• wild-type coat color created by hairs with a black base, yellow subterminal band, and black tip (J:36414)

• Background Sensitivity: amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is variably increased or decreased compared with a wild-type agouti pattern resulting in a range of coat color from creamy yellow to black

• this coat pigmentation is seen when yellow pigment (phaeomelanin) is minimal; the coat resembles non-agouti black

• black striping or patches are frequently seen on the back and/or belly; the remainder of the coat is creamy yellow

• a creamy yellow coat color predominates but black striping or patches are seen on the back and/or belly

• Background Sensitivity: amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is variably increased or decreased compared with a wild-type agouti pattern resulting in a range of coat color from creamy yellow to black

• this coat pigmentation is seen when yellow pigment (phaeomelanin) is minimal; the coat resembles non-agouti black

• black striping or patches are frequently seen on the back and/or belly; the remainder of the coat is creamy yellow

• a creamy yellow coat color predominates but black striping or patches are seen on the back and/or belly

• heterozygotes and homozygotes are indistinguishable

• mottling is variable

• color ranges from very sooty yellow to indistinguishable from wild-type agouti

• ventrum is slightly lighter than dorsal pigmentation

• become obese as adults

• heterozygotes and homozygotes are indistinguishable

• mottling is variable

• color ranges from very sooty yellow to indistinguishable from wild-type agouti

• ventrum is slightly lighter than dorsal pigmentation

• pale colored belly fur

• pale colored belly fur

• female mice have a 6-fold gain in weight of BAT compared to littermate controls

• female mice have almost a 4-fold gain in percentage of body fat compared to littermate controls

• male mice have almost a 1.8-fold gain in percentage of body fat compared to littermate controls

• female mice have almost a 7-fold gain in weight of fat pad

• female mice have a greater than 6-fold gain in weight of fat pad

• female mice have almost a 6-fold gain in weight of fat pad

• 18 week old mice eat about 1.4 times more food during a 7 day period compared to wild-type controls

• the locomotor activity of mice is about half that of wild-type mice

• female but not male mice have a significant 5% increase in their body length

• mice gain weight at a greater rate than littermate controls starting at six weeks of age

• by 23 weeks of age, female mice have almost double the weight compared to their wild-type littermate controls

• circulating levels of leptin are over 12-fold higher compared to littermate controls

• female mice have almost a 2-fold gain in weight of the liver

• mice have a yellow coat color

• mice have a yellow coat color

• mice have a pale yellow coat color

• the color is paler than observed in Mc1r^e homozygotes

• mice have a pale yellow coat color

• the color is paler than observed in Mc1r^e homozygotes

• dorsum is agouti, ventrum white

• this allele is recessive on the dorsum, dominant on the ventrum

• ventral coat color is white, identical to the color and pattern of a A^w/- mouse

• this allele is dominant to A on the ventrum

• dorsum is agouti, ventrum white

• this allele is recessive on the dorsum, dominant on the ventrum

• ventral coat color is white, identical to the color and pattern of a A^w/- mouse

• this allele is dominant to A on the ventrum

• amount of yellow pigment produced by an agouti genotype is reduced and coat is darker than expected

• the normally yellow pinna hairs for all agouti alleles except a^e are black (or brown on a homozygous brown background)

• amount of yellow pigment produced by an agouti genotype is reduced and coat is darker than expected

• the normally yellow pinna hairs for all agouti alleles except a^e are black (or brown on a homozygous brown background)

• the phaeomelanin to total melanin ratio is higher (0.30) than in agouti controls (0.19)

• mice have a slightly more yellow coat than agouti controls

• the phaeomelanin to total melanin ratio is higher (0.30) than in agouti controls (0.19)

• mice have a slightly more yellow coat than agouti controls

• the phaeomelanin to total melanin ratio is higher (2.00) than in agouti controls (0.19)

• mice have a much more yellow coat than agouti controls

• the phaeomelanin to total melanin ratio is higher (2.00) than in agouti controls (0.19)

• mice have a much more yellow coat than agouti controls

• female mice have a 2-fold gain in mg of BAT compared to littermate controls

• female and male mice have a 1.6-fold gain in percentage of body fat compared to littermate controls

• female mice have almost a 2-fold increase in fat pad weight compared to wild-type controls

• female mice have about a 2-fold increase in fat pad weight compared to wild-type controls

• female mice have about a 2-fold increase in fat pad weight compared to wild-type controls

• food consumption and circulating levels of leptin are close to wild-type levels, which is significantly less compared to mice with only the A^y mutant allele (J:131039)

• locomotor activity is about 1.5-fold higher compared to wild-type control mice

• mean body weight and length of 20-23 week old mice is similar to wild-type littermate controls and is less than is observed in mice with only the A^y mutant allele (J:131039)

• weight and percentage of body fat in female mice is higher than in wild-type mice but is significantly lower than is observed in mice with only the A^y mutant allele (J:131039)

• male but not female mice gain weight at a greater rate than littermate controls starting at six weeks of age

• rate of weight gain in male mice is significantly less than in A^y heterozygotes

• mice have a yellow coat color

• mice have a yellow coat color

• mice have increased percentage of body fat but is 10% less than what is observed in A^y heterozygotes

• mice have a higher food consumption but is about 10% less than the amount A^y heterozygotes consume

• mice have increased rate of weight growth compared to wild-type mice but significantly less than in A^y heterozygotes

• mice have a pale yellow coat color

• the yellow color is darker than what is observed in A^y-Jknheterozygotes

• mice have a pale yellow coat color

• the yellow color is darker than what is observed in A^y-Jknheterozygotes

• mice have a pale yellow coat color

• the yellow color is darker than what is observed in A^y-Jkn heterozygotes

• mice have a pale yellow coat color

• the yellow color is darker than what is observed in A^y-Jkn heterozygotes

• more female pups with yellow coat color are produced when a MommeD1 sire is crossed with a psuedoagouti dam but not when the reciprocal cross is made

• more female pups with yellow coat color are produced when a MommeD1 sire is crossed with a psuedoagouti dam but not when the reciprocal cross is made

• more female pups with yellow coat color are produced when a MommeD1 dam is crossed with a psuedoagouti sire but not when the reciprocal cross is made

• more female pups with yellow coat color are produced when a MommeD1 dam is crossed with a psuedoagouti sire but not when the reciprocal cross is made

• when a MommeD4 sire is mated to a yellow dam offspring with the MommeD4 allele are more likely to be mottled

• when a MommeD4 sire is mated to a yellow dam offspring with the MommeD4 allele are more likely to be mottled

• a darkened dorsal stripe if seen when the first coat comes in

• ABR assessment at 4 weeks of age is normal (J:137334)

• eyes are normal by ophthalmoscopic examination at 4 weeks of age (J:137334)

• a darkened dorsal stripe if seen when the first coat comes in

• on an agouti brown (A-bb) background, beige mice exhibit an overall cafe-au-lait coat color

• Background Sensitivity: the relatively greater dilution effect noted on basal hair is not as pronounced in brown beige as in black beige mice

• Background Sensitivity: on an agouti brown (A-bb) background, newborn beige mice exhibit lighter eyes than on an agouti black (A-B-) background

• Background Sensitivity: on an agouti brown (A-bb) background, newborn beige mice exhibit lighter eyes than on an agouti black (A-B-) background

• on an agouti brown (A-bb) background, beige mice exhibit an overall cafe-au-lait coat color

• Background Sensitivity: the relatively greater dilution effect noted on basal hair is not as pronounced in brown beige as in black beige mice

• more dilute than mice heterozygous for light due to a further diminution in the eumelanic pigment, but there is no alteration in the yellow bands of the hair shaft

• more dilute than mice heterozygous for light due to a further diminution in the eumelanic pigment, but there is no alteration in the yellow bands of the hair shaft

• U modifies agouti dominance: when U is homozygous there is a marked darkening in A/A mice; when U is heterozygotes the darkening is somewhat less (J:280)

• the coat is darkened relative to the number of copies of U and a as follows: A/a; U/U > A/a; U/u = A/A; U/U > A/A; U/u = A/a; u/u > A/A; u/u (J:78801)

• U modifies agouti dominance: when U is homozygous there is a marked darkening in A/A mice; when U is heterozygotes the darkening is somewhat less (J:280)

• the coat is darkened relative to the number of copies of U and a as follows: A/a; U/U > A/a; U/u = A/A; U/U > A/A; U/u = A/a; u/u > A/A; u/u (J:78801)

• only the agouti allele on the same chromosome as the A^s allele is affected

• the expected cream belly is not seen for this genotype; the mouse looks normal agouti

• only the agouti allele on the same chromosome as the A^s allele is affected

• the expected cream belly is not seen for this genotype; the mouse looks normal agouti

• on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls

• on an agouti black (A-B-) background, mice exhibit a lighter coat color than wild-type controls, particularly at the base of the hairs

• basal dilution is first noted at ~15 days of age, is somewhat variable, and tends to become darker in older mice

• on an agouti black (A-B-) background, mutant dorsal hairs have a yellow subterminal band, a dark grey middle portion, and usually a very light grey base

• basal dilution is first noted at ~15 days of age, is somewhat variable, and tends to become darker in older mice

• on an agouti black (A-B-) background, mice exhibit reduced tail pigmentation relative to wild-type controls

• on an agouti black (A-B-) background, the eye pigmentation of mice is only slight at birth but varies from ruby to almost black in adults

• on an agouti black (A-B-) background, the eye pigmentation of mice is only slight at birth but varies from ruby to almost black in adults

• on an agouti black (A-B-) background, mice exhibit reduced tail pigmentation relative to wild-type controls

• on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls

• on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls

• on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls

• on an agouti black (A-B-) background, mice exhibit a lighter coat color than wild-type controls, particularly at the base of the hairs

• basal dilution is first noted at ~15 days of age, is somewhat variable, and tends to become darker in older mice

• on an agouti black (A-B-) background, mutant dorsal hairs have a yellow subterminal band, a dark grey middle portion, and usually a very light grey base

• basal dilution is first noted at ~15 days of age, is somewhat variable, and tends to become darker in older mice

• on an agouti black (A-B-) background, mice exhibit reduced tail pigmentation relative to wild-type controls

• the contrasted effects of this genotype on eumelanin and phaeomelanin produces a grizzled color pattern or chinchilla effect

• reduced melanin content alters the wild-type agouti color to gray

• in this genotype yellow pigment in the hair shaft is reduced or absent

• reduced melanin content alters the wild-type agouti color to gray

• in this genotype yellow pigment in the hair shaft is reduced or absent

• the black pigment in the coat is reduced on this background to dark slate color but the yellow pigmented agouti band at the hair tips is barely reduced in intensity so mice of this genotype are a slightly lighter agouti

• the black pigment in the coat is reduced on this background to dark slate color but the yellow pigmented agouti band at the hair tips is barely reduced in intensity so mice of this genotype are a slightly lighter agouti