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Mtf1 Gene Detail
Summary
  • Symbol
    Mtf1
  • Name
    metal response element binding transcription factor 1
  • Synonyms
    metalloregulatory transcription factor, metal response element-binding transcription factor 1, MTF-1, Thyls
  • Feature Type
    protein coding gene
  • IDs
    MGI:101786
    NCBI Gene: 17764
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:124696342-124743593 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 57.91 cM, cytoband D1
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    296 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101786
 protein coding gene Chr4:124695897-124743593 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028754
 protein coding gene Chr4:126355590-126409106 (+)
A/J MGP_AJ_G0028713
 protein coding gene Chr4:121397845-121451153 (+)
AKR/J MGP_AKRJ_G0028666
 protein coding gene Chr4:124715154-124764150 (+)
BALB/cJ MGP_BALBcJ_G0028736
 protein coding gene Chr4:121973818-122024990 (+)
C3H/HeJ MGP_C3HHeJ_G0028450
 protein coding gene Chr4:124811671-124860102 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029178
 protein coding gene Chr4:131221424-131272191 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026451
 protein coding gene Chr4:114573467-114621884 (+)
CAST/EiJ MGP_CASTEiJ_G0027883
 protein coding gene Chr4:122868724-122919885 (+)
CBA/J MGP_CBAJ_G0028416
 protein coding gene Chr4:134477874-134527566 (+)
DBA/2J MGP_DBA2J_G0028565
 protein coding gene Chr4:121875743-121922617 (+)
FVB/NJ MGP_FVBNJ_G0028532
 protein coding gene Chr4:120501548-120548714 (+)
LP/J MGP_LPJ_G0028666
 protein coding gene Chr4:126654954-126703129 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028558
 protein coding gene Chr4:139475841-139525635 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029216
 protein coding gene Chr4:125084822-125132976 (+)
PWK/PhJ MGP_PWKPhJ_G0027604
 protein coding gene Chr4:118294217-118343978 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027430
 protein coding gene Chr4:120856423-120904852 (+)
WSB/EiJ MGP_WSBEiJ_G0027963
 protein coding gene Chr4:125158181-125206649 (+)



Homology
more
  • Human Ortholog
    MTF1, metal regulatory transcription factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTF1, metal regulatory transcription factor 1
  • Synonyms
    MTF-1, ZRF
  • Links
    NCBI Gene ID: 4520
    neXtProt AC: NX_Q14872
    UniProt: Q14872

  • Chr Location
    1p34.3; chr1:37809574-37859592 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 6 alleles in 6 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation show impaired hepatocyte development followed by embryonic liver degeneration, generalized edema, and death at ~14 days of gestation. Mutant embryonic fibroblasts show increased susceptibility to the cytotoxiceffects of cadmium and hydrogen peroxide.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    807
  • Tissues
    92
  • cDNA Data
    14
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17764 NCBI Gene Model | MGI Sequence Detail 47252 C57BL/6J ±  kb
    transcript NM_008636 RefSeq | MGI Sequence Detail 7631 ZRU/MplStud  
    polypeptide Q07243 UniProt | EBI | MGI Sequence Detail 675 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 1
      cDNA 15
      Primer pair 1
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-18594, MGI:2151619
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 9
      Gene Ontology 10
      Phenotypes 29
    • Earliest
      J:4714 Radtke F, et al., Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter. EMBO J. 1993 Apr;12(4):1355-62
    • Latest
      J:333098 Chee JM, et al., Genome-wide screening reveals the genetic basis of mammalian embryonic eye development. BMC Biol. 2023 Feb 3;21(1):22
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory