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Arid5a Gene Detail
Summary
  • Symbol
    Arid5a
  • Name
    AT-rich interaction domain 5A
  • Synonyms
    D430024K22Rik, Mrf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443039
    NCBI Gene: 214855
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:36346814-36363110 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 15.20 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    495 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443039
 protein coding gene Chr1:36346814-36363117 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015920
 protein coding gene Chr1:34830417-34846728 (+)
A/J MGP_AJ_G0015904
 protein coding gene Chr1:33900088-33916370 (+)
AKR/J MGP_AKRJ_G0015859
 protein coding gene Chr1:34386296-34402590 (+)
BALB/cJ MGP_BALBcJ_G0015858
 protein coding gene Chr1:33592182-33608486 (+)
C3H/HeJ MGP_C3HHeJ_G0015691
 protein coding gene Chr1:34565416-34581699 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016311
 protein coding gene Chr1:36408469-36425844 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014033
 protein coding gene Chr1:30954262-30970696 (+)
CAST/EiJ MGP_CASTEiJ_G0015272
 protein coding gene Chr1:34456969-34473497 (+)
CBA/J MGP_CBAJ_G0015663
 protein coding gene Chr1:37372317-37391287 (+)
DBA/2J MGP_DBA2J_G0015764
 protein coding gene Chr1:33238768-33255062 (+)
FVB/NJ MGP_FVBNJ_G0015766
 protein coding gene Chr1:32755759-32772054 (+)
LP/J MGP_LPJ_G0015834
 protein coding gene Chr1:35200035-35216853 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015786
 protein coding gene Chr1:39607301-39623592 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016358
 protein coding gene Chr1:34405119-34421413 (+)
PWK/PhJ MGP_PWKPhJ_G0015055
 protein coding gene Chr1:32983902-33000129 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014837
 protein coding gene Chr1:34362980-34379269 (+)
WSB/EiJ MGP_WSBEiJ_G0015334
 protein coding gene Chr1:34362423-34378714 (+)



Homology
more
  • Human Ortholog
    ARID5A, AT-rich interaction domain 5A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARID5A, AT-rich interaction domain 5A
  • Synonyms
    MRF-1, MRF1, RP11-363D14
  • Links
    NCBI Gene ID: 10865
    neXtProt AC: NX_Q03989
    UniProt: Q03989

  • Chr Location
    2q11.2; chr2:96536743-96552638 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced serum interleukin-6 and tumor necrosis factor levels following LPS treatment, and decreased susceptibility to experimental autoimmune encephalomyelitis along with decreased T-helper 17 cell number and increased IFN-gamma producing T cell number.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    844
  • Tissues
    101
  • cDNA Data
    58
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037447 Ensembl Gene Model | MGI Sequence Detail 16297 C57BL/6J ±  kb
    transcript ENSMUST00000115031 Ensembl | MGI Sequence Detail 3002 Not Applicable  
    polypeptide ENSMUSP00000110683 Ensembl | MGI Sequence Detail 684 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      cDNA 58
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:353339 Butts JC, et al., A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain. Dev Cell. 2024 Aug 19;59(16):2171-2188.e7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory