Wnt5a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Wnt5a
wingless-type MMTV integration site family, member 5A
MGI:98958

92 phenotypes from 5 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sor^{tm1(CAG-Wnt5a,-AcGFP)Skde}/Gt(ROSA)26Sor⁺ Pgr^tm2(cre)Lyd/Pgr⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal embryo attachment	J:233595
	abnormal embryo development	J:233595
	abnormal maternal decidual layer morphology	J:233595
	abnormal placenta morphology	J:233595
	abnormal trophoblast giant cell proliferation	J:233595
	abnormal uterine-embryonic axis	J:233595
	abnormal uterus morphology	J:233595
	decreased litter size	J:233595
	decreased placental labyrinth size	J:233595
	impaired embryo implantation	J:233595
	impaired spacing of implantation sites	J:233595
	reduced female fertility	J:233595
	normal reproductive system phenotype	J:233595
	twin decidual capsule	J:233595
Pgr^tm2(cre)Lyd/Pgr⁺ Wnt5a^tm1.1Tpy/Wnt5a^tm1.1Tpy involves: 129S1/Sv * 129X1/SvJ	abnormal embryo attachment	J:233595
	abnormal embryo development	J:233595
	abnormal maternal decidual layer morphology	J:233595
	abnormal placenta morphology	J:233595
	abnormal trophoblast giant cell proliferation	J:233595
	abnormal uterine-embryonic axis	J:233595
	abnormal uterus morphology	J:233595
	decreased litter size	J:233595
	decreased placental labyrinth size	J:233595
	impaired embryo implantation	J:233595
	impaired spacing of implantation sites	J:233595
	reduced female fertility	J:233595
	normal reproductive system phenotype	J:233595
	twin decidual capsule	J:233595
Wnt5a^b2b3077.1Clo/Wnt5a^b2b3077.1Clo C57BL/6J-Wnt5a^b2b3077.1Clo	abnormal autopod morphology	J:175213
	abnormal intestine morphology	J:175213
	abnormal kidney morphology	J:175213
	abnormal limb morphology	J:175213
	abnormal tail morphology	J:175213
	abnormal thoracic cavity morphology	J:175213
	atrioventricular septal defect	J:175213
	cleft palate	J:175213
	cleft upper lip	J:175213
	double outlet right ventricle	J:175213
	heart left ventricle hypoplasia	J:175213
	micrognathia	J:175213
	persistent truncus arteriosus	J:175213
	pulmonary artery hypoplasia	J:175213
	pulmonary hypoplasia	J:175213
	short snout	J:175213
	syndactyly	J:175213
	thymus hypoplasia	J:175213
Wnt5a^tm1.1Krvl/Wnt5a^tm1.1Krvl involves: 129S6/SvEvTac * C57BL/6	no abnormal phenotype detected	J:196291
Wnt5a^tm1.1Krvl/Wnt5a^tm1.1Krvl Tg(Th-cre)#Gsat/0 involves: 129S6/SvEvTac * C57BL/6 * FVB/N	abnormal superior cervical ganglion morphology	J:196291
	abnormal sympathetic neuron innervation pattern	J:196291
	decreased neuron number	J:196291
Wnt5a^tm1.1Tpy/Wnt5a^tm1.1Tpy Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 involves: 129S/SvEv * 129S1/Sv * C57BL/6	abnormal intestine regeneration	J:187747
	abnormal wound healing	J:187747
Wnt5a^tm1.1Tpy/Wnt5a^tm1.1Tpy Tg(CAG-cre/Esr1)5Amc/0 involves: 129S1/Sv C57BL/6 * CBA	abnormal intestine regeneration	J:187747
	abnormal wound healing	J:187747
Wnt5a^tm1Amc/Wnt5a^tm1.1Krvl H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * CBA/J	abnormal axon extension	J:196291
	abnormal craniofacial morphology	J:196291
	abnormal sympathetic neuron innervation pattern	J:196291
	increased neuron apoptosis	J:196291
	neonatal lethality, complete penetrance	J:196291
Wnt5a^tm1Amc/Wnt5a^tm1Amc involves: 129S7/SvEvBrd	abnormal anus morphology	J:153152
	abnormal colon morphology	J:153152
	abnormal liver morphology	J:153152
	abnormal primordial germ cell migration	J:179805
	abnormal rectum morphology	J:153152
	abnormal urinary bladder morphology	J:153152
	absent anus	J:153152
	absent rectum	J:153152
	anal atresia	J:153152
	decreased autopod size	J:184918
	decreased body size	J:153152
	decreased colon length	J:153152
	decreased primordial germ cell number	J:179805
	enlarged liver	J:153152
	genital tubercle hypoplasia	J:153152
	increased primordial germ cell apoptosis	J:179805
	normal nervous system phenotype	J:155074
	short limbs	J:153152, J:184918
	short tail	J:153152
Wnt5a^tm1Amc/Wnt5a^tm1Amc involves: 129S7/SvEvBrd * C57BL/6	abnormal digestive system development	J:204986
	abnormal embryonic tissue morphology	J:52600
	abnormal lung development	J:78384
	abnormal lung interstitium morphology	J:78384
	abnormal mesenchyme morphology	J:204986
	abnormal midgut morphology	J:204986
	abnormal presomitic mesoderm morphology	J:52600
	abnormal primitive streak formation	J:52600
	abnormal reproductive system morphology	J:52600
	abnormal vertebrae morphology	J:52600
	absent caudal vertebrae	J:52600
	absent external female genitalia	J:52600
	absent external male genitalia	J:52600
	adactyly	J:52600
	decreased body length	J:52600
	decreased somite size	J:52600
	decreased tongue size	J:52600
	decreased tracheal cartilage ring number	J:78384
	delayed bone ossification	J:52600
	neonatal lethality, complete penetrance	J:52600, J:78384
	respiratory failure	J:78384
	rib fusion	J:52600
	short humerus	J:52600
	short limbs	J:52600
	short mandible	J:52600
	short radius	J:52600
	short snout	J:52600
	short trachea	J:78384
	short ulna	J:52600
	short vertebral column	J:78384
	small ears	J:52600
	small vertebrae	J:52600
	vertebral fusion	J:52600
	vestigial tail	J:52600

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23