About   Help   FAQ
Fgfr1 Gene Detail
Summary
  • Symbol
    Fgfr1
  • Name
    fibroblast growth factor receptor 1
  • Synonyms
    Eask, Fgfr-1, FGFR-I, Flt-2, Fr1, Hspy
  • Feature Type
    protein coding gene
  • IDs
    MGI:95522
    NCBI Gene: 14182
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:26008808-26067819 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 14.12 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1495 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95522
 protein coding gene Chr8:26003670-26067819 (+)
129S1/SvImJ ENSMUSG00200020805
 protein coding gene Chr8:21063254-21106702 (+)
A/J ENSMUSG00195004759
 protein coding gene Chr8:21605131-21648579 (+)
AKR/J ENSMUSG00220023440
 protein coding gene Chr8:21228705-21272156 (+)
BALB/cJ ENSMUSG00180005274
 protein coding gene Chr8:21129710-21173161 (+)
C3H/HeJ ENSMUSG00175006399
 protein coding gene Chr8:21192480-21235924 (+)
C57BL/6NJ ENSMUSG00215006694
 protein coding gene Chr8:21107381-21150851 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030923
 protein coding gene Chr8:19986550-20049275 (+)
CAST/EiJ ENSTCUG00005021384
 protein coding gene Chr8:21407783-21451782 (+)
CBA/J ENSMUSG00210013726
 protein coding gene Chr8:21129002-21172448 (+)
DBA/2J ENSMUSG00185034032
 protein coding gene Chr8:26929704-26973152 (+)
FVB/NJ ENSMUSG00205003630
 protein coding gene Chr8:20627844-20671294 (+)
JF1/MsJ ENSUMUG00000018963
 protein coding gene Chr8:28803783-28847690 (+)
LP/J ENSMUSG00230014278
 protein coding gene Chr8:30689221-30732666 (+)
NOD/ShiLtJ ENSMUSG00190004000
 protein coding gene Chr8:21162473-21205915 (+)
NZO/HlLtJ ENSMUSG00225020870
 protein coding gene Chr8:34310573-34354016 (+)
PWK/PhJ ENSLUMG00010023526
 protein coding gene Chr8:21177429-21221176 (+)
SPRET/EiJ ENSMSPG00010015569
 protein coding gene Chr8:21443421-21500452 (+)
WSB/EiJ ENSIUOG00005009933
 protein coding gene Chr8:21875510-21918935 (+)



Homology
more
  • Human Ortholog
    FGFR1, fibroblast growth factor receptor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGFR1, fibroblast growth factor receptor 1
  • Synonyms
    BFGFR, bFGF-R-1, CD331, CEK, ECCL, FGFBR, FGFR-1, FLG, FLT-2, FLT2, HBGFR, HH2, HRTFDS, KAL2, N-SAM, OGD
  • Links
    NCBI Gene ID: 2260
    UniProt: P11362

  • Chr Location
    8p11.23; chr8:38400215-38468834 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Fgfr1 mouse models; 15 with human FGFR1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    267 phenotypes from 36 alleles in 39 genetic backgrounds
    81 phenotypes from multigenic genotypes
    5 images
    247 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations die around gastrulation and show defective patterning of axial structures. Hypomorphic and selectively ablated mutations exhibit a wide range of abnormalities affecting diverse structures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    183
  • GO References
    48
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1890
  • Tissues
    707
  • cDNA Data
    242
  • Literature Summary
    319
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14182 NCBI Gene Model | MGI Sequence Detail 59012 C57BL/6J ±  kb
    transcript NM_010206 RefSeq | MGI Sequence Detail 7077 ZRU/MplStud  
    polypeptide P16092 UniProt | EBI | MGI Sequence Detail 822 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 331
      Genomic 12
      cDNA 248
      Primer pair 45
      Other 26
      Antibodies 21

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-9776, MGD-MRK-9781, MGD-MRK-9833, MGI:2142774, MGI:2662561, MGI:3836280
    References
    more
    • Summaries
      All 751
      Developmental Gene Expression 319
      Diseases 5
      Gene Ontology 48
      Phenotypes 247
    • Earliest
      J:29471 Ruta M, et al., Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG). Proc Natl Acad Sci U S A. 1989 Nov;86(22):8722-6
    • Latest
      J:388803 Mathias NA, et al., Loss of the endoplasmic reticulum protein canopy 1 disrupts the function and circuit organization of V2R-expressing vomeronasal sensory neurons. Development. 2026 Jun 15;153(12):dev205386
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory