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Pank3 Gene Detail
Summary
  • Symbol
    Pank3
  • Name
    pantothenate kinase 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387464
    NCBI Gene: 211347
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:35660322-35682112 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 21.96 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    36 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2387464
 protein coding gene Chr11:35660311-35682112 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018155
 protein coding gene Chr11:34178713-34200524 (+)
A/J MGP_AJ_G0018128
 protein coding gene Chr11:32895101-32918015 (+)
AKR/J MGP_AKRJ_G0018092
 protein coding gene Chr11:33886533-33908216 (+)
BALB/cJ MGP_BALBcJ_G0018097
 protein coding gene Chr11:33058601-33080562 (+)
C3H/HeJ MGP_C3HHeJ_G0017910
 protein coding gene Chr11:33840891-33864093 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018551
 protein coding gene Chr11:35219835-35241650 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016206
 protein coding gene Chr11:31349539-31371540 (+)
CAST/EiJ MGP_CASTEiJ_G0017474
 protein coding gene Chr11:33830734-33852139 (+)
CBA/J MGP_CBAJ_G0017883
 protein coding gene Chr11:36906268-36927967 (+)
DBA/2J MGP_DBA2J_G0017993
 protein coding gene Chr11:32639991-32661645 (+)
FVB/NJ MGP_FVBNJ_G0017987
 protein coding gene Chr11:32490114-32512295 (+)
LP/J MGP_LPJ_G0018065
 protein coding gene Chr11:34387313-34410148 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018011
 protein coding gene Chr11:37628151-37652580 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018590
 protein coding gene Chr11:33911557-33934922 (+)
PWK/PhJ MGP_PWKPhJ_G0017255
 protein coding gene Chr11:32726565-32748425 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017047
 protein coding gene Chr11:33680144-33701897 (+)
WSB/EiJ MGP_WSBEiJ_G0017523
 protein coding gene Chr11:33683480-33705092 (+)



Homology
more
  • Human Ortholog
    PANK3, pantothenate kinase 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PANK3, pantothenate kinase 3
  • Links
    NCBI Gene ID: 79646
    neXtProt AC: NX_Q9H999
    UniProt: Q9H999

  • Chr Location
    5q34; chr5:168548495-168579368 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele in combination with either a knock-out of Pank1 or Pank2 exhibit complete embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    863
  • Tissues
    137
  • cDNA Data
    207
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 211347 NCBI Gene Model | MGI Sequence Detail 21791 C57BL/6J ±  kb
    transcript NM_145962 RefSeq | MGI Sequence Detail 7365 C57BL/6  
    polypeptide Q8R2W9 UniProt | EBI | MGI Sequence Detail 370 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 209
      cDNA 208
      Primer pair 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 17
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:232556 Bao J, et al., UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts. PLoS Genet. 2016 May;12(5):e1005863
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory