Analysis Tools
homeostasis/metabolism
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• mice exhibit an increase in serum vasopressin levels compared with wild-type mice
• however, treatment with propranolol restores normal levels
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• mice exhibit an increase in serum noradrenaline levels compared with wild-type mice
• however, treatment with captopril and propranolol restores normal levels
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• mice exhibit reduced bradykinin serum concentration compared with wild-type mice
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• treatment with captopril prevents alterations in angiotensin II, bradykinin, and noradrenaline levels, up-regulation catecholamines, cardiovascular remodeling, and tissue fibrosis
• treatment with losartan reduces blood pressure to levels similar to in wild-type mice
• treatment with propranolol blocks hypertension, tachycardia, cardiovascular remodeling, restores vasopressin, angiotensin II, and aldosterone plasma levels, and heart and renal fibrosis
• however, bosentan exhibits no effect on mice
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cardiovascular system
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• mice exhibit a severe thickening of the aorta media wall due to increased numbers of smooth muscle cells and high levels of deposition of extracellular matrix
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• mice exhibit a severe thickening of the aorta media wall due to increased numbers of smooth muscle cells and high levels of deposition of extracellular matrix unlike in wild-type mice
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• mice exhibit cardiac defects beginning at 4 months that become more accentuated in older mice unlike in wild-type mice
• however, treatment with captopril or propranolol prevents cardiac remodeling
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• cardiomyocyte hypertrophy
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• mice exhibit cardiac fibrosis in the left ventricle unlike in wild-type mice
• however, treatment with captopril or propranolol prevents fibrosis
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• whether anesthetized or awake
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hypertension
(
J:124056
)
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• whether anesthetized or awake, mice exhibit hypertension compared with wild-type mice
• however, treatment with losartan or propranolol blocks hypertension
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immune system
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• in response to BCR stimulation
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• the number of IgMloIgDhi B cells is reduced in the lymph nodes compared to in wild-type mice
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• reduced 80%
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• in response to primary immunization or re-immunization with DNP-KLH
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• in response to primary immunization or re-immunization with DNP-KLH
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• mice produce less than normal IgG3 in response to immunization with DNP-ficoll or DNP-KLH
• however, IgG3 production in response to immunization with DNP-KLH is normal
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• mice produce less than normal IgM in response to immunization with DNP-ficoll
• however, IgM production in response to immunization with DNP-KLH is normal
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renal/urinary system
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• mice exhibit renal fibrosis in the left ventricle unlike in wild-type mice
• however, treatment with captopril or propranolol prevents fibrosis
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endocrine/exocrine glands
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• medulla cells are hyper-activated and contain fewer catecholamine-containing vesicles compared with wild-type cells
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muscle
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• mice exhibit a severe thickening of the aorta media wall due to increased numbers of smooth muscle cells and high levels of deposition of extracellular matrix unlike in wild-type mice
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• cardiomyocyte hypertrophy
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nervous system
hydrocephaly
(
J:124056
)
hematopoietic system
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• in response to BCR stimulation
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• the number of IgMloIgDhi B cells is reduced in the lymph nodes compared to in wild-type mice
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• reduced 80%
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• in response to primary immunization or re-immunization with DNP-KLH
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• in response to primary immunization or re-immunization with DNP-KLH
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• mice produce less than normal IgG3 in response to immunization with DNP-ficoll or DNP-KLH
• however, IgG3 production in response to immunization with DNP-KLH is normal
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• mice produce less than normal IgM in response to immunization with DNP-ficoll
• however, IgM production in response to immunization with DNP-KLH is normal
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growth/size/body
cellular
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• in response to BCR stimulation
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