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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Vav1
vav 1 oncogene
MGI:98923
50 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cblbtm1Pngr/Cblbtm1Pngr
Vav1tm1Tyb/Vav1tm1Tyb
Wastm1Sbs/Wastm1Sbs
involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac 		abnormal T cell physiology J:79550
Itktm1Litt/Itktm1Litt
Vav1tm2Bbd/Vav1tm2Bbd
B6.129-Itktm1Litt Vav1tm2Bbd 		abnormal CD4-positive T cell differentiation J:141390
abnormal CD8-positive, alpha-beta T cell differentiation J:141390
abnormal positive T cell selection J:141390
abnormal T cell morphology J:141390
abnormal T cell physiology J:141390
decreased CD4-positive, alpha-beta T cell number J:141390
decreased CD8-positive, alpha-beta T cell number J:141390
decreased double-positive T cell number J:141390
decreased T cell number J:141390
decreased thymocyte number J:141390
increased B cell number J:141390
increased T cell apoptosis J:141390
Rag1tm1Bal/Rag1tm1Bal
Vav1tm2Tyb/Vav1tm2Tyb
involves: 129S4/SvJae * 129S8/SvEv 		arrested T cell differentiation J:113270
Rag1tm1Bal/Rag1tm1Bal
Vav1tm2Tyb/Vav1tm2Tyb
Tg(TcrAND)53Hed/0
involves: 129S4/SvJae * 129S8/SvEv * C57BL/6 * SJL 		decreased CD4-positive, alpha-beta T cell number J:113270
Rasgrf2tm1Esn/Rasgrf2tm1Esn
Vav1tm1Tyb/Vav1tm1Tyb
involves: 129S1/Sv * 129S2/SvPas * C57BL/10 * C57BR/cd 		abnormal T cell physiology J:128985
decreased interleukin-2 secretion J:128985
decreased T cell proliferation J:128985
decreased tumor necrosis factor secretion J:128985
Vav1tm1Tyb/Vav1tm1Tyb
Vav2tm1Kdf/Vav2tm1Kdf
involves: 129S1/Sv * 129S2/SvPas 		decreased B cell proliferation J:86654
decreased double-negative T cell number J:86654
decreased double-positive T cell number J:86654
decreased interferon-gamma secretion J:86654
decreased interleukin-2 secretion J:86654
decreased mature B cell number J:86654
decreased single-positive T cell number J:86654
decreased T cell number J:86654
decreased T cell proliferation J:86654
decreased thymocyte number J:86654
Vav1tm1Tyb/Vav1tm1Tyb
Vav2tm1Kdf/Vav2tm1Kdf
Vav3tm1Swat/Vav3tm1Swat
involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac 		abnormal macrophage physiology J:145345
abnormal neutrophil physiology J:145345
abnormal NK cell physiology J:187430
decreased interleukin-10 secretion J:145345
decreased tumor necrosis factor secretion J:145345
Vav1tm1Tyb/Vav1tm1Tyb
Vav2tm1Kdf/Vav2tm1Kdf
Vav3tm1Swat/Vav3tm1Swat
involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * C57BL/6 		abnormal B cell physiology J:86654
abnormal enterocyte morphology J:146174
abnormal humoral immune response J:86654
abnormal T cell physiology J:86654
arrested B cell differentiation J:86654
arrested T cell differentiation J:86654
decreased B cell proliferation J:86654
decreased double-positive T cell number J:86654
decreased follicular B cell number J:86654
decreased IgG1 level J:86654
decreased IgG2b level J:86654
decreased IgG3 level J:86654
decreased IgM level J:86654
decreased immunoglobulin level J:86654
decreased interferon-gamma secretion J:86654
decreased interleukin-2 secretion J:86654
decreased marginal zone B cell number J:86654
decreased mature B cell number J:86654
decreased single-positive T cell number J:86654
decreased T cell number J:86654
decreased T cell proliferation J:86654
decreased thymocyte number J:86654
decreased transitional stage T2 B cell number J:86654
impaired wound healing J:146174
increased immature B cell number J:86654
increased transitional stage T1 B cell number J:86654
intestinal ulcer J:146174
Vav1tm1Tyb/Vav1tm1Tyb
Vav2tm1Tnr/Vav2tm1Tnr
involves: 129P2/OlaHsd * 129S2/SvPas 		abnormal B cell physiology J:69807
decreased B cell number J:69807
decreased B cell proliferation J:69807
decreased CD4-positive, alpha-beta T cell number J:69807
decreased CD8-positive, alpha-beta T cell number J:69807
decreased follicular B cell number J:69807
decreased immature B cell number J:69807
decreased mature B cell number J:69807
Vav1tm1Tyb/Vav1tm1Tyb
Vav3tm1Swat/Vav3tm1Swat
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 		decreased B cell proliferation J:86654
decreased double-negative T cell number J:86654
decreased double-positive T cell number J:86654
decreased interferon-gamma secretion J:86654
decreased interleukin-2 secretion J:86654
decreased mature B cell number J:86654
decreased single-positive T cell number J:86654
decreased T cell number J:86654
decreased T cell proliferation J:86654
Vav1tm2Bbd/Vav1tm2Bbd
Vav2tm1Kdf/Vav2tm1Kdf
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal B cell activation J:69806
abnormal B cell differentiation J:69806
abnormal lymph node cell ratio J:69806
abnormal splenic cell ratio J:69806
abnormal T cell differentiation J:69806
decreased B cell number J:69806
decreased B cell proliferation J:69806
decreased B-1 B cell number J:69806
decreased CD8-positive, alpha-beta T cell number J:69806
decreased IgG1 level J:69806
decreased IgG2b level J:69806
decreased IgG3 level J:69806
decreased IgM level J:69806
decreased immunoglobulin level J:69806
decreased mature B cell number J:69806
decreased T cell number J:69806
thymus hypoplasia J:69806
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory