr^tm1Dac Tg(TTR-INSR)L2Dac/0	involves: 129S4/SvJae * C57BL/6 * FVB	MGI:4831150
cx20	Insr^tm1Dac/Insr^tm1Dac Tg(TTR-INSR)L1Dac/0	involves: 129S4/SvJae * C57BL/6 * FVB	MGI:4831149
cx21	Igf1r^tm1Arge/Igf1r^tm1Arge Insr^tm1Dac/Insr^tm1Dac Insrr^tm1Dac/Insrr^tm1Dac	involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J	MGI:3575085
cx22	Igf1r^tm1Arge/Igf1r^tm1Arge Insr^tm1Dac/Insr⁺ Insrr^tm1Dac/Insrr^tm1Dac	involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J	MGI:3575092
cx23	Igf1r^tm1Arge/Igf1r^tm1Arge Insr^tm1Dac/Insr^tm1Dac	involves: 129S/SvEv * 129S4/SvJae * C57BL/6J	MGI:3575098
cx24	Insr^tm1Dac/Insr⁺ Sox4^Igt4/Sox4⁺	involves: C3H/HeH * C57BL/6	MGI:3819939

Allelic Composition	Insr^tm1Dac/Insr^tm1Dac
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insr^tm1Dac mutation (2 available); any Insr mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:33408 )

• mice die within 72 hours of birth

homeostasis/metabolism

abnormal glucose homeostasis ( J:79560 )

• about 10% with diabetes

hyperglycemia ( J:33408 )

• plasma glucose levels rose sharply after birth; measured between 24-37 mmol/l

increased circulating insulin level ( J:33408 )

• plasma insulin levels rose sharply after birth to levels approximately 7 times that of controls

ketoaciduria ( J:33408 )

• homozygous mice developed diabetic ketoacidosis, with ketone bodies in urine; urinary acetoacetate measured between 8-16 mmol/l

liver/biliary system

hepatic steatosis ( J:33408 )

• steatosis; fatty degeneration of liver

renal/urinary system

ketoaciduria ( J:33408 )

• homozygous mice developed diabetic ketoacidosis, with ketone bodies in urine; urinary acetoacetate measured between 8-16 mmol/l

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	Donohue syndrome	DOID:0050470	OMIM:246200	J:33408

Allelic Composition	Insr^tm1Dac/Insr⁺
Genetic Background	B6.129S4-Insr^tm1Dac/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insr^tm1Dac mutation (2 available); any Insr mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased pancreatic beta cell mass ( J:246319 )

homeostasis/metabolism

increased circulating insulin level ( J:246319 )

insulin resistance ( J:246319 )

Allelic Composition	Insr^tm1Dac/Insr⁺
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insr^tm1Dac mutation (2 available); any Insr mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating insulin level ( J:135659 )

• both fasting and fed insulin levels were higher than in wild-type mice

insulin resistance ( J:135659 )

endocrine/exocrine glands

increased pancreatic beta cell mass ( J:135659 )

• increased beta cell mass

Allelic Composition	Insr^tm1Dac/Insr⁺
Genetic Background	involves: C3H/HeH * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insr^tm1Dac mutation (2 available); any Insr mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased insulin secretion ( J:141688 )

• beta islet cells secrete about twice as much insulin as controls in the absence of extracellular glucose

homeostasis/metabolism

increased insulin secretion ( J:141688 )

• beta islet cells secrete about twice as much insulin as controls in the absence of extracellular glucose

increased circulating insulin level ( J:141688 )

• circulating insulin levels are almost 3-fold higher and continue to remain higher than controls during a glucose challenge

Allelic Composition	Actb^tm1(INSR)Dac/Actb^tm1(INSR)Dac Insr^tm1Dac/Insr^tm1Dac Tg(Syn1-cre)671Jxm/?
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actb^tm1(INSR)Dac mutation (0 available); any Actb mutation (51 available)
Insr^tm1Dac mutation (2 available); any Insr mutation (94 available)
Tg(Syn1-cre)671Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:91350 )

• die between 6 and 8 weeks

homeostasis/metabolism

increased circulating glucose level ( J:91350 )

• diabetic in one week

increased circulating insulin level ( J:91350 )

• extremely elevated

Allelic Composition	Actb^tm1(INSR)Dac/Actb^tm1(INSR)Dac Insr^tm1Dac/Insr^tm1Dac Tg(Hsp70-1-cre)6Arge/?
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:91350 )

• die between 6 and 8 weeks

homeostasis/metabolism

increased circulating glucose level ( J:91350 )

• diabetic in one week

increased circulating insulin level ( J:91350 )

• extremely elevated

Allelic Composition	Actb^tm1(INSR)Dac/Actb^tm1(INSR)Dac Insr^tm1Dac/Insr^tm1Dac Tg(Camk2a-cre)#Szi/?
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:91350 )

• die between 6 and 8 weeks

homeostasis/metabolism

increased circulating glucose level ( J:91350 )

• diabetic in one week

increased circulating insulin level ( J:91350 )

• extremely elevated

Allelic Composition	Actb^tm1(INSR)Dac/Actb^tm1(INSR)Dac Insr^tm1Dac/Insr^tm1Dac Tg(Nes-cre)1Kln/?
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:91350 )

• die between 6 and 8 weeks

homeostasis/metabolism

increased circulating glucose level ( J:91350 )

• diabetic in one week

increased circulating insulin level ( J:91350 )

• extremely elevated

Allelic Composition	Insr^tm1Khn/Insr^tm1Dac Tg(Ckmm-cre)5Khn/0
Genetic Background	involves: 129S4/SvJae * C57BL/6J * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insr^tm1Dac mutation (2 available); any Insr mutation (94 available)
Insr^tm1Khn mutation (1 available); any Insr mutation (94 available)
Tg(Ckmm-cre)5Khn mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

hyperglycemia ( J:51266 )

• in the fed state, incomplete penetrance

increased circulating insulin level ( J:51266 )

Allelic Composition	Gsk3b^tm1Jrw/Gsk3b⁺ Insr^tm1Dac/Insr⁺
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsk3b^tm1Jrw mutation (0 available); any Gsk3b mutation (111 available)
Insr^tm1Dac mutation (2 available); any Insr mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal circulating glucose level ( J:135659 )

• decreased fasting glucose level relative to those in Insr^tm1Dac heterozygous mice

• the rate of glucose disposal and glucose infusion were increased relative to those in Insr^tm1Dac heterozygous mice

• hepatic glucose production is comparable to that in Insr^tm1Dac heterozygous mice

abnormal circulating insulin level ( J:135659 )

• the serum insulin values were significantly decreased relative to those in Insr^tm1Dac heterozygous mice in both the fasting and the fed state

• the values were significantly elevated relative to that in Gsk3b^tm1Jrw heterozygous mice

improved glucose tolerance ( J:135659 )

• compared to Insr^tm1Dac heterozygous mice

insulin resistance ( J:135659 )

• improved over Insr^tm1Dac heterozygous mice, but still insulin resistant compared to wild-type

endocrine/exocrine glands

decreased pancreatic beta cell mass ( J:135659 )

• reduced beta cell mass over Insr^tm1Dac heterozygous mice

Allelic Composition	Actb^tm1(INSR)Dac/Actb^tm1(INSR)Dac Insr^tm1Dac/Insr^tm1Dac
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:91350 )

• die within a few days of birth

homeostasis/metabolism

increased circulating ketone body level ( J:91350 )

• diabetic ketosis

• cause of early death

Allelic Composition	Insr^tm1Dac/Insr⁺ Irs2^tm1Mfw/Irs2^tm1Mfw
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insr^tm1Dac mutation (2 available); any Insr mutation (94 available)
Irs2^tm1Mfw mutation (1 available); any Irs2 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:80826 )

homeostasis/metabolism

abnormal glucose homeostasis ( J:80826 )

• diabetic at 6 to 8 weeks of age

endocrine/exocrine glands

absent pancreatic beta cells ( J:80826 )

• undetectable at 8 weeks of age

Allelic Composition	Insr^tm1Dac/Insr^tm1Dac Insrr^tm1Dac/Insrr^tm1Dac
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insrr^tm1Dac mutation (0 available); any Insrr mutation (62 available)
Insr^tm1Dac mutation (2 available); any Insr mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:70602 )

• mice die within 5 days of birth

homeostasis/metabolism

hyperglycemia ( J:70602 )

• similar to Insr mutant mice; plasma glucose levels rose sharply after birth

increased circulating insulin level ( J:70602 )

• similar to Insr mutant mice; plasma insulin levels rose sharply after birth

impaired glucose tolerance ( J:70602 )

ketoaciduria ( J:70602 )

• compound homozygous mice developed diabetic ketoacidosis, with ketone bodies in urine

renal/urinary system

ketoaciduria ( J:70602 )

• compound homozygous mice developed diabetic ketoacidosis, with ketone bodies in urine

Allelic Composition	Insr^tm1Dac/Insr⁺ Ppp2r2a^igt10/Ppp2r2a⁺
Genetic Background	involves: 129S4/SvJae * C3H/HeH * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insr^tm1Dac mutation (2 available); any Insr mutation (94 available)
Ppp2r2a^igt10 mutation (0 available); any Ppp2r2a mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

hyperglycemia ( J:246319 )

• mice exhibit elevated plasma glucose levels from 18 weeks

increased circulating insulin level ( J:246319 )

• plasma insulin levels are elevated more than in either single heterozygote

impaired glucose tolerance ( J:246319 )

• mice show impaired glucose tolerance at 12 weeks of age

increased urine glucose level ( J:246319 )

• mice exhibit glycosuria by 28 weeks of age

insulin resistance ( J:246319 )

renal/urinary system

increased urine glucose level ( J:246319 )

• mice exhibit glycosuria by 28 weeks of age

behavior/neurological

polydipsia ( J:246319 )

• mice drink more and produce more urine as glycosuria develops

endocrine/exocrine glands

increased pancreatic beta cell mass ( J:246319 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:246319

Allelic Composition	Foxo1^tm1Whb/Foxo1⁺ Insr^tm1Dac/Insr⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^tm1Whb mutation (0 available); any Foxo1 mutation (31 available)
Insr^tm1Dac mutation (2 available); any Insr mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:79560 )

N	• normal insulin and glucose levels at both 2 and 6 months • no diabetes

Allelic Composition	Foxo1^tm2.1Dac/Foxo1^tm2.1Dac Insr^tm1Dac/Insr⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^tm2.1Dac mutation (0 available); any Foxo1 mutation (31 available)
Insr^tm1Dac mutation (2 available); any Insr mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating insulin level ( J:179687 )

• in fasted and re-fed mice

insulin resistance ( J:179687 )

• slightly impaired hypoglycemic response in an insulin intolerance test

Allelic Composition	Foxo1^tm1Whb/Foxo1⁺ Insr^tm1Dac/Insr^tm1Dac
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:79560 )

• due to diabetic ketoacidosis

homeostasis/metabolism

decreased circulating glucose level ( J:79560 )

• 25% reduction in glucose levels relative to Insr^tm1Dac homozygotes

Allelic Composition	Insr^tm1Dac/Insr^tm1Dac Tg(TTR-INSR)L3Dac/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insr^tm1Dac mutation (2 available); any Insr mutation (94 available)
Tg(TTR-INSR)L3Dac mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:91350 )

• die between 3 weeks and 8 months

growth/size/body

decreased birth weight ( J:91350 )

• weight is 60% of controls

postnatal growth retardation ( J:91350 )

• remain growth retarded throughout life

enlarged liver ( J:91350 )

• hepatomegaly

adipose tissue

decreased white adipose tissue amount ( J:91350 )

• lack white adipose tissue

liver/biliary system

enlarged liver ( J:91350 )

• hepatomegaly

decreased liver glycogen level ( J:91350 )

hepatic steatosis ( J:91350 )

liver degeneration ( J:91350 )

• fatty liver degeneration

abnormal liver physiology ( J:91350 )

homeostasis/metabolism

increased circulating glucose level ( J:91350 )

• diabetic at 2 months

hyperglycemia ( J:91350 )

• by four weeks

increased circulating insulin level ( J:91350 )

decreased liver glycogen level ( J:91350 )

