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Pik3r2 Gene Detail
Summary
  • Symbol
    Pik3r2
  • Name
    phosphoinositide-3-kinase regulatory subunit 2
  • Synonyms
    p85beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098772
    NCBI Gene: 18709
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:71220820-71229357 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    47 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098772
protein coding gene Chr8:71220820-71229369 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033726
protein coding gene Chr8:71069123-71079813 (-)
A/J MGP_AJ_G0033709
protein coding gene Chr8:68172830-68181367 (-)
AKR/J MGP_AKRJ_G0033634
protein coding gene Chr8:70129934-70138521 (-)
BALB/cJ MGP_BALBcJ_G0033705
protein coding gene Chr8:68408676-68417306 (-)
C3H/HeJ MGP_C3HHeJ_G0033415
protein coding gene Chr8:70773554-70782177 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034222
protein coding gene Chr8:73748529-73757063 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031166
protein coding gene Chr8:62990622-62999291 (-)
CAST/EiJ MGP_CASTEiJ_G0032740
protein coding gene Chr8:70246909-70255872 (-)
CBA/J MGP_CBAJ_G0033393
protein coding gene Chr8:76413609-76422164 (-)
DBA/2J MGP_DBA2J_G0033547
protein coding gene Chr8:67891605-67900592 (-)
FVB/NJ MGP_FVBNJ_G0033488
protein coding gene Chr8:67029108-67038412 (-)
LP/J MGP_LPJ_G0033634
protein coding gene Chr8:71090166-71099515 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033531
protein coding gene Chr8:79042244-79052351 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034240
protein coding gene Chr8:70306880-70317938 (-)
PWK/PhJ MGP_PWKPhJ_G0032448
protein coding gene Chr8:67188962-67197582 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032284
protein coding gene Chr8:69273548-69282088 (-)
WSB/EiJ MGP_WSBEiJ_G0032855
protein coding gene Chr8:70674201-70682799 (-)



Homology
more
  • Human Ortholog
    PIK3R2, phosphoinositide-3-kinase regulatory subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIK3R2, phosphoinositide-3-kinase regulatory subunit 2
  • Synonyms
    MPPH, MPPH1, p85, P85B, p85beta, p85-BETA
  • Links
    NCBI Gene ID: 5296
    neXtProt AC: NX_O00459
    UniProt: O00459

  • Chr Location
    19p13.11; chr19:18153163-18170532 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human PIK3R2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have lower blood glucose levels both when fed and after fasting. Insulin sensitivity is improved as well. Homozygosity for the p.G367R mutation leads to enlarged brains and brain ventricles.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031834 Ensembl Gene Model | MGI Sequence Detail 8538 C57BL/6J ±  kb
    transcript ENSMUST00000034296 Ensembl | MGI Sequence Detail 3165 Not Applicable  
    polypeptide ENSMUSP00000034296 Ensembl | MGI Sequence Detail 722 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 79
      cDNA 78
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 7
      Gene Ontology 11
      Phenotypes 36
    • Earliest
      J:36742 Pons S, et al., The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase. Mol Cell Biol. 1995 Aug;15(8):4453-65
    • Latest
      J:345099 Wang X, et al., Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development. BMC Genomics. 2024 Feb 3;25(1):139

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory