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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
A
wild-type agouti
MGI:1856464
Summary 33 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
A/A Not Specified MGI:5460857
ht2
Ahvy/A B6.C3-Bpifa2a Ahvy MGI:4453172
ht3
Aiy/A C3H/HeJ-Aiy MGI:3821616
ht4
Aw-47J/A C57BL/6J MGI:2181396
ht5
A/atl involves: 101/H * C3H/HeH MGI:5471527
ht6
Ay/A involves: C3H/HeJ * C57BL/6J-Ay/a MGI:5086113
ht7
Ay/A involves: C57BL/6 MGI:3773447
ht8
Ay-Jkn/A involves: C57BL/6N MGI:3805937
ht9
A/atwp Not Specified MGI:4367212
cx10
A/a
In(11Trp53;11Wnt3)8Brd/+
either: (involves: 129S7/SvEvBrd * C57BL/6Brd) or (involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6Brd) or (involves: 129S5/SvEvBrd * C57BL/6Brd * C57BL/6J) MGI:5766498
cx11
As/As
A/A
involves: 101/H * C3H/HeH MGI:4418456
cx12
a/A
Pomctm1Sora/Pomctm1Sora
involves: 129S6/SvEvTac MGI:3805940
cx13
a/A
Mc1re/Mc1re
Pomctm1Sora/Pomctm1Sora
Tg(MC1R)1Jkn/?
involves: 129S6/SvEvTac * C57BL/6Ha MGI:3805942
cx14
A/?
DctSlt-lt/DctSlt-lt
involves: C3H/HeJ MGI:3027715
cx15
A/?
DctSlt-lt/Dct+
involves: C3H/HeJ MGI:3576263
cx16
Ay/A
Pepddal/Pepddal
involves: C3H/HeJ * CBA/J MGI:5605663
cx17
Ay/A
Prkar2btm2Gsm/Prkar2btm2Gsm
involves: C57BL/6 MGI:3773448
cx18
Ay/A
Prkar2btm2Gsm/Prkar2b+
involves: C57BL/6 MGI:3773449
cx19
Ay-Jkn/A
Mc1re/Mc1re
Tg(MC1R)1Jkn/0
involves: C57BL/6Ha * C57BL/6N MGI:3805939
cx20
Ay-Jkn/A
Mc1re/Mc1re
involves: C57BL/6Ha * C57BL/6N MGI:3805938
cx21
Avy/A
Smarca5MommeD4/Smarca5+
involves: C57BL/6J * FVB/NJ MGI:3607160
cx22
Avy/A
Smchd1MommeD1/Smchd1+
involves: C57BL/6J * FVB/NJ MGI:3607153
cx23
Avy/A
Dnmt1MommeD2/Dnmt1+
involves: C57BL/6J * FVB/NJ MGI:3607157
cx24
A/A
Dkd/Dkd
LPT;C3-Dkd/GrsrJ MGI:3803320
cx25
A/A
Mc1rE-tob/Mc1r+
M. m. domesticus poschiavinus MGI:5629972
cx26
A/A
Mc1rE-tob/Mc1rE-tob
M. m. domesticus poschiavinus MGI:3687979
cx27
A/?
Lystbg/Lystbg
Tyrp1+/?
Not Specified MGI:4453314
cx28
A/A
Tyrc-ch/Tyrc-ch
Not Specified MGI:5460836
cx29
A/A
Hps6ru/Hps6ru
Not Specified MGI:5466746
cx30
A/a
Tyrp1B-lt/Tyrp1B-lt
Not Specified MGI:3795188
cx31
A/A
U/U
Not Specified MGI:3844566
cx32
A/?
Lystbg/Lystbg
Tyrp1b/Tyrp1b
Not Specified MGI:2654822
cx33
at/A
As/As+
Not Specified MGI:4418457


Genotype
MGI:5460857
hm1
Allelic
Composition
A/A
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype

pigmentation
N
• wild-type coat color created by hairs with a black base, yellow subterminal band, and black tip




Genotype
MGI:4453172
ht2
Allelic
Composition
Ahvy/A
Genetic
Background
B6.C3-Bpifa2a Ahvy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Ahvy mutation (1 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• Background Sensitivity: amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is variably increased or decreased compared with a wild-type agouti pattern resulting in a range of coat color from creamy yellow to black
• this coat pigmentation is seen when yellow pigment (phaeomelanin) is minimal; the coat resembles non-agouti black
• a creamy yellow coat color predominates but black striping or patches are seen on the back and/or belly
• black striping or patches are frequently seen on the back and/or belly; the remainder of the coat is creamy yellow

integument
• Background Sensitivity: amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is variably increased or decreased compared with a wild-type agouti pattern resulting in a range of coat color from creamy yellow to black
• this coat pigmentation is seen when yellow pigment (phaeomelanin) is minimal; the coat resembles non-agouti black
• a creamy yellow coat color predominates but black striping or patches are seen on the back and/or belly
• black striping or patches are frequently seen on the back and/or belly; the remainder of the coat is creamy yellow




Genotype
MGI:3821616
ht3
Allelic
Composition
Aiy/A
Genetic
Background
C3H/HeJ-Aiy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Aiy mutation (1 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• heterozygotes and homozygotes are indistinguishable
• color ranges from very sooty yellow to indistinguishable from wild-type agouti
• ventrum is slightly lighter than dorsal pigmentation
• mottling is variable

growth/size/body
• become obese as adults

integument
• heterozygotes and homozygotes are indistinguishable
• color ranges from very sooty yellow to indistinguishable from wild-type agouti
• ventrum is slightly lighter than dorsal pigmentation
• mottling is variable

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:30922




Genotype
MGI:2181396
ht4
Allelic
Composition
Aw-47J/A
Genetic
Background
C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Aw-47J mutation (0 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:5471527
ht5
Allelic
Composition
A/atl
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
atl mutation (0 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• pale colored belly fur

pigmentation
• pale colored belly fur




Genotype
MGI:5086113
ht6
Allelic
Composition
Ay/A
Genetic
Background
involves: C3H/HeJ * C57BL/6J-Ay/a
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument

pigmentation




Genotype
MGI:3773447
ht7
Allelic
Composition
Ay/A
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• female mice have a 6-fold gain in weight of BAT compared to littermate controls
• female mice have almost a 7-fold gain in weight of fat pad
• female mice have a greater than 6-fold gain in weight of fat pad
• female mice have almost a 6-fold gain in weight of fat pad
• female mice have almost a 4-fold gain in percentage of body fat compared to littermate controls
• male mice have almost a 1.8-fold gain in percentage of body fat compared to littermate controls

behavior/neurological
• 18 week old mice eat about 1.4 times more food during a 7 day period compared to wild-type controls
• the locomotor activity of mice is about half that of wild-type mice

growth/size/body
• by 23 weeks of age, female mice have almost double the weight compared to their wild-type littermate controls
• female but not male mice have a significant 5% increase in their body length
• mice gain weight at a greater rate than littermate controls starting at six weeks of age

homeostasis/metabolism
• circulating levels of leptin are over 12-fold higher compared to littermate controls

liver/biliary system
• female mice have almost a 2-fold gain in weight of the liver

pigmentation
• mice have a yellow coat color

integument
• mice have a yellow coat color

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:131039




Genotype
MGI:3805937
ht8
Allelic
Composition
Ay-Jkn/A
Genetic
Background
involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Ay-Jkn mutation (0 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• mice have a pale yellow coat color
• the color is paler than observed in Mc1re homozygotes

integument
• mice have a pale yellow coat color
• the color is paler than observed in Mc1re homozygotes




Genotype
MGI:4367212
ht9
Allelic
Composition
A/atwp
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
atwp mutation (0 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• dorsum is agouti, ventrum white
• this allele is recessive on the dorsum, dominant on the ventrum
• ventral coat color is white, identical to the color and pattern of a Aw/- mouse
• this allele is dominant to A on the ventrum

integument
• dorsum is agouti, ventrum white
• this allele is recessive on the dorsum, dominant on the ventrum
• ventral coat color is white, identical to the color and pattern of a Aw/- mouse
• this allele is dominant to A on the ventrum




Genotype
MGI:5766498
cx10
Allelic
Composition
A/a
In(11Trp53;11Wnt3)8Brd/+
Genetic
Background
either: (involves: 129S7/SvEvBrd * C57BL/6Brd) or (involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6Brd) or (involves: 129S5/SvEvBrd * C57BL/6Brd * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
A mutation (23 available); any a mutation (364 available)
In(11Trp53;11Wnt3)8Brd mutation (2 available); any In(11Trp53;11Wnt3)8Brd mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored ears due to the Krt14-A transgene in the Wnt3 locus.

growth/size/body
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored ears due to the Krt14-A transgene in the Wnt3 locus.

hearing/vestibular/ear
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored ears due to the Krt14-A transgene in the Wnt3 locus.

integument
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored ears due to the Krt14-A transgene in the Wnt3 locus.
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored tails due to the Krt14-A transgene in the Wnt3 locus.

limbs/digits/tail
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored tails due to the Krt14-A transgene in the Wnt3 locus.

pigmentation
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored ears due to the Krt14-A transgene in the Wnt3 locus.
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored tails due to the Krt14-A transgene in the Wnt3 locus.




Genotype
MGI:4418456
cx11
Allelic
Composition
As/As
A/A
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
As mutation (1 available); any As mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• amount of yellow pigment produced by an agouti genotype is reduced and coat is darker than expected
• the normally yellow pinna hairs for all agouti alleles except ae are black (or brown on a homozygous brown background)

integument
• amount of yellow pigment produced by an agouti genotype is reduced and coat is darker than expected
• the normally yellow pinna hairs for all agouti alleles except ae are black (or brown on a homozygous brown background)




Genotype
MGI:3805940
cx12
Allelic
Composition
a/A
Pomctm1Sora/Pomctm1Sora
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
A mutation (23 available); any a mutation (364 available)
Pomctm1Sora mutation (0 available); any Pomc mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• mice have a slightly more yellow coat than agouti controls
• the phaeomelanin to total melanin ratio is higher (0.30) than in agouti controls (0.19)

integument
• mice have a slightly more yellow coat than agouti controls
• the phaeomelanin to total melanin ratio is higher (0.30) than in agouti controls (0.19)




Genotype
MGI:3805942
cx13
Allelic
Composition
a/A
Mc1re/Mc1re
Pomctm1Sora/Pomctm1Sora
Tg(MC1R)1Jkn/?
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6Ha
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
A mutation (23 available); any a mutation (364 available)
Mc1re mutation (6 available); any Mc1r mutation (25 available)
Pomctm1Sora mutation (0 available); any Pomc mutation (9 available)
Tg(MC1R)1Jkn mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• mice have a much more yellow coat than agouti controls
• the phaeomelanin to total melanin ratio is higher (2.00) than in agouti controls (0.19)

integument
• mice have a much more yellow coat than agouti controls
• the phaeomelanin to total melanin ratio is higher (2.00) than in agouti controls (0.19)




Genotype
MGI:3027715
cx14
Allelic
Composition
A/?
DctSlt-lt/DctSlt-lt
Genetic
Background
involves: C3H/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
DctSlt-lt mutation (1 available); any Dct mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• on an agouti background, the fur of homozygous DctSlt-lt mice appears yellowish brown.

integument
• on an agouti background, the fur of homozygous DctSlt-lt mice appears yellowish brown.




Genotype
MGI:3576263
cx15
Allelic
Composition
A/?
DctSlt-lt/Dct+
Genetic
Background
involves: C3H/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
DctSlt-lt mutation (1 available); any Dct mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• on an agouti background, the coat color of mice heterozygous for DctSlt-lt is light agouti.

integument
• on an agouti background, the coat color of mice heterozygous for DctSlt-lt is light agouti.




Genotype
MGI:5605663
cx16
Allelic
Composition
Ay/A
Pepddal/Pepddal
Genetic
Background
involves: C3H/HeJ * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Pepddal mutation (1 available); any Pepd mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• dark-like homozygotes heterozygous for yellow have much darker dorsal hair than mice heterozygous for both mutations, placing dark-like downstream of agouti transcription

pigmentation
• dark-like homozygotes heterozygous for yellow have much darker dorsal hair than mice heterozygous for both mutations, placing dark-like downstream of agouti transcription

growth/size/body
• mice heterozygous for yellow are obese and longer than normal to the same degree regardless of being wild-type or homozygous for dark-like




Genotype
MGI:3773448
cx17
Allelic
Composition
Ay/A
Prkar2btm2Gsm/Prkar2btm2Gsm
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Prkar2btm2Gsm mutation (1 available); any Prkar2b mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• female mice have a 2-fold gain in mg of BAT compared to littermate controls
• female mice have almost a 2-fold increase in fat pad weight compared to wild-type controls
• female mice have about a 2-fold increase in fat pad weight compared to wild-type controls
• female mice have about a 2-fold increase in fat pad weight compared to wild-type controls
• female and male mice have a 1.6-fold gain in percentage of body fat compared to littermate controls

behavior/neurological
N
• food consumption and circulating levels of leptin are close to wild-type levels, which is significantly less compared to mice with only the Ay mutant allele
• locomotor activity is about 1.5-fold higher compared to wild-type control mice

growth/size/body
N
• mean body weight and length of 20-23 week old mice is similar to wild-type littermate controls and is less than is observed in mice with only the Ay mutant allele
• weight and percentage of body fat in female mice is higher than in wild-type mice but is significantly lower than is observed in mice with only the Ay mutant allele
• male but not female mice gain weight at a greater rate than littermate controls starting at six weeks of age
• rate of weight gain in male mice is significantly less than in Ay heterozygotes

pigmentation
• mice have a yellow coat color

integument
• mice have a yellow coat color




Genotype
MGI:3773449
cx18
Allelic
Composition
Ay/A
Prkar2btm2Gsm/Prkar2b+
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Prkar2btm2Gsm mutation (1 available); any Prkar2b mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• mice have increased percentage of body fat but is 10% less than what is observed in Ay heterozygotes

behavior/neurological
• mice have a higher food consumption but is about 10% less than the amount Ay heterozygotes consume

growth/size/body
• mice have increased rate of weight growth compared to wild-type mice but significantly less than in Ay heterozygotes




Genotype
MGI:3805939
cx19
Allelic
Composition
Ay-Jkn/A
Mc1re/Mc1re
Tg(MC1R)1Jkn/0
Genetic
Background
involves: C57BL/6Ha * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Ay-Jkn mutation (0 available); any a mutation (364 available)
Mc1re mutation (6 available); any Mc1r mutation (25 available)
Tg(MC1R)1Jkn mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• mice have a pale yellow coat color
• the yellow color is darker than what is observed in Ay-Jkn heterozygotes

integument
• mice have a pale yellow coat color
• the yellow color is darker than what is observed in Ay-Jkn heterozygotes




Genotype
MGI:3805938
cx20
Allelic
Composition
Ay-Jkn/A
Mc1re/Mc1re
Genetic
Background
involves: C57BL/6Ha * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Ay-Jkn mutation (0 available); any a mutation (364 available)
Mc1re mutation (6 available); any Mc1r mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• mice have a pale yellow coat color
• the yellow color is darker than what is observed in Ay-Jknheterozygotes

integument
• mice have a pale yellow coat color
• the yellow color is darker than what is observed in Ay-Jknheterozygotes




Genotype
MGI:3607160
cx21
Allelic
Composition
Avy/A
Smarca5MommeD4/Smarca5+
Genetic
Background
involves: C57BL/6J * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Avy mutation (7 available); any a mutation (364 available)
Smarca5MommeD4 mutation (0 available); any Smarca5 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• when a MommeD4 sire is mated to a yellow dam offspring with the MommeD4 allele are more likely to be mottled

integument
• when a MommeD4 sire is mated to a yellow dam offspring with the MommeD4 allele are more likely to be mottled




Genotype
MGI:3607153
cx22
Allelic
Composition
Avy/A
Smchd1MommeD1/Smchd1+
Genetic
Background
involves: C57BL/6J * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Avy mutation (7 available); any a mutation (364 available)
Smchd1MommeD1 mutation (0 available); any Smchd1 mutation (78 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• more female pups with yellow coat color are produced when a MommeD1 sire is crossed with a psuedoagouti dam but not when the reciprocal cross is made

integument
• more female pups with yellow coat color are produced when a MommeD1 sire is crossed with a psuedoagouti dam but not when the reciprocal cross is made




Genotype
MGI:3607157
cx23
Allelic
Composition
Avy/A
Dnmt1MommeD2/Dnmt1+
Genetic
Background
involves: C57BL/6J * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Avy mutation (7 available); any a mutation (364 available)
Dnmt1MommeD2 mutation (0 available); any Dnmt1 mutation (70 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• more female pups with yellow coat color are produced when a MommeD1 dam is crossed with a psuedoagouti sire but not when the reciprocal cross is made

integument
• more female pups with yellow coat color are produced when a MommeD1 dam is crossed with a psuedoagouti sire but not when the reciprocal cross is made




Genotype
MGI:3803320
cx24
Allelic
Composition
A/A
Dkd/Dkd
Genetic
Background
LPT;C3-Dkd/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Dkd mutation (1 available); any Dkd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Phenotype of Dkd/Dkd mouse

pigmentation
• a darkened dorsal stripe if seen when the first coat comes in

hearing/vestibular/ear
N
• ABR assessment at 4 weeks of age is normal

vision/eye
N
• eyes are normal by ophthalmoscopic examination at 4 weeks of age

integument
• a darkened dorsal stripe if seen when the first coat comes in




Genotype
MGI:5629972
cx25
Allelic
Composition
A/A
Mc1rE-tob/Mc1r+
Genetic
Background
M. m. domesticus poschiavinus
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Mc1rE-tob mutation (4 available); any Mc1r mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• Mc1rE-tob influences the expression of agouti
• the color is difficult to distinguish from non-agouti black before 8 weeks of age when some agouti hairs appear on the flanks; the back remains darkened
• Mc1rE-tob/Mc1re A/a mice have a darkened back

pigmentation
• Mc1rE-tob influences the expression of agouti
• the color is difficult to distinguish from non-agouti black before 8 weeks of age when some agouti hairs appear on the flanks; the back remains darkened
• Mc1rE-tob/Mc1re A/a mice have a darkened back




Genotype
MGI:3687979
cx26
Allelic
Composition
A/A
Mc1rE-tob/Mc1rE-tob
Genetic
Background
M. m. domesticus poschiavinus
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Mc1rE-tob mutation (4 available); any Mc1r mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• Mc1rE-tob influences the expression of agouti
• the color is difficult to distinguish from non-agouti black before 8 weeks of age when agouti hairs appear on the flanks; the back remains darkened
• Mc1rE-tob/Mc1re mice that are also homozygous non-agouti are black because Mc1rE-tob only affects the expression of agouti

integument
• Mc1rE-tob influences the expression of agouti
• the color is difficult to distinguish from non-agouti black before 8 weeks of age when agouti hairs appear on the flanks; the back remains darkened
• Mc1rE-tob/Mc1re mice that are also homozygous non-agouti are black because Mc1rE-tob only affects the expression of agouti




Genotype
MGI:4453314
cx27
Allelic
Composition
A/?
Lystbg/Lystbg
Tyrp1+/?
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Lystbg mutation (5 available); any Lyst mutation (109 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls
• on an agouti black (A-B-) background, mice exhibit a lighter coat color than wild-type controls, particularly at the base of the hairs
• basal dilution is first noted at ~15 days of age, is somewhat variable, and tends to become darker in older mice
• on an agouti black (A-B-) background, mutant dorsal hairs have a yellow subterminal band, a dark grey middle portion, and usually a very light grey base
• basal dilution is first noted at ~15 days of age, is somewhat variable, and tends to become darker in older mice
• on an agouti black (A-B-) background, mice exhibit reduced tail pigmentation relative to wild-type controls
• on an agouti black (A-B-) background, the eye pigmentation of mice is only slight at birth but varies from ruby to almost black in adults

vision/eye
• on an agouti black (A-B-) background, the eye pigmentation of mice is only slight at birth but varies from ruby to almost black in adults

limbs/digits/tail
• on an agouti black (A-B-) background, mice exhibit reduced tail pigmentation relative to wild-type controls

craniofacial
• on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls

hearing/vestibular/ear
• on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls

integument
• on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls
• on an agouti black (A-B-) background, mice exhibit a lighter coat color than wild-type controls, particularly at the base of the hairs
• basal dilution is first noted at ~15 days of age, is somewhat variable, and tends to become darker in older mice
• on an agouti black (A-B-) background, mutant dorsal hairs have a yellow subterminal band, a dark grey middle portion, and usually a very light grey base
• basal dilution is first noted at ~15 days of age, is somewhat variable, and tends to become darker in older mice
• on an agouti black (A-B-) background, mice exhibit reduced tail pigmentation relative to wild-type controls

growth/size/body
• on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls




Genotype
MGI:5460836
cx28
Allelic
Composition
A/A
Tyrc-ch/Tyrc-ch
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Tyrc-ch mutation (88 available); any Tyr mutation (366 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• the contrasted effects of this genotype on eumelanin and phaeomelanin produces a grizzled color pattern or chinchilla effect
• reduced melanin content alters the wild-type agouti color to gray
• in this genotype yellow pigment in the hair shaft is reduced or absent

pigmentation
• reduced melanin content alters the wild-type agouti color to gray
• in this genotype yellow pigment in the hair shaft is reduced or absent




Genotype
MGI:5466746
cx29
Allelic
Composition
A/A
Hps6ru/Hps6ru
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Hps6ru mutation (6 available); any Hps6 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• the black pigment in the coat is reduced on this background to dark slate color but the yellow pigmented agouti band at the hair tips is barely reduced in intensity so mice of this genotype are a slightly lighter agouti

pigmentation
• the black pigment in the coat is reduced on this background to dark slate color but the yellow pigmented agouti band at the hair tips is barely reduced in intensity so mice of this genotype are a slightly lighter agouti




Genotype
MGI:3795188
cx30
Allelic
Composition
A/a
Tyrp1B-lt/Tyrp1B-lt
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
A mutation (23 available); any a mutation (364 available)
Tyrp1B-lt mutation (4 available); any Tyrp1 mutation (164 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• more dilute than mice heterozygous for light due to a further diminution in the eumelanic pigment, but there is no alteration in the yellow bands of the hair shaft

integument
• more dilute than mice heterozygous for light due to a further diminution in the eumelanic pigment, but there is no alteration in the yellow bands of the hair shaft




Genotype
MGI:3844566
cx31
Allelic
Composition
A/A
U/U
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
U mutation (2 available); any U mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• U modifies agouti dominance: when U is homozygous there is a marked darkening in A/A mice; when U is heterozygotes the darkening is somewhat less (J:280)
• the coat is darkened relative to the number of copies of U and a as follows: A/a; U/U > A/a; U/u = A/A; U/U > A/A; U/u = A/a; u/u > A/A; u/u (J:78801)

integument
• U modifies agouti dominance: when U is homozygous there is a marked darkening in A/A mice; when U is heterozygotes the darkening is somewhat less (J:280)
• the coat is darkened relative to the number of copies of U and a as follows: A/a; U/U > A/a; U/u = A/A; U/U > A/A; U/u = A/a; u/u > A/A; u/u (J:78801)




Genotype
MGI:2654822
cx32
Allelic
Composition
A/?
Lystbg/Lystbg
Tyrp1b/Tyrp1b
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Lystbg mutation (5 available); any Lyst mutation (109 available)
Tyrp1b mutation (97 available); any Tyrp1 mutation (164 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• on an agouti brown (A-bb) background, beige mice exhibit an overall cafe-au-lait coat color
• Background Sensitivity: the relatively greater dilution effect noted on basal hair is not as pronounced in brown beige as in black beige mice
• Background Sensitivity: on an agouti brown (A-bb) background, newborn beige mice exhibit lighter eyes than on an agouti black (A-B-) background

vision/eye
• Background Sensitivity: on an agouti brown (A-bb) background, newborn beige mice exhibit lighter eyes than on an agouti black (A-B-) background

integument
• on an agouti brown (A-bb) background, beige mice exhibit an overall cafe-au-lait coat color
• Background Sensitivity: the relatively greater dilution effect noted on basal hair is not as pronounced in brown beige as in black beige mice




Genotype
MGI:4418457
cx33
Allelic
Composition
at/A
As/As+
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
As mutation (1 available); any As mutation (1 available)
at mutation (12 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• only the agouti allele on the same chromosome as the As allele is affected
• the expected cream belly is not seen for this genotype; the mouse looks normal agouti

integument
• only the agouti allele on the same chromosome as the As allele is affected
• the expected cream belly is not seen for this genotype; the mouse looks normal agouti





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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory