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Ager Gene Detail
Summary
  • Symbol
    Ager
  • Name
    advanced glycosylation end product-specific receptor
  • Synonyms
    RAGE
  • Feature Type
    protein coding gene
  • IDs
    MGI:893592
    NCBI Gene: 11596
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34816836-34819910 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.18 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_893592
 protein coding gene Chr17:34816545-34819911 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023579
 protein coding gene Chr17:34672490-34675564 (+)
A/J MGP_AJ_G0023541
 protein coding gene Chr17:33496202-33499276 (+)
AKR/J MGP_AKRJ_G0023506
 protein coding gene Chr17:33912759-33915833 (+)
BALB/cJ MGP_BALBcJ_G0023545
 protein coding gene Chr17:33643620-33646694 (+)
C3H/HeJ MGP_C3HHeJ_G0023305
 protein coding gene Chr17:34307117-34310191 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023985
 protein coding gene Chr17:35992304-35995378 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021464
 protein coding gene Chr17:31384279-31387396 (+)
CAST/EiJ MGP_CASTEiJ_G0022805
 protein coding gene Chr17:34378802-34381875 (+)
CBA/J MGP_CBAJ_G0023283
 protein coding gene Chr17:37526204-37529278 (+)
DBA/2J MGP_DBA2J_G0023411
 protein coding gene Chr17:32786125-32789199 (+)
FVB/NJ MGP_FVBNJ_G0023378
 protein coding gene Chr17:32688853-32691937 (+)
LP/J MGP_LPJ_G0023489
 protein coding gene Chr17:34947630-34950704 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023401
 protein coding gene Chr17:36411194-36414268 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024028
 protein coding gene Chr17:34217937-34221010 (+)
PWK/PhJ MGP_PWKPhJ_G0022553
 protein coding gene Chr17:31714855-31717939 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022370
 protein coding gene Chr17:32207535-32210617 (+)
WSB/EiJ MGP_WSBEiJ_G0022866
 protein coding gene Chr17:34311451-34314535 (+)



Homology
more
  • Human Ortholog
    AGER, advanced glycosylation end-product specific receptor
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGER, advanced glycosylation end-product specific receptor
  • Synonyms
    RAGE, SCARJ1, sRAGE
  • Links
    NCBI Gene ID: 177
    neXtProt AC: NX_Q15109
    UniProt: Q15109

  • Chr Location
    6p21.32; chr6:32180968-32184322 (-)  GRCh38
Human Diseases
more
  • Diseases
    22 with human AGER associations

Human Disease Mouse Models
      
IDs
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 View 1 model
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 5 alleles in 7 genetic backgrounds
    8 phenotypes from multigenic genotypes
    220 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show increased bone mass and strength, reduced osteoclast number, abnormal blood vessel healing, and altered development of nephropathy and pain perception in induced diabetes. Homozygotes for another null allele show restored diabetes-induced angiogenic responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    140
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    792
  • Tissues
    52
  • cDNA Data
    24
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015452 Ensembl Gene Model | MGI Sequence Detail 3075 C57BL/6J ±  kb
    transcript ENSMUST00000015596 Ensembl | MGI Sequence Detail 1370 Not Applicable  
    polypeptide ENSMUSP00000015596 Ensembl | MGI Sequence Detail 402 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 1
      cDNA 24
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 348
      Developmental Gene Expression 24
      Diseases 1
      Gene Ontology 23
      Phenotypes 220
    • Earliest
      J:55874 Hofmann MA, et al., RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell. 1999 Jun 25;97(7):889-901
    • Latest
      J:345982 Seyed Hosseini Fin N, et al., RAGE and its ligand amyloid beta promote retinal ganglion cell loss following ischemia-reperfusion injury. Front Cell Neurosci. 2023;17:1156084
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory