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Ager Gene Detail
Summary
  • Symbol
    Ager
  • Name
    advanced glycosylation end product-specific receptor
  • Synonyms
    RAGE
  • Feature Type
    protein coding gene
  • IDs
    MGI:893592
    NCBI Gene: 11596
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34816836-34819910 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.18 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_893592
 protein coding gene Chr17:34816545-34819911 (+)
129S1/SvImJ ENSMUSG00200050827
 protein coding gene Chr17:30519999-30523073 (+)
A/J ENSMUSG00195034225
 protein coding gene Chr17:31421130-31424204 (+)
AKR/J ENSMUSG00220037935
 protein coding gene Chr17:30448751-30451825 (+)
BALB/cJ ENSMUSG00180032691
 protein coding gene Chr17:30791183-30794257 (+)
C3H/HeJ ENSMUSG00175027280
 protein coding gene Chr17:30334861-30337935 (+)
C57BL/6NJ ENSMUSG00215046044
 protein coding gene Chr17:30360167-30363241 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021464
 protein coding gene Chr17:31384279-31387396 (+)
CAST/EiJ ENSTCUG00005050476
 protein coding gene Chr17:31379358-31382431 (+)
CBA/J ENSMUSG00210048848
 protein coding gene Chr17:30156971-30160045 (+)
DBA/2J ENSMUSG00185042641
 protein coding gene Chr17:32810460-32813534 (+)
FVB/NJ ENSMUSG00205036154
 protein coding gene Chr17:30678585-30681669 (+)
JF1/MsJ ENSUMUG00000047433
 protein coding gene Chr17:32063053-32066126 (+)
LP/J ENSMUSG00230054495
 protein coding gene Chr17:33918277-33921351 (+)
NOD/ShiLtJ ENSMUSG00190037440
 protein coding gene Chr17:30281152-30284226 (+)
NZO/HlLtJ ENSMUSG00225052298
 protein coding gene Chr17:35931764-35934837 (+)
PWK/PhJ ENSLUMG00010042957
 protein coding gene Chr17:29888781-29891865 (+)
SPRET/EiJ ENSMSPG00010041245
 protein coding gene Chr17:31080490-31083573 (+)
WSB/EiJ ENSIUOG00005048940
 protein coding gene Chr17:31007610-31010694 (+)



Homology
more
  • Human Ortholog
    AGER, advanced glycosylation end-product specific receptor
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGER, advanced glycosylation end-product specific receptor
  • Synonyms
    RAGE, SCARJ1, sRAGE
  • Links
    NCBI Gene ID: 177
    UniProt: Q15109

  • Chr Location
    6p21.32; chr6:32180963-32184344 (-)  GRCh38
Human Diseases
more
  • Diseases
    23 with human AGER associations

Human Disease Mouse Models
      
IDs
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 View 1 model
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 5 alleles in 7 genetic backgrounds
    8 phenotypes from multigenic genotypes
    249 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show increased bone mass and strength, reduced osteoclast number, abnormal blood vessel healing, and altered development of nephropathy and pain perception in induced diabetes. Homozygotes for another null allele show restored diabetes-induced angiogenic responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    195
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    727
  • Tissues
    78
  • cDNA Data
    24
  • Literature Summary
    33
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015452 Ensembl Gene Model | MGI Sequence Detail 3075 C57BL/6J ±  kb
    transcript ENSMUST00000015596 Ensembl | MGI Sequence Detail 1370 Not Applicable  
    polypeptide ENSMUSP00000015596 Ensembl | MGI Sequence Detail 402 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000003828 advanced glycosylation end product-specific receptor
      (term hierarchy)
    • PDB
      4IM8
    • InterPro Domains
      IPR013162 CD80-like, immunoglobulin C2-set
      IPR051116 Cell Surface Receptors and Adhesion Molecules
      IPR003599 Immunoglobulin domain subtype
      IPR013151 Immunoglobulin-like beta-sandwich domain
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
      IPR003598 Immunoglobulin subtype 2
    • GlyGen
      Q62151 2 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 1
      cDNA 24
      Primer pair 3
      Antibodies 5

      Microarray probesets 3
    References
    more
    • Summaries
      All 407
      Developmental Gene Expression 33
      Diseases 1
      Gene Ontology 28
      Phenotypes 249
    • Earliest
      J:55874 Hofmann MA, et al., RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell. 1999 Jun 25;97(7):889-901
    • Latest
      J:384590 Ghosh S, et al., Chemokine-defined macrophage niches establish spatial organization of tumor immunity. Nat Immunol. 2026 Apr;27(4):715-724
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory