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Ppargc1a Gene Detail
Summary
  • Symbol
    Ppargc1a
  • Name
    peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
  • Synonyms
    A830037N07Rik, Gm11133, Pgc1, Pgc-1alpha, Pgc-1alphaa, Pgco1, PPAR Gamma Coactivator-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342774
    NCBI Gene: 19017
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:51611592-51725068 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 27.02 cM, cytoband C1
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2574 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342774
 protein coding gene Chr5:51611591-52273316 (-)
129S1/SvImJ ENSMUSG00200000948
 protein coding gene Chr5:47158895-47272800 (-)
A/J ENSMUSG00195014617
 protein coding gene Chr5:46521709-46635230 (-)
AKR/J ENSMUSG00220000562
 protein coding gene Chr5:46591384-46704906 (-)
BALB/cJ ENSMUSG00180006428
 protein coding gene Chr5:46282680-46396172 (-)
C3H/HeJ ENSMUSG00175014538
 protein coding gene Chr5:48311721-48425205 (-)
C57BL/6NJ ENSMUSG00215001767
 protein coding gene Chr5:47086036-47199526 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027213
 protein coding gene Chr5:45413480-45520773 (-)
CAST/EiJ ENSTCUG00005003027
 protein coding gene Chr5:46450448-46564517 (-)
CBA/J ENSMUSG00210024186
 protein coding gene Chr5:47272165-47385647 (-)
DBA/2J ENSMUSG00185001157
 protein coding gene Chr5:49150518-49264016 (-)
FVB/NJ ENSMUSG00205002894
 protein coding gene Chr5:46101333-46214860 (-)
JF1/MsJ ENSUMUG00000000542
 protein coding gene Chr5:53716120-53830533 (-)
LP/J ENSMUSG00230009600
 protein coding gene Chr5:53822638-53936519 (-)
NOD/ShiLtJ ENSMUSG00190000403
 protein coding gene Chr5:46216453-46330795 (-)
NZO/HlLtJ ENSMUSG00225028016
 protein coding gene Chr5:58930226-59043807 (-)
PWK/PhJ ENSLUMG00010001468
 protein coding gene Chr5:46387421-46501388 (-)
SPRET/EiJ ENSMSPG00010012530
 protein coding gene Chr5:47862353-47974970 (-)
WSB/EiJ ENSIUOG00005018561
 protein coding gene Chr5:49192865-49306735 (-)



Homology
more
  • Human Ortholog
    PPARGC1A, PPARG coactivator 1 alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPARGC1A, PPARG coactivator 1 alpha
  • Synonyms
    LEM6, PGC1, PGC1A, PGC-1(alpha), PGC-1alpha, PGC-1v, PPARGC1
  • Links
    NCBI Gene ID: 10891
    UniProt: Q9UBK2

  • Chr Location
    4p15.2; chr4:23755041-24472905 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with Ppargc1a mouse models; 8 with human PPARGC1A associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    145 phenotypes from 11 alleles in 20 genetic backgrounds
    30 phenotypes from multigenic genotypes
    3 images
    334 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display partial postnatal lethality, abnormal glucose and insulin homeostasis, resistance to diet induced obesity, increased oxygen consumption, spongiform encephalopathy, hyperactivity, increased startle reflex, and limb grasping.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    123
  • GO References
    39
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1055
  • Tissues
    149
  • cDNA Data
    45
  • Literature Summary
    118
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029167 Ensembl Gene Model | MGI Sequence Detail 113477 C57BL/6J ±  kb
    transcript ENSMUST00000132734 Ensembl | MGI Sequence Detail 6464 Not Applicable  
    polypeptide ENSMUSP00000117040 Ensembl | MGI Sequence Detail 797 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      cDNA 46
      Primer pair 22
      Other 2
      Antibodies 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1203734, MGI:2443650, MGI:3779388
    References
    more
    • Summaries
      All 1041
      Developmental Gene Expression 118
      Diseases 3
      Gene Ontology 39
      Phenotypes 334
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:391499 Kawaida MY, et al., Elevating Circulating L-Kynurenine Promotes Frailty in Aging Mice. J Cachexia Sarcopenia Muscle. 2026 Feb;17(1):e70214
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory