Sox4Igt4
Chemically induced Allele Detail
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Symbol: |
Sox4Igt4 |
Name: |
SRY (sex determining region Y)-box 4; Impaired glucose tolerance 4 |
MGI ID: |
MGI:3819788 |
Synonyms: |
Sox4-Y123C |
Gene: |
Sox4 Location: Chr13:29132902-29137682 bp, - strand Genetic Position: Chr13, 12.87 cM, cytoband A3-A5
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Alliance: |
Sox4Igt4 page
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Allele Type: |
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Chemically induced (ENU) |
Mutation: |
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Single point mutation
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Mutation details: Male mice heterozygote for the Insrtm1Dac allele were treated with ENU and their offspring were screened for impaired glucose tolerance. One line derived from this screen was found to have a single A to G mutation at nucleotide position 1,025 of this gene locus. This corresponded to a tyrosine to cysteine substitution at amino acid 123 (Y123C), which lies in the highly conserved HMG-binding domain. Allelic complementation suggests that this is a functionally null allele.
(J:141688)
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Inheritance: |
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Dominant |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Sox4 Mutation: |
20 strains or lines available
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Original: |
J:141688 Goldsworthy M, et al., Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance. Diabetes. 2008 Aug;57(8):2234-44 |
All: |
2 reference(s) |
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