Analysis Tools
mortality/aging
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• mice die in utero around E14.5
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Allele Symbol Allele Name Allele ID |
Sox4Igt4 Impaired glucose tolerance 4 MGI:3819788 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die in utero around E14.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the amount of insulin secreted by beta-islet cells in response to glucose is much less with a 70% reduction in the amount secreted in response to 20 mmol glucose
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• circulating insulin levels are significantly lower 10 to 30 minutes after a glucose challenge
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• these mice have impaired glucose tolerance with glucose levels significantly higher 60 minutes after glucose administration
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• the amount of insulin secreted by beta-islet cells in response to glucose is much less with a 70% reduction in the amount secreted in response to 20 mmol glucose
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die in utero around E14.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die in utero around E14.5
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• hypoplastic or interrupted aortic arches are observed in E14.5 fetuses
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• the aorta and pulmonary artery both originate from the right ventricle
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• the atrioventricular valves of E14.5 embryos are dysplastic
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• a large outlet ventricular septum defect connects the left and right ventricles
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• 60% of E14.5 embryos have cleft palate
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• 60% of E14.5 embryos have cleft palate
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• bilateral hypoplasia of the thymus is noted in one case
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• severe edema is observed in the extremities of the E14.5 fetus
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• bilateral hypoplasia of the thymus is noted in one case
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• bilateral renal hypoplasia is noted in one case
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• bilateral hypoplasia of the thymus is noted in one case
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• 60% of E14.5 embryos have cleft palate
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• these mice have impaired glucose tolerance with glucose levels significantly higher than controls 60 and 120 minutes after glucose administration
• the glucose levels are higher than in mice carrying the mutant Sox4 allele on a background that is homozygote for the wild-type allele of Insr
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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