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F2rl1 Gene Detail
Summary
  • Symbol
    F2rl1
  • Name
    F2R like trypsin receptor 1
  • Synonyms
    coagulation factor II (thrombin) receptor-like 1, Gpcr11, Par2, PAR-2, Protease-activated receptor-2, proteinase-activated receptor-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:101910
    NCBI Gene: 14063
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:95648240-95661735 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 49.53 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    566 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101910
 protein coding gene Chr13:95648226-95661748 (-)
129S1/SvImJ ENSMUSG00200008457
 protein coding gene Chr13:90148213-90161376 (-)
A/J ENSMUSG00195024101
 protein coding gene Chr13:90650046-90663200 (-)
AKR/J ENSMUSG00220013104
 protein coding gene Chr13:89104234-89117390 (-)
BALB/cJ ENSMUSG00180035902
 protein coding gene Chr13:91184930-91198081 (-)
C3H/HeJ ENSMUSG00175014449
 protein coding gene Chr13:91348412-91361568 (-)
C57BL/6NJ ENSMUSG00215024860
 protein coding gene Chr13:91249311-91262812 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018798
 protein coding gene Chr13:89176860-89190802 (-)
CAST/EiJ ENSTCUG00005009085
 protein coding gene Chr13:90449272-90462422 (-)
CBA/J ENSMUSG00210011291
 protein coding gene Chr13:90670089-90683245 (-)
DBA/2J ENSMUSG00185018257
 protein coding gene Chr13:94330836-94343994 (-)
FVB/NJ ENSMUSG00205008209
 protein coding gene Chr13:90132256-90145406 (-)
JF1/MsJ ENSUMUG00000019903
 protein coding gene Chr13:94040945-94054444 (-)
LP/J ENSMUSG00230036906
 protein coding gene Chr13:104348617-104361965 (-)
NOD/ShiLtJ ENSMUSG00190034601
 protein coding gene Chr13:91030137-91043634 (-)
NZO/HlLtJ ENSMUSG00225032663
 protein coding gene Chr13:96862287-96875631 (-)
PWK/PhJ ENSLUMG00010011204
 protein coding gene Chr13:90135243-90148693 (-)
SPRET/EiJ ENSMSPG00010009011
 protein coding gene Chr13:91394029-91405731 (-)
WSB/EiJ ENSIUOG00005030288
 protein coding gene Chr13:90053756-90066929 (-)



Homology
more
  • Human Ortholog
    F2RL1, F2R like trypsin receptor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    F2RL1, F2R like trypsin receptor 1
  • Synonyms
    GPR11, PAR2
  • Links
    NCBI Gene ID: 2150
    UniProt: P55085

  • Chr Location
    5q13.3; chr5:76818933-76835315 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human F2RL1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 6 alleles in 9 genetic backgrounds
    24 phenotypes from multigenic genotypes
    179 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice may exhibit impaired leukocyte rolling and dendritic cell maturation, altered inflammatory response in various models of acute and chronic inflammatory disease, altered susceptibility to injury and to autoimmune disorders, and abnormal hemodynamic responses and pain thresholds.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    133
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    75
  • cDNA Data
    25
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021678 Ensembl Gene Model | MGI Sequence Detail 13496 C57BL/6J ±  kb
    transcript ENSMUST00000022185 Ensembl | MGI Sequence Detail 2741 Not Applicable  
    polypeptide ENSMUSP00000022185 Ensembl | MGI Sequence Detail 399 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 6
      cDNA 25
      Primer pair 4
      Other 1
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-18739
    References
    more
    • Summaries
      All 273
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 14
      Phenotypes 179
    • Earliest
      J:20517 Nystedt S, et al., Molecular cloning of a potential proteinase activated receptor [see comments]. Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9208-12
    • Latest
      J:390172 Meloun A, et al., Atypical pericapillary Ly6G(+)Nur77(+) macrophages initiate type-2 immune responses to allergens in the mouse lung. Nat Commun. 2026 Jan 22;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory