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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Syk
spleen tyrosine kinase
MGI:99515
41 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Itgamtm1Myd/Itgamtm1Myd
Syktm1Tyb/Syktm1.2Tara
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6 		impaired granulocyte bactericidal activity J:155479
Syktm1.1(cre)Fkfr/Syktm1.1(cre)Fkfr
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sortm1(EYFP)Cos
involves: 129S1/Sv * 129X1/SvJ 		abnormal blood vessel morphology J:159112
abnormal liver development J:159112
abnormal lymphangiogenesis J:159112
decreased leukocyte cell number J:159112
decreased liver weight J:159112
increased leukocyte cell number J:159112
liver hypoplasia J:159112
Syktm1Kuro/Syktm1Kuro
Zap70tm1Dlo/Zap70tm1Dlo
Cd79atm1(cre)Reth/?
involves: 129P2/OlaHsd * BALB/c * C57BL/6 		abnormal pro-B cell differentiation J:134528
Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
B6.129-Syktm2.1(ZAP70)Fkfr 		abnormal B cell physiology J:188422
abnormal neutrophil physiology J:188422
abnormal renal glomerular capsule morphology J:188422
abnormal renal glomerulus basement membrane morphology J:188422
arrested B cell differentiation J:188422
decreased B cell number J:188422
decreased blood urea nitrogen level J:188422
decreased bone marrow cell number J:188422
decreased circulating creatinine level J:188422
decreased DN1 thymic pro-T cell number J:188422
decreased IgG1 level J:188422
decreased IgG2a level J:188422
decreased IgG2b level J:188422
decreased marginal zone B cell number J:188422
decreased mature B cell number J:188422
decreased transitional stage B cell number J:188422
decreased transitional stage T1 B cell number J:188422
decreased transitional stage T2 B cell number J:188422
expanded mesangial matrix J:188422
glomerulonephritis J:188422
normal immune system phenotype J:188422
increased anti-insulin autoantibody level J:188422
increased B cell apoptosis J:188422
increased CD4-positive, alpha-beta memory T cell number J:188422
increased CD4-positive, alpha-beta T cell number J:188422
increased CD8-positive, alpha-beta memory T cell number J:188422
increased CD8-positive, alpha-beta T cell number J:188422
increased circulating glucose level J:188422
increased DN3 thymocyte number J:188422
increased IgM level J:188422
increased mesangial cell number J:188422
increased urine protein level J:188422
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory