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Chrna7 Gene Detail
Summary
  • Symbol
    Chrna7
  • Name
    cholinergic receptor, nicotinic, alpha polypeptide 7
  • Synonyms
    Acra7, alpha7, alpha7-nAChR, alpha7 nicotinic receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:99779
    NCBI Gene: 11441
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:62748440-62862274 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 34.47 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1397 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99779
 protein coding gene Chr7:62748440-62862317 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032330
 protein coding gene Chr7:64149558-64269492 (-)
A/J MGP_AJ_G0032309
 protein coding gene Chr7:62963560-63078210 (-)
AKR/J MGP_AKRJ_G0032245
 protein coding gene Chr7:64298814-64419853 (-)
BALB/cJ MGP_BALBcJ_G0032321
 protein coding gene Chr7:62652654-62767186 (-)
C3H/HeJ MGP_C3HHeJ_G0032034
 protein coding gene Chr7:64937750-65059404 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032814
 protein coding gene Chr7:66952003-67089181 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029821
 protein coding gene Chr7:65971484-66091612 (-)
CAST/EiJ MGP_CASTEiJ_G0031363
 protein coding gene Chr7:55622982-55741646 (-)
CBA/J MGP_CBAJ_G0032000
 protein coding gene Chr7:69097447-69224083 (-)
DBA/2J MGP_DBA2J_G0032156
 protein coding gene Chr7:61736147-61853252 (-)
FVB/NJ MGP_FVBNJ_G0032110
 protein coding gene Chr7:61821864-61936968 (-)
LP/J MGP_LPJ_G0032236
 protein coding gene Chr7:65403228-65523535 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032147
 protein coding gene Chr7:69416537-69547167 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032831
 protein coding gene Chr7:63547780-63670997 (-)
PWK/PhJ MGP_PWKPhJ_G0031083
 protein coding gene Chr7:54729289-54848898 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030924
 protein coding gene Chr7:50684596-50807348 (-)
WSB/EiJ MGP_WSBEiJ_G0031481
 protein coding gene Chr7:63938253-64057084 (-)



Homology
more
  • Human Ortholog
    CHRFAM7A, CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHRFAM7A, CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion
  • Synonyms
    CHRNA7, CHRNA7-DR1, D-10, NACHRA7
  • Links
    NCBI Gene ID: 89832
    neXtProt AC: NX_P36544, NX_Q494W8
    UniProt: Q494W8

  • Chr Location
    15q13.2; chr15:30360566-30393900 (-)  GRCh38
  • Human Ortholog
    CHRNA7, cholinergic receptor nicotinic alpha 7 subunit
  • Synonyms
    CHRNA7-2, NACHRA7
  • Links
    NCBI Gene ID: 1139
    neXtProt AC: NX_P36544
    UniProt: P36544

  • Chr Location
    15q13.3; chr15:31923438-32173018 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Chrna7 mouse models; 6 with human CHRNA7 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 4 alleles in 9 genetic backgrounds
    28 phenotypes from multigenic genotypes
    236 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice lack hippocampal fast nicotinic currents but show nicotine-induced seizures as well as altered anxiety behavior, fertility defects, airway basal cell hyperplasia. and higher TNF sythesis when endotoxemic. Newborns homozygous for a knock-in allele die with increased neuron apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    123
  • GO References
    40
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    894
  • Tissues
    90
  • cDNA Data
    17
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11441 NCBI Gene Model | MGI Sequence Detail 113835 C57BL/6J ±  kb
    transcript NM_007390 RefSeq | MGI Sequence Detail 2091 ZRU/MplStud  
    polypeptide P49582 UniProt | EBI | MGI Sequence Detail 502 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000005460 neuronal acetylcholine receptor subunit alpha-7
      (term hierarchy)
    • InterPro Domains
      IPR038050 Neuronal acetylcholine receptor
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
      IPR002394 Nicotinic acetylcholine receptor
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 1
      cDNA 19
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16565
    References
    more
    • Summaries
      All 348
      Developmental Gene Expression 20
      Diseases 3
      Gene Ontology 40
      Phenotypes 236
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:344622 Guhathakurta D, et al., Hydroxynorketamine, but not ketamine, acts via alpha7 nicotinic acetylcholine receptor to control presynaptic function and gene expression. Transl Psychiatry. 2024 Jan 22;14(1):47
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory