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Lama2 Gene Detail
Summary
  • Symbol
    Lama2
  • Name
    laminin, alpha 2
  • Synonyms
    mer, merosin, nmf417
  • Feature Type
    protein coding gene
  • IDs
    MGI:99912
    NCBI Gene: 16773
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:26857281-27493021 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 14.23 cM, cytoband A4-B1
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    19106 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99912
 protein coding gene Chr10:26856032-27495754 (-)
129S1/SvImJ ENSMUSG00200009052
 protein coding gene Chr10:23675817-24310523 (-)
A/J ENSMUSG00195014081
 protein coding gene Chr10:23978192-24612969 (-)
AKR/J ENSMUSG00220011114
 protein coding gene Chr10:23658540-24294441 (-)
BALB/cJ ENSMUSG00180015698
 protein coding gene Chr10:24106967-24741705 (-)
C3H/HeJ ENSMUSG00175023567
 protein coding gene Chr10:23775126-24409850 (-)
C57BL/6NJ ENSMUSG00215010650
 protein coding gene Chr10:23647745-24289367 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015201
 protein coding gene Chr10:22940665-23546194 (-)
CAST/EiJ ENSTCUG00005013093
 protein coding gene Chr10:23453857-24101579 (-)
CBA/J ENSMUSG00210023154
 protein coding gene Chr10:23762407-24399684 (-)
DBA/2J ENSMUSG00185007075
 protein coding gene Chr10:23934491-24571771 (-)
FVB/NJ ENSMUSG00205009034
 protein coding gene Chr10:23913653-24550766 (-)
JF1/MsJ ENSUMUG00000009652
 protein coding gene Chr10:23722154-24357282 (-)
LP/J ENSMUSG00230011077
 protein coding gene Chr10:25710238-26344907 (-)
NOD/ShiLtJ ENSMUSG00190014592
 protein coding gene Chr10:24065436-24695224 (-)
NZO/HlLtJ ENSMUSG00225029818
 protein coding gene Chr10:29969084-30603794 (-)
PWK/PhJ ENSLUMG00010009820
 protein coding gene Chr10:23600602-24233469 (-)
SPRET/EiJ ENSMSPG00010014434
 protein coding gene Chr10:24397677-25047289 (-)
WSB/EiJ ENSIUOG00005028811
 protein coding gene Chr10:23361523-23999294 (-)



Homology
more
  • Human Ortholog
    LAMA2, laminin subunit alpha 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LAMA2, laminin subunit alpha 2
  • Synonyms
    LAMM, MDC1A
  • Links
    NCBI Gene ID: 3908
    UniProt: P24043

  • Chr Location
    6q22.33; chr6:128883138-129516566 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Lama2 mouse models; 4 with human LAMA2 associations

Human Disease Mouse Models
      
IDs
 View 10 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    8 with disease annotations
  • References
    11 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    87 phenotypes from 8 alleles in 19 genetic backgrounds
    30 phenotypes from multigenic genotypes
    5 images
    187 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted and spontaneous mutations exhibit progressive growth retardation, ataxia, muscle atrophy and degeneration, infertility, and premature lethality. Muscle fiber degeneration is evident as early as the first week of life.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    99
  • cDNA Data
    63
  • Literature Summary
    82
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16773 NCBI Gene Model | MGI Sequence Detail 635741 C57BL/6J ±  kb
    transcript NM_008481 RefSeq | MGI Sequence Detail 9637 C57BL/6  
    polypeptide Q60675 UniProt | EBI | MGI Sequence Detail 3118 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      Genomic 4
      cDNA 63
      Primer pair 7
      Other 3
      Antibodies 11

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16710, MGD-MRK-9246
    References
    more
    • Summaries
      All 347
      Developmental Gene Expression 82
      Diseases 11
      Gene Ontology 26
      Phenotypes 187
    • Earliest
      J:13125 Michelson AM, et al., Dystrophia muscularis: a hereditary primary myopathy in the house mouse. Proc Natl Acad Sci U S A. 1955 Dec 15;41(12):1079-1084
    • Latest
      J:378683 Leblanc E, et al., Identification of skeletal muscle stem cell adhesion motifs using spot-synthesis-based peptide arrays. iScience. 2026 Jan 16;29(1):114498
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory