Vav2^tm1Tnr
Targeted Allele Detail

Summary

• Symbol: Vav2^tm1Tnr
• Name: vav 2 oncogene; targeted mutation 1, Martin Turner
• MGI ID: MGI:2387845
• Synonyms: Vav2^-, Vav2^tmTrn
• Gene: Vav2 Location: Chr2:27152116-27317045 bp, - strand Genetic Position: Chr2, 19.36 cM
• Alliance: Vav2^tm1Tnr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69807
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into exon 8 which encodes an essential part of the Dbl domain. Western blot analysis of splenic lymphocytes from homozygous mutant animals did not detect protein product. (J:69807)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vav2 Mutation: 45 strains or lines available

References

• Original: J:69807 Doody GM, et al., Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation. Nat Immunol. 2001 Jun;2(6):542-7
• All: 40 reference(s)