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:91350 )

• extensive loss of insulin positive cells at 4 months

increased pancreatic beta cell mass ( J:91350 )

• increased 3 fold

reproductive system

female infertility ( J:91350 )

Allelic Composition	Insr^tm1Dac/Insr^tm1Dac Tg(TTR-INSR)L2Dac/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insr^tm1Dac mutation (2 available); any Insr mutation (94 available)
Tg(TTR-INSR)L2Dac mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:91350 )

• die between 3 weeks and 8 months

growth/size/body

decreased birth weight ( J:91350 )

postnatal growth retardation ( J:91350 )

• remain growth retarded throughout life

enlarged liver ( J:91350 )

• hepatomegaly

adipose tissue

decreased white adipose tissue amount ( J:91350 )

• lack white adipose tissue

liver/biliary system

enlarged liver ( J:91350 )

• hepatomegaly

decreased liver glycogen level ( J:91350 )

hepatic steatosis ( J:91350 )

liver degeneration ( J:91350 )

• fatty liver degeneration

abnormal liver physiology ( J:91350 )

homeostasis/metabolism

increased circulating glucose level ( J:91350 )

• diabetic at 2 months

increased circulating insulin level ( J:91350 )

decreased liver glycogen level ( J:91350 )

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:91350 )

• extensive loss of insulin positive cells at 4 months

increased pancreatic beta cell mass ( J:91350 )

• increased 2 fold

reproductive system

female infertility ( J:91350 )

Allelic Composition	Insr^tm1Dac/Insr^tm1Dac Tg(TTR-INSR)L1Dac/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insr^tm1Dac mutation (2 available); any Insr mutation (94 available)
Tg(TTR-INSR)L1Dac mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased birth weight ( J:91350 )

• weigh 80% of control mice

increased growth rate ( J:91350 )

• limited recovery from low birth weight

homeostasis/metabolism

increased circulating glucose level ( J:91350 )

• glucose levels remain normal in 90% of mice at 2 months of age

• 35% are diabetic at 6 months

• life spans remain normal

increased circulating insulin level ( J:91350 )

increased energy expenditure ( J:91350 )

• 10% increase in resting energy expenditure

endocrine/exocrine glands

decreased pancreatic beta cell mass ( J:91350 )

• moderately decreased

• islets are otherwise normal

reproductive system

reproductive system phenotype ( J:91350 )

N	• normal fertility

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Insr^tm1Dac/Insr^tm1Dac Insrr^tm1Dac/Insrr^tm1Dac
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (86 available)
Insrr^tm1Dac mutation (0 available); any Insrr mutation (62 available)
Insr^tm1Dac mutation (2 available); any Insr mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal primary sex determination ( J:86618 )

primary sex reversal ( J:86618 )

• XY mice at E17.5 showed gonad location and histology consistent with ovary development

• cause inferred as decrease in proliferation of Sry -expressing cells

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Insr^tm1Dac/Insr⁺ Insrr^tm1Dac/Insrr^tm1Dac
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal primary sex determination ( J:86618 )

primary sex reversal ( J:86618 )

• XY mice may develop testes, ovotestes, and/or ovaries

• gonad type is suggested by degree of gonadal descent and histological analyses

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Insr^tm1Dac/Insr^tm1Dac
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (86 available)
Insr^tm1Dac mutation (2 available); any Insr mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

ovotestis ( J:86618 )

• determined by partial descent of gonads and histological analyses showing ovarian and testicular tissue

primary sex reversal ( J:86618 )

• partial male-to-female sex reversal is observed

Allelic Composition	Insr^tm1Dac/Insr⁺ Sox4^Igt4/Sox4⁺
Genetic Background	involves: C3H/HeH * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insr^tm1Dac mutation (2 available); any Insr mutation (94 available)
Sox4^Igt4 mutation (0 available); any Sox4 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

impaired glucose tolerance ( J:141688 )

• these mice have impaired glucose tolerance with glucose levels significantly higher than controls 60 and 120 minutes after glucose administration

• the glucose levels are higher than in mice carrying the mutant Sox4 allele on a background that is homozygote for the wild-type allele of Insr

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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