Wnt5a^tm1.1Tpy
Targeted Allele Detail

Summary

• Symbol: Wnt5a^tm1.1Tpy
• Name: wingless-type MMTV integration site family, member 5A; targeted mutation 1.1, Terry P Yamaguchi
• MGI ID: MGI:5440733
• Synonyms: Wnt5a^flox
• Gene: Wnt5a Location: Chr14:28226707-28249405 bp, + strand Genetic Position: Chr14, 16.8 cM
• Alliance: Wnt5a^tm1.1Tpy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187747
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP and FRT flanked inverted neo cassette was inserted upstream of exon 2 and a loxP site was inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:187747)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnt5a Mutation: 40 strains or lines available

References

• Original: J:187747 Miyoshi H, et al., Wnt5a potentiates TGF-beta signaling to promote colonic crypt regeneration after tissue injury. Science. 2012 Oct 5;338(6103):108-13
• All: 18 reference(s)